公开(公告)号：US20040009560A1

公开(公告)日：2004-01-15

申请号：US10412444

申请日：2003-06-11

申请人： Pfizer Inc.

发明人： Kim J. Stutzman-Engwall ,  Chen Yan ,  Claes Gustafsson ,  Anke Krebber ,  Jeremy Minshull ,  Sun Ai Raillard

IPC分类号： C12P019/62 ,  C07H021/04 ,  C12N009/10 ,  C12N001/21 ,  C12P021/02 ,  C12N015/74

CPC分类号： C12P17/181 ,  C12N9/88 ,  C12P19/623

摘要： The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.

摘要翻译： 本发明涉及包含编码aveC基因产物的核苷酸序列的多核苷酸分子，所述多核苷酸分子可用于改变阿维链霉菌发酵培养物中产生的2:1级阿凡曼菌素的比例或量。 本发明还涉及阿维链霉菌的载体，宿主细胞和突变菌株，其中aveC基因已被灭活，或突变以改变所产生的2:1级除虫菌素的比例或量。

公开(公告)号：US20030232415A1

公开(公告)日：2003-12-18

申请号：US10412450

申请日：2003-06-11

申请人： Pfizer Inc.

发明人： Kim J. Stutzman-Engwall ,  Yan Chen ,  Claes Gustafsson ,  Anke Krebber ,  Jeremy Minshull ,  Sun Ai Raillard

IPC分类号： C12P019/62 ,  C07H021/04 ,  C12N009/10 ,  C12P021/02 ,  C12N001/21 ,  C12N015/74

CPC分类号： C12P17/181 ,  C12N9/88 ,  C12P19/623

摘要： The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains of S. avermitilis in which the aveC gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.

摘要翻译： 本发明涉及包含编码aveC基因产物的核苷酸序列的多核苷酸分子，所述多核苷酸分子可用于改变阿维链霉菌发酵培养物中产生的2:1级阿凡曼菌素的比例或量。 本发明还涉及阿维链霉菌的载体，宿主细胞和突变菌株，其中aveC基因已被灭活，或突变以改变所产生的2:1级除虫菌素的比例或量。