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公开(公告)号：US20240269133A1
公开(公告)日：2024-08-15
申请号：US18561405
申请日：2022-05-20
申请人： Purdue Pharma L.P.
发明人： Garth WHITESIDE , Stephen HARRIS
IPC分类号： A61K31/498 , A61K31/137 , A61K31/216 , A61K31/4025 , A61K31/46 , A61K31/4725 , A61P13/10
CPC分类号： A61K31/498 , A61K31/137 , A61K31/216 , A61K31/4025 , A61K31/46 , A61K31/4725 , A61P13/10
摘要： The disclosure provides a method of treating interstitial cystitis/bladder pain syndrome in a human subject in need of such treatment, comprising administering to the human subject a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof. In certain embodiments, the method comprises administering the compound of formula (IA).
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公开(公告)号：US20240058333A1
公开(公告)日：2024-02-22
申请号：US18343182
申请日：2023-06-28
申请人： Purdue Pharma L.P.
IPC分类号： A61K31/498 , A61P25/20
CPC分类号： A61K31/498 , A61P25/20 , A61M21/00
摘要： The disclosure relates to methods for treating or preventing a sleep disorder by administering a compound of Formula (1)(1), or a compound of formula (1A), (1B), (1C), (1D), (1E), or (1F) to an animal in need of such treatment. In certain embodiments, such compounds effectively treat or prevent a sleep disorder in the animal, while producing reduced side effects compared to previously available compounds.
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公开(公告)号：US20190282836A1
公开(公告)日：2019-09-19
申请号：US16318686
申请日：2017-07-25
申请人： Purdue Pharma L.P.
IPC分类号： A61P25/20 , A61K31/498
摘要： The disclosure relates to methods for treating or preventing a sleep disorder by administering a compound of formula (1)(1), or a compound of formula (1A), (1B), (1C), (1D), (1E), or (1F) to an animal in need of such treatment. In certain embodiments, such compounds effectively treat or prevent a sleep disorder in the animal, while producing reduced side effects compared to previously available compounds.
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公开(公告)号：US20220280527A1
公开(公告)日：2022-09-08
申请号：US17569002
申请日：2022-01-05
申请人： Purdue Pharma L.P.
IPC分类号： A61K31/5386 , A61K31/402 , A61K31/421 , A61K31/4439 , A61K31/5377 , A61K9/00 , A61K31/4164 , A61K31/44 , A61K31/485 , A61P25/02 , A61K31/4174 , A61K31/455
摘要： This application relates to using trace amine associated receptor 1 (TAARI) agonists and/or partial agonists for treating or preventing pain, especially neuropathic pain.
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公开(公告)号：US20200215052A1
公开(公告)日：2020-07-09
申请号：US16625011
申请日：2018-06-29
申请人： PURDUE PHARMA L.P.
发明人： Alessandra CIPRIANO , Salvatore COLUCCI , Stephen HARRIS , Michelle HUMMEL , Donald KYLE , Garth WHITESIDE
IPC分类号： A61K31/485 , A61K31/4468 , A61K9/00
摘要： The invention provides an oral dosage form comprising (i) an amount of oxycodone and (ii) an amount of buprenorphine, wherein the weight ratio of the amount of buprenorphine to the amount of oxycodone is greater than 1:40 calculated with the amount of buprenorphine in the dosage form expressed as the equimolar amount of buprenorphine base (Mw=467.64 g/mol) in mg, and the amount of oxycodone in the dosage form expressed as the equimolar amount of oxycodone hydrochloride (Mw=351.82 g/mol) in mg. The invention also provides combinations of an opioid agonist and buprenorphine for use to treat pain, wherein the combination achieves a reduction of adverse pharmacodynamic responses (such as, respiratory depression), compared with a corresponding stand-alone opioid therapy. The invention also includes methods of treatment and dosage forms thereof comprising such combinations.
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公开(公告)号：US20230293516A1
公开(公告)日：2023-09-21
申请号：US18152399
申请日：2023-01-10
申请人： Purdue Pharma L.P.
IPC分类号： A61K31/498 , A61P25/20 , A61P25/32 , A61K9/00 , A61K31/138 , A61K31/145 , A61K31/16 , A61K31/197 , A61K31/485 , A61K31/554 , A61K31/7048
CPC分类号： A61K31/498 , A61P25/20 , A61P25/32 , A61K9/0053 , A61K9/0056 , A61K9/006 , A61K31/138 , A61K31/145 , A61K31/16 , A61K31/197 , A61K31/485 , A61K31/554 , A61K31/7048
摘要： The disclosure relates to methods for treating or preventing an Insomnia Disorder by administering to a human in need thereof a compound of formula (I), or a compound of formula (IA), (IB), or (IC), or a solvate thereof, in a daily dose of from about 0.5 mg to about 6.0 mg. In certain embodiments, such compounds effectively treat or prevent an Insomnia Disorder in the animal, while producing reduced side effects compared to previously available compounds.
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公开(公告)号：US20210330994A1
公开(公告)日：2021-10-28
申请号：US17195434
申请日：2021-03-08
申请人： Purdue Pharma L.P.
IPC分类号： A61P25/20 , A61K31/498
摘要： The disclosure relates to methods for treating or preventing a sleep disorder by administering a compound of formula (1)(1), or a compound of formula (1A), (1B), (1C), (1D), (1E), or (1F) to an animal in need of such treatment. In certain embodiments, such compounds effectively treat or prevent a sleep disorder in the animal, while producing reduced side effects compared to previously available compounds.
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公开(公告)号：US20200345726A1
公开(公告)日：2020-11-05
申请号：US16964174
申请日：2019-01-22
申请人： Purdue Pharma L.P.
IPC分类号： A61K31/498 , A61K9/00 , A61K31/145 , A61K31/485 , A61K31/16 , A61K31/197 , A61K31/7048 , A61K31/138 , A61K31/554 , A61P25/32 , A61P25/20
摘要： The disclosure relates to methods for treating or preventing an Insomnia Disorder by administering to a human in need thereof a compound of formula (I), or a compound of formula (IA), (IB), or (IC), or a solvate thereof, in a daily dose of from about 0.5 mg to about 6.0 mg. In certain embodiments, such compounds effectively treat or prevent an Insomnia Disorder in the animal, while producing reduced side effects compared to previously available compounds.
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公开(公告)号：US20190201410A1
公开(公告)日：2019-07-04
申请号：US16306305
申请日：2017-06-02
申请人： Purdue Pharma L.P.
IPC分类号： A61K31/5386 , A61K31/421 , A61K31/455 , A61K31/4174 , A61K31/402 , A61K31/4439 , A61K31/5377 , A61P25/02
CPC分类号： A61K31/5386 , A61K9/0019 , A61K9/0053 , A61K31/402 , A61K31/4164 , A61K31/4174 , A61K31/421 , A61K31/44 , A61K31/4439 , A61K31/455 , A61K31/485 , A61K31/5377 , A61P25/02
摘要： This application relates to using trace amine associated receptor 1 (TAAR1) agonists and/or partial agonists for treating or preventing pain, especially neuropathic pain.
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