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公开(公告)号:US08674078B2
公开(公告)日:2014-03-18
申请号:US13443652
申请日:2012-04-10
IPC分类号: C07K16/00 , A61K39/395
CPC分类号: C07K14/70503 , C07K2319/30
摘要: The invention provides isolated BTL-II proteins, nucleic acids, antibodies, antagonists, and agonists and methods of making and using the same. Diagnostic, screening, and therapeutic methods using the compositions of the invention are provided. For example, the compositions of the invention can be used for diagnosis and treatment of inflammatory bowel diseases and for enhancing a mucosal immune response to an antigen.
摘要翻译: 本发明提供了分离的BTL-II蛋白,核酸,抗体,拮抗剂和激动剂以及制备和使用它们的方法。 提供使用本发明组合物的诊断,筛选和治疗方法。 例如,本发明的组合物可用于炎症性肠病的诊断和治疗以及增强对抗原的粘膜免疫应答。
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公开(公告)号:US08173603B2
公开(公告)日:2012-05-08
申请号:US12716594
申请日:2010-03-03
IPC分类号: A61K38/17
CPC分类号: C07K14/70503 , C07K2319/30
摘要: The invention provides isolated BTL-II proteins, nucleic acids, antibodies, antagonists, and agonists and methods of making and using the same. Diagnostic, screening, and therapeutic methods using the compositions of the invention are provided. For example, the compositions of the invention can be used for diagnosis and treatment of inflammatory bowel diseases and for enhancing a mucosal immune response to an antigen.
摘要翻译: 本发明提供了分离的BTL-II蛋白,核酸,抗体,拮抗剂和激动剂以及制备和使用它们的方法。 提供使用本发明组合物的诊断,筛选和治疗方法。 例如,本发明的组合物可用于炎症性肠病的诊断和治疗以及增强对抗原的粘膜免疫应答。
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公开(公告)号:US20100330104A1
公开(公告)日:2010-12-30
申请号:US12716594
申请日:2010-03-03
IPC分类号: A61K39/395 , A61K38/16 , A61P1/00 , C12N5/02
CPC分类号: C07K14/70503 , C07K2319/30
摘要: The invention provides isolated BTL-II proteins, nucleic acids, antibodies, antagonists, and agonists and methods of making and using the same. Diagnostic, screening, and therapeutic methods using the compositions of the invention are provided. For example, the compositions of the invention can be used for diagnosis and treatment of inflammatory bowel diseases and for enhancing a mucosal immune response to an antigen.
摘要翻译: 本发明提供了分离的BTL-II蛋白,核酸,抗体,拮抗剂和激动剂以及制备和使用它们的方法。 提供使用本发明组合物的诊断,筛选和治疗方法。 例如,本发明的组合物可用于炎症性肠病的诊断和治疗以及增强对抗原的粘膜免疫应答。
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公开(公告)号:US20120258097A1
公开(公告)日:2012-10-11
申请号:US13443652
申请日:2012-04-10
IPC分类号: A61K39/395 , A61P37/04 , C07K16/18
CPC分类号: C07K14/70503 , C07K2319/30
摘要: The invention provides isolated BTL-II proteins, nucleic acids, antibodies, antagonists, and agonists and methods of making and using the same. Diagnostic, screening, and therapeutic methods using the compositions of the invention are provided. For example, the compositions of the invention can be used for diagnosis and treatment of inflammatory bowel diseases and for enhancing a mucosal immune response to an antigen.
摘要翻译: 本发明提供了分离的BTL-II蛋白,核酸,抗体,拮抗剂和激动剂以及制备和使用它们的方法。 提供使用本发明组合物的诊断,筛选和治疗方法。 例如,本发明的组合物可用于炎症性肠病的诊断和治疗以及增强对抗原的粘膜免疫应答。
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公开(公告)号:US07244822B2
公开(公告)日:2007-07-17
申请号:US10742682
申请日:2003-12-19
IPC分类号: C07K14/435 , C07K14/705 , C07K14/725 , C07K16/46
CPC分类号: C07K14/70503 , C07K2319/30
摘要: The invention provides isolated BTL-II proteins, nucleic acids, antibodies, antagonists, and agonists and methods of making and using the same. Diagnostic, screening, and therapeutic methods using the compositions of the invention are provided. For example, the compositions of the invention can be used for diagnosis and treatment of inflammatory bowel diseases and for enhancing a mucosal immune response to an antigen.
摘要翻译: 本发明提供了分离的BTL-II蛋白,核酸,抗体,拮抗剂和激动剂以及制备和使用它们的方法。 提供使用本发明组合物的诊断,筛选和治疗方法。 例如,本发明的组合物可用于炎症性肠病的诊断和治疗以及增强对抗原的粘膜免疫应答。
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6.
公开(公告)号:US20130101590A1
公开(公告)日:2013-04-25
申请号:US13640232
申请日:2011-04-08
IPC分类号: A61K39/395 , C07K16/18
CPC分类号: A61K39/39533 , A61K38/00 , A61K39/00 , C07K14/435 , C07K14/70503 , C07K16/18 , C07K2317/52 , C07K2319/30 , C07K2319/32
摘要: The invention provides novel BTNL9 proteins, including multimers, fragments, and variants of a human BTNL9 protein. In addition, antibodies that can bind to BTNL9 proteins and nucleic acids encoding BTNL9 proteins are provided. Uses for BTNL9 proteins, and agonists or antagonists thereof, are described.
摘要翻译: 本发明提供新的BTNL9蛋白,包括人类BTNL9蛋白的多聚体,片段和变体。 此外,还提供可结合BTNL9蛋白的抗体和编码BTNL9蛋白的核酸。 描述了BTNL9蛋白质的用途及其激动剂或拮抗剂。
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