公开(公告)号：US20210024516A1

公开(公告)日：2021-01-28

申请号：US16809244

申请日：2020-03-04

申请人： Pliant Therapeutics, Inc.

发明人： Lan JIANG ,  David John MORGANS, Jr. ,  Gustave BERGNES ,  Chun CHEN ,  Hui LI ,  Patrick ANDRE ,  Randall HALCOMB ,  Jacob CHA ,  Timothy HOM

IPC分类号： C07D471/04 ,  A61P1/16 ,  A61P9/00 ,  A61P17/00 ,  A61P13/12 ,  A61P1/00 ,  A61P11/00 ,  C07D213/74 ,  C07D233/70 ,  C07D233/88 ,  C07D241/06 ,  C07D241/08 ,  C07D263/28 ,  C07D265/08 ,  C07D277/18 ,  C07D279/06

摘要： The invention relates to compounds of formula (I): or a salt thereof, wherein R1, A, L, and R2 and n are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are αvβ1 integrin inhibitors that are useful for treating tissue specific fibrosis.