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    Morphinan derivatives and use thereof
    1.
    发明授权
    Morphinan derivatives and use thereof 有权

    公开(公告)号：US10745402B2

    公开(公告)日：2020-08-18

    申请号：US16475251

    申请日：2017-12-20

    Applicant: PURDUE PHARMA L.P.

    Inventor： Laykea Tafesse

    IPC: C07D471/08 ,  A61P25/04

    Abstract: The application is directed to compounds of formula (I): and pharmaceutically acceptable salts, radiolabeled isomers, solvates, or hydrates thereof, wherein R1, R2, R3, X, and n are defined as set forth in the specification. The application is also directed to compounds of formulae II, I-a, I-a1, I-a2, I-b, and I-b1 and the pharmaceutically acceptable salts, radiolabeled isomers, solvates, and hydrates thereof. The application is also directed to use of Compounds of the present disclosure to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. Certain Compounds of the present disclosure are especially useful for treating pain. In one embodiment, Compounds of the present disclosure exhibit less opioid-induced side effects (such as, euphoria or drug-liking).

    HETEROCYCLIC MORPHINAN DERIVATIVES AND USE THEREOF
    5.
    发明申请
    HETEROCYCLIC MORPHINAN DERIVATIVES AND USE THEREOF 审中-公开

    公开(公告)号：US20180111934A1

    公开(公告)日：2018-04-26

    申请号：US15318277

    申请日：2015-06-12

    Applicant: Purdue Pharma L.P.

    Inventor： Laykea Tafesse ,  Mark A. Youngman

    IPC: C07D471/08 ,  A61P25/04

    CPC classification number: C07D471/08 ,  A61P25/04 ,  C07B2200/05

    Abstract: The application is directed to compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, and Z are defined as set forth in the specification. In certain embodiments, the invention is also directed to compounds of Formula II-VII and the pharmaceutically acceptable salts and solvates thereof. The invention is also directed to use of compounds of Formula I to VII, and the pharmaceutically acceptable salts and solvates thereof, to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. Certain compounds of the invention are especially useful for treating pain.

    DIBENZAZEPINE DERIVATIVES AND USE THEREOF
    6.
    发明申请
    DIBENZAZEPINE DERIVATIVES AND USE THEREOF 审中-公开

    公开(公告)号：US20170283392A1

    公开(公告)日：2017-10-05

    申请号：US15623120

    申请日：2017-06-14

    Applicant: Purdue Pharma L.P.

    Inventor： Stephen M. Lynch ,  Laykea Tafesse

    IPC: C07D401/04

    CPC classification number: C07D401/04

    Abstract: The present disclosure provides dibenzazepine derivatives having Formula I or I(A): and the pharmaceutically acceptable salts and solvates thereof, wherein R3a, R3b, R6, V1, V2, Z1, Z2, Z3, and G are defined as set forth in the specification. The present disclosure is also directed to the use of the compounds of Formula I or I(A), and the pharmaceutically acceptable salts or solvates thereof, to treat a disorder responsive to the blockade of one or more sodium channels. In one embodiment, the compounds of the present disclosure are useful for treating pain.

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