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公开(公告)号：US10704992B2
公开(公告)日：2020-07-07
申请号：US16395931
申请日：2019-04-26
发明人： Kenneth Jeffrey Hayworth , Richard Schalek , Juan Carlos Tapia , Narayanan Kasthuri , Jeff W. Lichtman
摘要： Methods, apparatuses and systems for facilitating automated or semi-automated collection of tissue samples cut by a microtome. In one example, a collection apparatus may be moved back and forth between respective positions at which the collection apparatus is operatively coupled to a microtome so as to collect cut tissue samples, or routine access to the microtome is provided. Relatively easy movement and positioning of the collection apparatus is facilitated, while at the same time ensuring structural stability and appropriate alignment and/or isolation between the collection apparatus and the microtome. A fluid reservoir receives samples cut by the microtome, and the collection apparatus may collect samples via a conveyor-like substrate disposed near/in the reservoir. A linear movement of the substrate may be controlled based on a cutting rate of the microtome, and the fluid level in the reservoir may be automatically maintained to facilitate effective sample collection.
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2.发明申请公开(公告)号：US20160139007A1
公开(公告)日：2016-05-19
申请号：US15005431
申请日：2016-01-25
IPC分类号： G01N1/06
CPC分类号： G01N1/06 , G01N1/286 , G01N1/312 , G01N2001/066 , G01N2001/362 , H01J2237/201 , H01J2237/202 , H01J2237/26 , Y10T156/1052 , Y10T156/1056 , Y10T156/1057 , Y10T156/1059 , Y10T156/1062 , Y10T156/12 , Y10T156/1322 , Y10T156/1712
摘要： Methods, apparatus and systems for collecting thin tissue samples for imaging. Thin tissue sections may be cut from tissue samples using a microtome-quality knife. In one example, tissue samples are mounted to a substrate that is rotated such that thin tissue sections are acquired via lathing. Collection of thin tissue sections may be facilitated by a conveyor belt. Thin tissue sections may be mounted to a thin substrate (e.g., by adhering thin tissue sections to a thin substrate via a roller mechanism) that may be imaged, for example, by an electron beam (e.g., in an electron microscope). Thin tissue sections may be strengthened before cutting via a blockface thinfilm deposition technique and/or a blockface taping technique. An automated reel-to-reel imaging technique may be employed for collected/mounted tissue sections to facilitate random-access imaging of tissue sections and maintaining a comprehensive library including a large volume of samples.
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公开(公告)号：US20180080856A1
公开(公告)日：2018-03-22
申请号：US15670784
申请日：2017-08-07
发明人： Kenneth Jeffrey Hayworth , Richard Schalek , Juan Carlos Tapia , Narayanan Kasthuri , Jeff Lichtman
CPC分类号： G01N1/06 , A61B16/00 , G01N35/00009 , G01N2001/061 , G01N2001/065 , G01N2001/066 , G01N2001/068
摘要： Methods, apparatuses and systems for facilitating automated or semi-automated collection of tissue samples cut by a microtome. In one example, a collection apparatus may be moved back and forth between respective positions at which the collection apparatus is operatively coupled to a microtome so as to collect cut tissue samples, or routine access to the microtome is provided. Relatively easy movement and positioning of the collection apparatus is facilitated, while at the same time ensuring structural stability and appropriate alignment and/or isolation between the collection apparatus and the microtome. A fluid reservoir receives samples cut by the microtome, and the collection apparatus may collect samples via a conveyor-like substrate disposed near/in the reservoir. A linear movement of the substrate may be controlled based on a cutting rate of the microtome, and the fluid level in the reservoir may be automatically maintained to facilitate effective sample collection.
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公开(公告)号：US10288532B2
公开(公告)日：2019-05-14
申请号：US15670784
申请日：2017-08-07
发明人： Kenneth Jeffrey Hayworth , Richard Schalek , Juan Carlos Tapia , Narayanan Kasthuri , Jeff Lichtman
摘要： Methods, apparatuses and systems for facilitating automated or semi-automated collection of tissue samples cut by a microtome. In one example, a collection apparatus may be moved back and forth between respective positions at which the collection apparatus is operatively coupled to a microtome so as to collect cut tissue samples, or routine access to the microtome is provided. Relatively easy movement and positioning of the collection apparatus is facilitated, while at the same time ensuring structural stability and appropriate alignment and/or isolation between the collection apparatus and the microtome. A fluid reservoir receives samples cut by the microtome, and the collection apparatus may collect samples via a conveyor-like substrate disposed near/in the reservoir. A linear movement of the substrate may be controlled based on a cutting rate of the microtome, and the fluid level in the reservoir may be automatically maintained to facilitate effective sample collection.
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5.发明申请METHODS, APPARATUS AND SYSTEMS FOR PRODUCTION, COLLECTION, HANDLING, AND IMAGING OF TISSUE SECTIONS 有权方法，组织部分的生产，收集，处理和成像的装置和系统公开(公告)号：US20130216451A1
公开(公告)日：2013-08-22
申请号：US13734121
申请日：2013-01-04
IPC分类号： G01N1/28
CPC分类号： G01N1/06 , G01N1/286 , G01N1/312 , G01N2001/066 , G01N2001/362 , H01J2237/201 , H01J2237/202 , H01J2237/26 , Y10T156/1052 , Y10T156/1056 , Y10T156/1057 , Y10T156/1059 , Y10T156/1062 , Y10T156/12 , Y10T156/1322 , Y10T156/1712
摘要： Methods, apparatus and systems for collecting thin tissue samples for imaging. Thin tissue sections may be cut from tissue samples using a microtome-quality knife. In one example, tissue samples are mounted to a substrate that is rotated such that thin tissue sections are acquired via lathing. Collection of thin tissue sections may be facilitated by a conveyor belt. Thin tissue sections may be mounted to a thin substrate (e.g., by adhering thin tissue sections to a thin substrate via a roller mechanism) that may be imaged, for example, by an electron beam (e.g., in an electron microscope). Thin tissue sections may be strengthened before cutting via a blockface thinfilm deposition technique and/or a blockface taping technique. An automated reel-to-reel imaging technique may be employed for collected/mounted tissue sections to facilitate random-access imaging of tissue sections and maintaining a comprehensive library including a large volume of samples.
摘要翻译： 用于收集用于成像的薄组织样本的方法，装置和系统。 可以使用切片机质量刀从组织样品切割薄组织切片。 在一个实例中，将组织样品安装到旋转的基底上，使得通过车床获得薄的组织切片。 通过传送带可以促进薄组织切片的收集。 薄组织切片可以例如通过电子束（例如，在电子显微镜中）被安装到薄基底（例如，通过将薄组织切片通过辊机构粘附到薄基底上）。 在通过块状薄膜沉积技术和/或块状胶带技术切割之前可以加强薄组织切片。 可以采用自动卷线对卷成像技术来收集/安装的组织切片，以促进组织切片的随机取景成像并维持包括大量样品的综合库。
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6.发明授权公开(公告)号：US09927327B2
公开(公告)日：2018-03-27
申请号：US15005431
申请日：2016-01-25
CPC分类号： G01N1/06 , G01N1/286 , G01N1/312 , G01N2001/066 , G01N2001/362 , H01J2237/201 , H01J2237/202 , H01J2237/26 , Y10T156/1052 , Y10T156/1056 , Y10T156/1057 , Y10T156/1059 , Y10T156/1062 , Y10T156/12 , Y10T156/1322 , Y10T156/1712
摘要： Methods, apparatus and systems for collecting thin tissue samples for imaging. Thin tissue sections may be cut from tissue samples using a microtome-quality knife. In one example, tissue samples are mounted to a substrate that is rotated such that thin tissue sections are acquired via lathing. Collection of thin tissue sections may be facilitated by a conveyor belt. Thin tissue sections may be mounted to a thin substrate (e.g., by adhering thin tissue sections to a thin substrate via a roller mechanism) that may be imaged, for example, by an electron beam (e.g., in an electron microscope). Thin tissue sections may be strengthened before cutting via a blockface thinfilm deposition technique and/or a blockface taping technique. An automated reel-to-reel imaging technique may be employed for collected/mounted tissue sections to facilitate random-access imaging of tissue sections and maintaining a comprehensive library including a large volume of samples.
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公开(公告)号：US11085853B2
公开(公告)日：2021-08-10
申请号：US16921076
申请日：2020-07-06
发明人： Kenneth Jeffrey Hayworth , Richard Schalek , Juan Carlos Tapia , Narayanan Kasthuri , Jeff W. Lichtman
摘要： Methods, apparatuses and systems for facilitating automated or semi-automated collection of tissue samples cut by a microtome. In one example, a collection apparatus may be moved back and forth between respective positions at which the collection apparatus is operatively coupled to a microtome so as to collect cut tissue samples, or routine access to the microtome is provided. Relatively easy movement and positioning of the collection apparatus is facilitated, while at the same time ensuring structural stability and appropriate alignment and/or isolation between the collection apparatus and the microtome. A fluid reservoir receives samples cut by the microtome, and the collection apparatus may collect samples via a conveyor-like substrate disposed near/in the reservoir. A linear movement of the substrate may be controlled based on a cutting rate of the microtome, and the fluid level in the reservoir may be automatically maintained to facilitate effective sample collection.
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公开(公告)号：US20190250071A1
公开(公告)日：2019-08-15
申请号：US16395931
申请日：2019-04-26
发明人： Kenneth Jeffrey Hayworth , Richard Schalek , Juan Carlos Tapia , Narayanan Kasthuri , Jeff W. Lichtman
CPC分类号： G01N1/06 , A61B16/00 , G01N35/00009 , G01N2001/061 , G01N2001/065 , G01N2001/066 , G01N2001/068
摘要： Methods, apparatuses and systems for facilitating automated or semi-automated collection of tissue samples cut by a microtome. In one example, a collection apparatus may be moved back and forth between respective positions at which the collection apparatus is operatively coupled to a microtome so as to collect cut tissue samples, or routine access to the microtome is provided. Relatively easy movement and positioning of the collection apparatus is facilitated, while at the same time ensuring structural stability and appropriate alignment and/or isolation between the collection apparatus and the microtome. A fluid reservoir receives samples cut by the microtome, and the collection apparatus may collect samples via a conveyor-like substrate disposed near/in the reservoir. A linear movement of the substrate may be controlled based on a cutting rate of the microtome, and the fluid level in the reservoir may be automatically maintained to facilitate effective sample collection.
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