公开(公告)号：US09631171B2

公开(公告)日：2017-04-25

申请号：US13989024

申请日：2011-11-22

申请人： Pranav Soman ,  Shaochen Chen ,  David Fozdar

发明人： Pranav Soman ,  Shaochen Chen ,  David Fozdar

IPC分类号： C12N5/00 ,  A61L27/14 ,  A61L27/40 ,  A61L27/52 ,  A61L27/56 ,  B29C67/00

CPC分类号： C12N5/00 ,  A61L27/14 ,  A61L27/40 ,  A61L27/52 ,  A61L27/56 ,  A61L2400/08 ,  A61L2400/12 ,  A61L2400/18 ,  B29C64/165 ,  B33Y80/00

摘要： Methods and systems for fabricating a micro-structured biomaterial include printing a three-dimensional structure using polymerizing radiation modulated by a digital micromirror array to project microstructure patterns into a pre-polymer material to form one or more porous scaffold sheets. The microstructure patterns have a unit-cell geometry that exhibits a negative Poisson ratio that is tunable in magnitude.

公开(公告)号：US20130344601A1

公开(公告)日：2013-12-26

申请号：US13989024

申请日：2011-11-22

申请人： Pranav Soman ,  Shaochen Chen ,  David Fozdar

发明人： Pranav Soman ,  Shaochen Chen ,  David Fozdar

IPC分类号： C12N5/00 ,  B29C67/00

CPC分类号： C12N5/00 ,  A61L27/14 ,  A61L27/40 ,  A61L27/52 ,  A61L27/56 ,  A61L2400/08 ,  A61L2400/12 ,  A61L2400/18 ,  B29C64/165 ,  B33Y80/00

摘要： Techniques, systems, apparatus and material are disclosed for fabricating a micro-structured biomaterial. In one aspect, a micro-structured biomaterial includes a three-dimensional solid-phase micro-cellular biomaterial that exhibits a negative Poisson ratio that is tunable in magnitude.

摘要翻译： 公开了用于制造微结构生物材料的技术，系统，装置和材料。 在一个方面，微结构生物材料包括三维固相微细胞生物材料，其表现出可以在数量上可调的负泊松比。

公开(公告)号：US20240309196A1

公开(公告)日：2024-09-19

申请号：US18605027

申请日：2024-03-14

申请人： Pranav Soman ,  Puskal Kunwar

发明人： Pranav Soman ,  Puskal Kunwar

IPC分类号： C08L33/26 ,  B29C35/08 ,  B29C64/124 ,  B29C64/209 ,  B29C64/245 ,  B29C64/268 ,  B29C64/295 ,  B29K33/00 ,  B29K105/00 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y40/20 ,  B33Y70/00 ,  C08J3/075

CPC分类号： C08L33/26 ,  B29C64/124 ,  B29C64/245 ,  B29C64/268 ,  B29C64/295 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y40/20 ,  B33Y70/00 ,  C08J3/075 ,  B29C2035/0838 ,  B29C64/209 ,  B29K2033/26 ,  B29K2105/0002 ,  B29K2105/0061 ,  C08J2333/26 ,  C08J2405/00

摘要： An apparatus and method for shaping double-network hydrogels into customized 3D structures. A one-pot prepolymer formulation containing photo-cross-linkable acrylamide and thermoreversible sol-gel κ-carrageenan with a suitable crosslinker, and photo-initiator/absorbers was used. The formulation was polymerized using a TOPS system with heating stage to photo-polymerize the primary acrylamide network into a 3D structure above the sol-gel transition of κ-carrageenan (80° C.). Cooling down then generates the secondary physical κ-carrageenan network to realize tough double-network hydrogel structures. Printed 3D structures had superior lateral (37 μm) and vertical (180 μm) resolutions and 3D design freedoms (internal voids) that exhibit ultimate stress and strain of 200 kPa and 2400% respectively under tension, and simultaneously exhibit high compression stress of 15 MPa with a strain of 95%, both with high recovery rates. The apparatus and method can be employed with other double-network hydrogels to make multifunctional soft devices for a range of applications.

公开(公告)号：US11745427B2

公开(公告)日：2023-09-05

申请号：US17673874

申请日：2022-02-17

申请人： Pranav Soman ,  Puskal Kunwar ,  Zheng Xiong

发明人： Pranav Soman ,  Puskal Kunwar ,  Zheng Xiong

IPC分类号： B29C64/135 ,  B29C64/277 ,  G02F1/37 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00

CPC分类号： B29C64/277 ,  B29C64/135 ,  G02F1/372 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00

摘要： A hybrid laser printing (HLP) technology that utilizes ultrafast laser in sequential additive-subtractive modes to create 3D hydrogel constructs. The approach involves the synergistic use of additive crosslinking and subtractive ablation processes that are conventionally mutually exclusive. HLP can be operated at virtually any penetration depth and allow fabrication of multi-layer hydrogel constructs at micrometer resolution. HLP was used to print ready-to-use functional chips using commonly used hydrogels for potential cellular communication and migration applications. HLP was also found to be compatible with in situ printing of cell-laden hydrogel constructs. HLP makes shaping of soft hydrogels into 3D multiscale functional devices possible.

公开(公告)号：US20220168955A1

公开(公告)日：2022-06-02

申请号：US17673874

申请日：2022-02-17

申请人： Pranav Soman ,  Puskal Kunwar ,  Zheng Xiong

发明人： Pranav Soman ,  Puskal Kunwar ,  Zheng Xiong

IPC分类号： B29C64/277 ,  B29C64/135 ,  G02F1/37

摘要： A hybrid laser printing (HLP) technology that utilizes ultrafast laser in sequential additive-subtractive modes to create 3D hydrogel constructs. The approach involves the synergistic use of additive crosslinking and subtractive ablation processes that are conventionally mutually exclusive. HLP can be operated at virtually any penetration depth and allow fabrication of multi-layer hydrogel constructs at micrometer resolution. HLP was used to print ready-to-use functional chips using commonly used hydrogels for potential cellular communication and migration applications. HLP was also found to be compatible with in situ printing of cell-laden hydrogel constructs. HLP makes shaping of soft hydrogels into 3D multiscale functional devices possible.

公开(公告)号：US11260596B2

公开(公告)日：2022-03-01

申请号：US16973235

申请日：2019-07-11

申请人： Pranav Soman ,  Puskal Kunwar ,  Zheng Xiong

发明人： Pranav Soman ,  Puskal Kunwar ,  Zheng Xiong

IPC分类号： B29C64/277 ,  B29C64/135 ,  G02F1/37 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y70/00

摘要： A hybrid laser printing (HLP) technology that utilizes ultrafast laser in sequential additive-subtractive modes to create 3D hydrogel constructs. The approach involves the synergistic use of additive crosslinking and subtractive ablation processes that are conventionally mutually exclusive. HLP can be operated at virtually any penetration depth and allow fabrication of multi-layer hydrogel constructs at micrometer resolution. HLP was used to print ready-to-use functional chips using commonly used hydrogels for potential cellular communication and migration applications. HLP was also found to be compatible with in situ printing of cell-laden hydrogel constructs. HLP makes shaping of soft hydrogels into 3D multi scale functional devices possible.

公开(公告)号：US20210237354A1

公开(公告)日：2021-08-05

申请号：US16973235

申请日：2019-07-11

申请人： Pranav Soman ,  Puskal Kunwar ,  Zheng Xiong

发明人： Pranav Soman ,  Puskal Kunwar ,  Zheng Xiong

IPC分类号： B29C64/277 ,  G02F1/37 ,  B29C64/135

摘要： A hybrid laser printing (HLP) technology that utilizes ultrafast laser in sequential additive-subtractive modes to create 3D hydrogel constructs. The approach involves the synergistic use of additive crosslinking and subtractive ablation processes that are conventionally mutually exclusive. HLP can be operated at virtually any penetration depth and allow fabrication of multi-layer hydrogel constructs at micrometer resolution. HLP was used to print ready-to-use functional chips using commonly used hydrogels for potential cellular communication and migration applications. HLP was also found to be compatible with in situ printing of cell-laden hydrogel constructs. HLP makes shaping of soft hydrogels into 3D multi scale functional devices possible.