公开(公告)号：US20210122747A1

公开(公告)日：2021-04-29

申请号：US16894712

申请日：2020-06-05

申请人： Pliant Therapeutics, Inc.

发明人： David John MORGANS, Jr. ,  Randall L. HALCOMB ,  Gustave BERGNES ,  Hui LI ,  Lan JIANG ,  Jacob CHA ,  Timothy HOM

IPC分类号： C07D471/04

摘要： The invention relates to compounds of formula (I): or a salt thereof, wherein R1, R5, R7, R8. X, m, n, p and q are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are αvβ6 integrin inhibitors that are useful for treating tissue specific fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

公开(公告)号：US20240043421A1

公开(公告)日：2024-02-08

申请号：US18114979

申请日：2023-02-27

申请人： Pliant Therapeutics, Inc.

发明人： David John MORGANS, JR. ,  Randall L. HALCOMB ,  Gustave BERGNES ,  Hui LI ,  Lan JIANG ,  Jacob CHA ,  Timothy HOM

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： The invention relates to compounds of formula (I):




or a salt thereof, wherein R1, R5, R7, R8, X, m, n, p and q are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are αvβ6 integrin inhibitors that are useful for treating tissue specific fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSW).

公开(公告)号：US20190322663A1

公开(公告)日：2019-10-24

申请号：US16471521

申请日：2017-12-20

申请人： Pliant Therapeutics, Inc.

发明人： David John MORGANS, Jr. ,  Randall L. HALCOMB ,  Gustave BERGNES ,  Hui LI ,  Lan JIANG ,  Jacob CHA ,  Timothy HOM

IPC分类号： C07D471/04

摘要： The invention relates to compounds of formula (I): formula (I) or a salt thereof wherein R1, R5, R7, R8, X, m, n, p and q are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are αvβ6 integrin inhibitors that are useful for treating tissue specific fibrosis such as idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

公开(公告)号：US20230365556A1

公开(公告)日：2023-11-16

申请号：US18140520

申请日：2023-04-27

申请人： Pliant Therapeutics, Inc.

发明人： Lan JIANG ,  David John MORGANS, JR. ,  Gustave BERGNES ,  Chun CHEN ,  Hui LI ,  Patrick ANDRE ,  Randall L. HALCOMB ,  Jacob CHA ,  Timothy HOM

IPC分类号： C07D471/04 ,  A61P1/16 ,  A61P9/00 ,  A61P17/00 ,  A61P13/12 ,  A61P1/00 ,  A61P11/00 ,  C07D213/74 ,  C07D233/70 ,  C07D233/88 ,  C07D241/06 ,  C07D241/08 ,  C07D263/28 ,  C07D265/08 ,  C07D277/18 ,  C07D279/06

CPC分类号： C07D471/04 ,  A61P1/16 ,  A61P9/00 ,  A61P17/00 ,  A61P13/12 ,  A61P1/00 ,  A61P11/00 ,  C07D213/74 ,  C07D233/70 ,  C07D233/88 ,  C07D241/06 ,  C07D241/08 ,  C07D263/28 ,  C07D265/08 ,  C07D277/18 ,  C07D279/06

摘要： The invention relates to compounds of formula (I):




or a salt thereof, wherein R1, A, L, and R2 and n are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are αvβ1 integrin inhibitors that are useful for treating tissue specific fibrosis.

公开(公告)号：US20210024516A1

公开(公告)日：2021-01-28

申请号：US16809244

申请日：2020-03-04

申请人： Pliant Therapeutics, Inc.

发明人： Lan JIANG ,  David John MORGANS, Jr. ,  Gustave BERGNES ,  Chun CHEN ,  Hui LI ,  Patrick ANDRE ,  Randall HALCOMB ,  Jacob CHA ,  Timothy HOM

IPC分类号： C07D471/04 ,  A61P1/16 ,  A61P9/00 ,  A61P17/00 ,  A61P13/12 ,  A61P1/00 ,  A61P11/00 ,  C07D213/74 ,  C07D233/70 ,  C07D233/88 ,  C07D241/06 ,  C07D241/08 ,  C07D263/28 ,  C07D265/08 ,  C07D277/18 ,  C07D279/06

摘要： The invention relates to compounds of formula (I): or a salt thereof, wherein R1, A, L, and R2 and n are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are αvβ1 integrin inhibitors that are useful for treating tissue specific fibrosis.

公开(公告)号：US20180093984A1

公开(公告)日：2018-04-05

申请号：US15698435

申请日：2017-09-07

申请人： Pliant Therapeutics, Inc.

发明人： Lan JIANG ,  David John MORGANS, JR. ,  Gustave BERGNES ,  Chun CHEN ,  Hui LI ,  Patrick ANDRE ,  Randall L. HALCOMB ,  Jacob CHA ,  Timothy HOM

IPC分类号： C07D471/04 ,  C07D241/08 ,  C07D213/74 ,  C07D241/06 ,  C07D263/28 ,  C07D277/18 ,  C07D233/70 ,  C07D265/08 ,  C07D279/06 ,  C07D233/88 ,  A61P11/00 ,  A61P1/16 ,  A61P17/00 ,  A61P9/00 ,  A61P13/12 ,  A61P1/00

CPC分类号： C07D471/04 ,  A61P1/00 ,  A61P1/16 ,  A61P9/00 ,  A61P11/00 ,  A61P13/12 ,  A61P17/00 ,  C07D213/74 ,  C07D233/70 ,  C07D233/88 ,  C07D241/06 ,  C07D241/08 ,  C07D263/28 ,  C07D265/08 ,  C07D277/18 ,  C07D279/06

摘要： The invention relates to compounds of formula (I): or a salt thereof, wherein R1, A, L, and R2 and n are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are αvβ1 integrin inhibitors that are useful for treating tissue specific fibrosis.