公开(公告)号：US20100093634A1

公开(公告)日：2010-04-15

申请号：US12576851

申请日：2009-10-09

申请人： Paul A. Welling ,  Liang Fang

发明人： Paul A. Welling ,  Liang Fang

IPC分类号： A61K38/16 ,  A61K38/02 ,  A61K31/7052 ,  A61P7/00 ,  C07K7/06

CPC分类号： A61K31/7052 ,  A61K38/00 ,  C07K7/06

摘要： The internalization sequence at the C-terminal end of the ROMK protein has been identified and sequenced. It has been discovered determined that endocytosis is triggered by binding of the ROMK internalization sequence to ARH protein, which is co-localized and expressed with ROMK. New methods of treating or preventing hyperkalemia have been discovered that include administering to a patient who is at risk of developing hyperkalemia or who has hyperkalemia, a therapeutically effective amount of an agent that blocks the interaction of the ROMK internalization sequence with ARH protein, thereby preventing or reducing ARH-induced endocytosis of ROMK.

摘要翻译： 已经鉴定并测序了ROMK蛋白C末端的内化序列。 已经发现确定内吞作用是通过将ROMK内化序列与ARH蛋白的结合引发的，所述ARH蛋白被共定位并用ROMK表达。 已经发现了治疗或预防高钾血症的新方法，其包括向有发展高钾血症或具有高钾血症风险的患者施用治疗有效量的阻断ROMK内化序列与ARH蛋白相互作用的试剂，由此预防 或减少ARH诱导的ROMK内吞作用。

公开(公告)号：US08288346B2

公开(公告)日：2012-10-16

申请号：US12576851

申请日：2009-10-09

申请人： Paul A. Welling ,  Liang Fang

发明人： Paul A. Welling ,  Liang Fang

IPC分类号： A61K38/16 ,  A61K38/00 ,  C07K14/435

CPC分类号： A61K31/7052 ,  A61K38/00 ,  C07K7/06

摘要： The internalization sequence at the C-terminal end of the ROMK protein has been identified and sequenced. It has been discovered determined that endocytosis is triggered by binding of the ROMK internalization sequence to ARH protein, which is co-localized and expressed with ROMK. New methods of treating or preventing hyperkalemia have been discovered that include administering to a patient who is at risk of developing hyperkalemia or who has hyperkalemia, a therapeutically effective amount of an agent that blocks the interaction of the ROMK internalization sequence with ARH protein, thereby preventing or reducing ARH-induced endocytosis of ROMK.

摘要翻译： 已经鉴定并测序了ROMK蛋白C末端的内化序列。 已经发现确定内吞作用是通过将ROMK内化序列与ARH蛋白的结合引发的，所述ARH蛋白被共定位并用ROMK表达。 已经发现了治疗或预防高钾血症的新方法，其包括向有发展高钾血症或具有高钾血症风险的患者施用治疗有效量的阻断ROMK内化序列与ARH蛋白相互作用的试剂，由此预防 或减少ARH诱导的ROMK内吞作用。