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公开(公告)号：US20190269791A1
公开(公告)日：2019-09-05
申请号：US16342275
申请日：2017-10-03
申请人： Pfizer Inc.
发明人： Andrea Therese HOOPER , Kimberly Ann MARQUETTE , Chakrapani SUBRAMANYAM , Hans-Peter GERBER , Chad Michael MAY
摘要： The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same.
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公开(公告)号：US20240261423A1
公开(公告)日：2024-08-08
申请号：US18528539
申请日：2023-12-04
申请人： Pfizer Inc.
发明人： Andrea Therese HOOPER , Kimberly Ann MARQUETTE , Chakrapani SUBRAMANYAM , Hans-Peter GERBER , Chad Michael MAY
CPC分类号： A61K47/6803 , A61K47/6843 , A61P35/00 , C07K16/18 , A61K38/08 , A61K47/6811 , C07K2317/21 , C07K2317/33 , C07K2317/52 , C07K2317/565 , C07K2317/92
摘要： The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same.
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公开(公告)号：US20170151341A1
公开(公告)日：2017-06-01
申请号：US15356750
申请日：2016-11-21
申请人： Pfizer Inc.
发明人： Dangshe MA , Frank LOGANZO, JR. , Kimberly Ann MARQUETTE , Edmund Idris GRAZIANI , Puja SAPRA , Pavel STROP
摘要： The present invention provides site specific HER2 antibody drug conjugates and methods for preparing and using the same.
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公开(公告)号：US20240156977A1
公开(公告)日：2024-05-16
申请号：US18492348
申请日：2023-10-23
申请人： Pfizer Inc.
发明人： Andrea Therese HOOPER , Kimberly Ann MARQUETTE , Chakrapani SUBRAMANYAM , Hans-Peter GERBER , Chad Michael MAY
CPC分类号： A61K47/6803 , A61K47/6843 , A61P35/00 , C07K16/18 , A61K38/08 , A61K47/6811
摘要： The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same.
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公开(公告)号：US20240117030A1
公开(公告)日：2024-04-11
申请号：US18175796
申请日：2023-02-28
申请人： Pfizer Inc.
发明人： Rita Diane AGOSTINELLI , James Reasoner APGAR , Eric Matthew BENNETT , Laird BLOOM , Ting CHEN , Aaron Michael D'ANTONA , Arnab DE , Fang JIN , Marion Teresa KASAIAN , Matthew Allister LAMBERT , Kimberly Ann MARQUETTE , Virginie MCMANUS , Jessica Haewon MIN DEBARTOLO , Nicole Melissa PICHE-NICHOLAS , Richard Thomas SHELDON , Lioudmila TCHISTIAKOVA , Alexander Michael Shuford BARRON , Richard Lee GIESECK, III , Xiaotian ZHONG
CPC分类号： C07K16/247 , A61K45/06 , A61P35/00 , A61K2039/505
摘要： The present invention relates to antibodies that specifically bind to one or more of IL-4, IL-13, IL-33, TSLP, and p40. The present invention further relates to antibodies that bind to one of IL-4, IL-13, IL-33, or TSLP. The invention further relates to multispecific antibodies that specifically bind to IL-4 and IL-13, and at least one other target. The present invention relates to multispecific antibodies that bind IL-4, IL-13, and one of IL-33, TSLP, or p40. The present invention also pertains to related molecules, e.g. nucleic acids which encode such antibodies or multispecific antibodies, compositions, and related methods, e.g., methods for producing and purifying such antibodies and multispecific antibodies, and their use in diagnostics and therapeutics.
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公开(公告)号：US20230241235A1
公开(公告)日：2023-08-03
申请号：US18166774
申请日：2023-02-09
申请人： Pfizer Inc.
发明人： Andrea Therese HOOPER , Kimberly Ann MARQUETTE , Chakrapani SUBRAMANYAM , Hans-Peter GERBER , Chad Michael MAY
CPC分类号： A61K47/6811 , A61K47/6843 , A61P35/00 , A61K38/08 , C07K16/18 , A61K47/6803 , C07K2317/21 , C07K2317/52 , C07K2317/565 , C07K2317/33 , C07K2317/92
摘要： The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same.
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公开(公告)号：US20200377615A1
公开(公告)日：2020-12-03
申请号：US16891460
申请日：2020-06-03
申请人： Pfizer Inc.
发明人： Dangshe MA , Frank LOGANZO, Jr. , Kimberly Ann MARQUETTE , Edmund Idris GRAZIANI , Puja SAPRA , Pavel STROP
摘要： The present invention provides site specific HER2 antibody drug conjugates and methods for preparing and using the same.
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公开(公告)号：US20240181071A1
公开(公告)日：2024-06-06
申请号：US18492055
申请日：2023-10-23
申请人： Pfizer Inc.
发明人： Andrea Therese HOOPER , Kimberly Ann MARQUETTE , Chakrapani SUBRAMANYAM , Hans-Peter GERBER , Chad Michael MAY
CPC分类号： A61K47/6803 , A61K47/6843 , A61P35/00 , C07K16/18 , A61K38/08 , A61K47/6811
摘要： The present invention provides antibodies and antibody-drug conjugates that bind to the extra domain B splice variant of fibronectin 1 and methods for preparing and using the same.
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公开(公告)号：US20240059799A1
公开(公告)日：2024-02-22
申请号：US18314339
申请日：2023-05-09
发明人： James Reasoner APGAR , Laird BLOOM , Fang JIN , Fridrik KARLSSON , Kimberly Ann MARQUETTE , Jessica Haewon MIN DEBARTOLO , Nicole Melissa PICHE-NICHOLAS , Lioudmila TCHISTIAKOVA
CPC分类号： C07K16/468 , A61P37/02 , C12N15/63 , C07K2317/14 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： The present invention discloses an isolated antibody that specifically binds to TL1A, comprising a heavy chain variable region (TL1A-VH) and a light chain variable region (TL1A-VL), comprising the CDR-H1, CDR-H2, and CDR-H3 sequences of a TL1A-VH sequence selected from the group consisting of SEQ ID NO: 42, SEQ ID NO: 44, SEQ ID NO: 47, SEQ ID NO: 49, SEQ ID NO: 52, SEQ ID NO: 54, SEQ ID NO: 57, SEQ ID NO: 70, SEQ ID NO: 72, SEQ ID NO: 78, SEQ ID NO: 80, SEQ ID NO: 89, SEQ ID NO: 93, SEQ ID NO: 95, SEQ ID NO: 97, SEQ ID NO: 99, SEQ ID NO: 101, SEQ ID NO: 103, SEQ ID NO: 105, SEQ ID NO: 110, SEQ ID NO: 120; and the CDR-L1, CDR-L2, and CDR-L3 sequences of SEQ ID NO: 18.
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公开(公告)号：US20220119545A1
公开(公告)日：2022-04-21
申请号：US17292257
申请日：2019-11-07
发明人： Lewis C. CANTLEY , Stephen P. SOLTOFF , Brooke M. EMERLING , George POULOGIANNIS , Cindy M. HODAKOSKI , Hui LIU , Irina APOSTOLOU , Brian Gaither BATES , Kimberly Ann MARQUETTE , Eric M. BENNETT , Lidia MOSYAK , Lioudmila G. TCHISTIAKOVA , Edward Christian ROSFJORD , Isaac J. RONDON , Chao Bai HUANG
摘要： The present disclosure provides materials and methods for CUB domain-containing protein 1 (CDCP1)-targeted therapy.
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