公开(公告)号：US20240082263A1

公开(公告)日：2024-03-14

申请号：US18144230

申请日：2023-05-07

Applicant: PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION

Inventor： Hyung-Sik KIM ,  Yoo Jin SEO ,  Ji-Su AHN

IPC: A61K31/559 ,  A61K31/165 ,  A61K31/4045 ,  A61K31/5575 ,  A61P1/00

CPC classification number: A61K31/559 ,  A61K31/165 ,  A61K31/4045 ,  A61K31/5575 ,  A61P1/00

Abstract: The present invention relates to a pharmaceutical composition for combined administration of melatonin and prostaglandin E2 (PGE2) for the treatment of intestinal epithelial injury diseases, and it is confirmed that when intestinal epithelial organoids are treated in combination with melatonin and PGE2, the expression of revival stem cell markers increases more than when the two substances are treated alone, and therefore it can be usefully used as a composition for preventing, treating or improving intestinal epithelial injury diseases.