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公开(公告)号：US09005634B2
公开(公告)日：2015-04-14
申请号：US13282532
申请日：2011-10-27
申请人： Phillip E. McDonald , Suping Lyu
发明人： Phillip E. McDonald , Suping Lyu
IPC分类号： A61K9/14 , A61K9/00 , A61K47/10 , A61K47/32 , A61K47/38 , A61K9/70 , A61K31/4168 , A61K31/445
CPC分类号： A61K9/0024 , A61K9/7007 , A61K31/4168 , A61K31/445 , A61K47/10 , A61K47/32 , A61K47/38
摘要： A pharmaceutical depot includes a biodegradable polymer having a glass transition temperature of 20 degrees centigrade or less and at least 25% wt solid particles suspended in the biodegradable polymer. The pharmaceutical depot also includes a post-operative pain relieving therapeutic agent.
摘要翻译： 药物贮库包括玻璃化转变温度为20摄氏度或更低的可生物降解的聚合物和悬浮在可生物降解聚合物中的至少25重量％的固体颗粒。 药剂库还包括术后止痛治疗剂。
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2.发明申请Compositions and Methods for Treating Post-Operative Pain Using Clonidine and Bupivacaine 有权使用可乐定和布比卡因治疗手术后疼痛的组合物和方法公开(公告)号：US20090263321A1
公开(公告)日：2009-10-22
申请号：US12420110
申请日：2009-04-08
IPC分类号： A61K51/04 , A61K31/445 , A61F2/04 , A61P25/00
CPC分类号： A61K9/0024 , A61K9/204 , A61K31/4168 , A61K31/445 , A61K45/06
摘要： Effective treatments of pain that accompanies post-operative surgeries are provided. Through the administration of an effective amount of a combination of bupivacaine and clonidine at or near a target site, one can alleviate or prevent pain. This administration of bupivacaine and clonidine or pharmaceutically acceptable salts thereof is particularly useful following surgery.
摘要翻译： 提供了伴随手术后手术的有效治疗疼痛。 通过在目标部位或其附近施用有效量的布比卡因和可乐定的组合，可以缓解或预防疼痛。 布比卡因和可乐定或其药学上可接受的盐的施用在手术后是特别有用的。
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公开(公告)号：US09132119B2
公开(公告)日：2015-09-15
申请号：US12412024
申请日：2009-03-26
IPC分类号： A61F2/00 , A61K31/415 , A61K9/00 , A61K9/16 , A61K9/06
CPC分类号： A61K31/4168 , A61K9/0019 , A61K9/0024 , A61K9/0085 , A61K9/06 , A61K9/1647 , A61K31/415 , A61K47/34
摘要： Effective treatments of acute pain for extended periods of time are provided. The treatments include the administration of one or more drug depots at or near a target site wherein the drug depots include an effective amount of clonidine formulated within a polyorthoester. By administration of one or more drug depots at or near the target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.
摘要翻译： 提供了长期急性疼痛的有效治疗方法。 治疗包括在靶位点处或附近施用一个或多个药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的可乐定。 通过管理目标部位处或附近的一个或多个药物库，可以减轻由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊柱脱位，狭窄，恶性背痛和关节疼痛 作为手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。
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4.发明授权Compositions and methods for treating post-operative pain using clonidine and bupivacaine 有权用可乐定和布比卡因治疗手术后疼痛的组合物和方法公开(公告)号：US09132085B2
公开(公告)日：2015-09-15
申请号：US12420110
申请日：2009-04-08
CPC分类号： A61K9/0024 , A61K9/204 , A61K31/4168 , A61K31/445 , A61K45/06
摘要： Effective treatments of pain that accompanies post-operative surgeries are provided. Through the administration of an effective amount of a combination of bupivacaine and clonidine at or near a target site, one can alleviate or prevent pain. This administration of bupivacaine and clonidine or pharmaceutically acceptable salts thereof is particularly useful following surgery.
摘要翻译： 提供了伴随手术后手术的有效治疗疼痛。 通过在目标部位或其附近施用有效量的布比卡因和可乐定的组合，可以缓解或预防疼痛。 布比卡因和可乐定或其药学上可接受的盐的施用在手术后是特别有用的。
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公开(公告)号：US20090263448A1
公开(公告)日：2009-10-22
申请号：US12412024
申请日：2009-03-26
IPC分类号： A61K9/00
CPC分类号： A61K31/4168 , A61K9/0019 , A61K9/0024 , A61K9/0085 , A61K9/06 , A61K9/1647 , A61K31/415 , A61K47/34
摘要： Effective treatments of acute pain for extended periods of time are provided. The treatments include the administration of one or more drug depots at or near a target site wherein the drug depots include an effective amount of clonidine formulated within a polyorthoester. By administration of one or more drug depots at or near the target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.
摘要翻译： 提供了长期急性疼痛的有效治疗方法。 治疗包括在靶位点处或附近施用一个或多个药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的可乐定。 通过管理目标部位处或附近的一个或多个药物库，可以减轻由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊柱脱位，狭窄，恶性背痛和关节疼痛 作为手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。
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