公开(公告)号：US20100204169A1

公开(公告)日：2010-08-12

申请号：US12714598

申请日：2010-03-01

申请人： Pui-Kwong CHAN ,  May Sung MAK ,  Yun WANG

发明人： Pui-Kwong CHAN ,  May Sung MAK ,  Yun WANG

IPC分类号： A61K31/70 ,  C07H15/24 ,  A61P35/04

CPC分类号： A23L1/3002 ,  A23L33/105 ,  A23L33/11 ,  A23V2002/00 ,  A61K36/00 ,  A61K36/77 ,  C07H15/256 ,  C07J63/00 ,  A61K2300/00 ,  A23V2200/30 ,  A23V2200/308 ,  A23V2250/2116

摘要： This invention provides compositions, methods and process of producing extracts and pure compounds from Xanthoceras sorbifolia. The extract comprises saponins and other constituents including alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, tannins, acid, flavonoids and others. The composition can be used for treating cancer and other conditions, such as arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, kidney disorder, and impotence; for improving cerebral functions; or for curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease, autism, brain trauma, Parkinson's, cerebral dysfunctions, and treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, headache, dizziness, kidney disorder. This invention provides compounds of oleanene triterpenoidal saponin in nature with the characteristics that at least one angeloyl group attache to Carbon 21 or/and 22, or/and linked to the sugar. The compounds of the present invention have various pharmaceutical and therapeutic applications.

摘要翻译： 本发明提供了从Xanthoceras sorbifolia生产提取物和纯化合物的组合物，方法和方法。 提取物包括皂苷和其他成分，包括生物碱，香豆素，糖类，蛋白质，多糖，糖苷，单宁，酸，类黄酮等。 该组合物可用于治疗关节炎，风湿病，循环不良，动脉硬化，雷诺综合征，心绞痛，心脏病，冠心病，头痛，肾脏疾病和阳treating等癌症和其他病症。 改善脑功能; 或用于治疗遗尿，频繁排尿，尿失禁，痴呆，弱智能和阿尔茨海默病，自闭症，脑外伤，帕金森病，脑功能障碍和治疗关节炎，风湿病，循环不良，动脉硬化，雷诺综合征，心绞痛，心脏病，头痛 ，头晕，肾脏疾病。 本发明提供了本质上的油酸三萜皂苷的化合物，其特征在于至少一个异酰基与碳21或/和22连接或/并连接至糖。 本发明的化合物具有各种药物和治疗应用。

公开(公告)号：US20050220910A1

公开(公告)日：2005-10-06

申请号：US10906303

申请日：2005-02-14

申请人： Pui-Kwong CHAN ,  May Sung MAK ,  Yun WANG

发明人： Pui-Kwong CHAN ,  May Sung MAK ,  Yun WANG

IPC分类号： A61K31/704 ,  A61K35/78

CPC分类号： A61K31/704 ,  A61K36/77 ,  C07H15/256 ,  C07J63/00

摘要： This invention provides compositions, methods and process of producing extracts from Xanthoceras sorbifolia. The extract comprises alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, saponins, tannins, acid, flavonoids and others. The composition can be used for treating cancer, arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, dizziness, kidney disorder, impotence and premature ejaculation; for preventing cerebral aging; for improving memory, cerebral functions; or for curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease, autism, brain trauma, Parkinson's disease or other diseases caused by cerebral dysfunctions, and treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, dizziness, kidney disorder. This invention provides compounds comprising at least one sugar, a triterpene, such as Sapogenin, and at least one side chains at Carbon 21 and 22, such as Angeloyl groups. The compounds of the present have various pharmaceutical and therapeutic applications.

摘要翻译： 本发明提供了从山茱萸生产提取物的组合物，方法和方法。 提取物包括生物碱，香豆素，糖类，蛋白质，多糖，糖苷，皂苷，单宁，酸，黄酮等。 该组合物可用于治疗癌症，关节炎，风湿病，循环不良，动脉硬化，雷诺综合征，心绞痛，心脏病，冠心病，头痛，头晕，肾脏疾病，阳ence和早泄; 用于预防脑衰老; 改善记忆力，脑功能; 或用于治疗遗尿，频繁排尿，尿失禁，痴呆，弱智能和阿尔茨海默病，自闭症，脑外伤，帕金森病或由脑功能障碍引起的其他疾病，以及治疗关节炎，风湿病，循环不良，动脉硬化，雷诺综合征，心绞痛 ，心脏病，冠心病，头痛，头晕，肾脏疾病。 本发明提供了包含至少一种糖，三萜类，例如皂角蛋白原的化合物和在碳21和22的至少一个侧链如阴离子基团的化合物。 本发明的化合物具有各种药物和治疗应用。

公开(公告)号：US20100317606A1

公开(公告)日：2010-12-16

申请号：US12856322

申请日：2010-08-13

申请人： Pui-Kwong CHAN ,  May Sung MAK

发明人： Pui-Kwong CHAN ,  May Sung MAK

IPC分类号： A61K31/704 ,  A61P37/04 ,  A61P35/00

CPC分类号： C07H15/256 ,  A61K31/7012 ,  A61K31/704 ,  A61K36/77 ,  C07C35/44 ,  C07H15/24 ,  Y02A50/409 ,  Y02A50/411

摘要： This invention provides methods, processes, compounds and compositions for modulating the gene expression or secretion of adhesion proteins, angiopoietins or their receptors to cure diseases, for anti-angiogenesis and for treating parasites, wherein the adhesion proteins or receptors comprise fibronectin, integrins family, myosin, vitronectin, collagen, laminin, glycosylation cell surface proteins, polyglycans, cadherin, heparin, tenascin, CD 54, CAM, elastin and FAK; wherein the angiopoietins comprise angiopoietin 1, angiopoietin 2, angiopoietin 3, angiopoietin 4, angiopoietin 5, angiopoietin 6, angiopoietin 7, angiopoietin-like 1, angiopoietin-like 2, angiopoietin-like 3, angiopoietin-like 4, angiopoietin-like 5, angiopoietin-like 6, and angiopoietin-like 7; wherein the cancers comprise breast cancer, leukocyte cancer, liver cancer, ovarian cancer, bladder cancer, prostate cancer, skin cancer, bone cancer, brain cancer, leukemia cancer, lung cancer, colon cancer, CNS cancer, melanoma cancer, renal cancer, cervical cancer, esophageal cancer, testicular cancer, spleenic cancer, kidney cancer, lymphatic cancer, pancreas cancer, stomach cancer and thyroid cancer.

摘要翻译： 本发明提供用于调节粘附蛋白，血管生成素或其受体的基因表达或分泌以治愈疾病，用于抗血管生成和用于治疗寄生虫的方法，方法，化合物和组合物，其中所述粘附蛋白或受体包含纤连蛋白，整联蛋白家族， 肌球蛋白，玻连蛋白，胶原，层粘连蛋白，糖基化细胞表面蛋白，聚糖，钙粘蛋白，肝素，腱生蛋白，CD 54，CAM，弹性蛋白和FAK; 其中血管生成素包括血管生成素1，血管生成素2，血管生成素3，血管生成素4，血管生成素5，血管生成素6，血管生成素7，血管生成素样1，血管生成素样2，血管生成素样3，血管生成素样4，血管生成素样5， 血管生成素样6和血管生成素样7; 其中癌症包括乳腺癌，白细胞癌，肝癌，卵巢癌，膀胱癌，前列腺癌，皮肤癌，骨癌，脑癌，白血病癌，肺癌，结肠癌，CNS癌，黑素瘤，肾癌，宫颈癌 癌症，食管癌，睾丸癌，脾癌，肾癌，淋巴癌，胰腺癌，胃癌和甲状腺癌。

公开(公告)号：US20100004190A1

公开(公告)日：2010-01-07

申请号：US12541713

申请日：2009-08-14

申请人： Pui-Kwong CHAN ,  May Sung MAK

发明人： Pui-Kwong CHAN ,  May Sung MAK

IPC分类号： A61K31/704 ,  A61K31/215

CPC分类号： C07H15/256 ,  A61K9/0019 ,  A61K31/704 ,  A61K31/7048 ,  C07C2603/54

摘要： This invention provides methods, processes, compounds and compositions for modulating the gene expression and modulating the secretion, expression, or synthesis of adhesion proteins or their receptors to cure disease, wherein the modulating comprises positive and negative regulating; wherein comprises inhibiting cancer growth, wherein the adhesion proteins or receptors comprise fibronectin, integrins family, Myosin, vitronectin, collagen, laminin, Glycosylation cell surface proteins, polyglycans, cadherin, heparin, tenascin, CD 54, CAM, elastin and FAK; wherein the methods, processes, compounds and compositions are also for anti-angiogenesis; wherein the cancers comprise breast cancer, leukocyte cancer, liver cancer, ovarian cancer, bladder cancer, prostate cancer, skin cancer, bone cancer, brain cancer, leukemia cancer, lung cancer, colon cancer, CNS cancer, melanoma cancer, renal cancer or cervix cancer.

摘要翻译： 本发明提供用于调节基因表达并调节粘附蛋白或其受体的分泌，表达或合成以治愈疾病的方法，方法，化合物和组合物，其中调节包括阳性和阴性调节; 其中包括抑制癌症生长，其中所述粘附蛋白或受体包括纤连蛋白，整联蛋白家族，肌球蛋白，玻连蛋白，胶原，层粘连蛋白，糖基化细胞表面蛋白，聚糖，钙粘着素，肝素，腱生蛋白，CD 54，CAM，弹性蛋白和FAK; 其中所述方法，方法，化合物和组合物也用于抗血管发生; 其中癌症包括乳腺癌，白细胞癌，肝癌，卵巢癌，膀胱癌，前列腺癌，皮肤癌，骨癌，脑癌，白血病癌，肺癌，结肠癌，CNS癌，黑素瘤，肾癌或子宫颈 癌症。