公开(公告)号：US20140271783A1

公开(公告)日：2014-09-18

申请号：US14350749

申请日：2012-10-15

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Rodolfo Pinal ,  Bo Zhou ,  Andrew Otte

IPC: A61K9/70 ,  A61K9/00 ,  A61K31/343

CPC classification number: A61K9/7007 ,  A61K9/0056 ,  A61K9/4808 ,  A61K31/343 ,  B32B7/08 ,  B32B7/12 ,  B32B23/22 ,  B32B37/18 ,  B32B2317/18 ,  B32B2535/00

Abstract: A combination of sheets can be combined into an ingestible unit. The individual sheets can be prepared to have one or more functionalities, such as providing a biologically active agent, disintegrating and opening the unit, controlling release of an agent, facilitating absorption from the GI tract, as well as many others. The individual sheets can be selectively identified for combining into a multifunctional ingestible unit with a random or predetermined arrangement or stacking pattern. The individual sheets can be loose in a capsule or laminated together into a stacked layered structure. The combination of sheets can be pressed, laminated, tableted, or otherwise prepared into an ingestible unit. The ingestible unit can be predetermined to be useful for administering a drug, drug combination, multi-drug regimen as well as tailored to subject-specific multi-drug therapeutic regimens. The sheets can be loaded with any type of agent ranging from drugs to anti-counterfeit agents.

Abstract translation: 片材的组合可以组合成可摄入的单元。 单个片材可以被制备成具有一种或多种功能，例如提供生物活性剂，分解和打开单元，控制试剂的释放，促进胃肠道吸收以及许多其它功能。 可以选择性地识别各个片材，以组合成具有随机或预定布置或堆叠图案的多功能可摄取单元。 单个片材可以在胶囊中松动或层压在一起成堆叠的分层结构。 片材的组合可以被压制，层压，压片或以其它方式制备成可摄入的单元。 可摄入的单元可以被预定为可用于施用药物，药物组合，多药物方案以及针对受试者特异性多药物治疗方案。 纸张可以装载从药物到防伪剂的任何类型的药剂。

公开(公告)号：US20160346225A1

公开(公告)日：2016-12-01

申请号：US15232307

申请日：2016-08-09

Applicant: Purdue Research Foundation

Inventor： Rodolfo Pinal ,  Bo Zhou ,  Andrew Otte

IPC: A61K9/70 ,  B32B7/08 ,  B32B7/12 ,  B32B37/18 ,  B32B23/22

CPC classification number: A61K9/7007 ,  A61K9/0056 ,  A61K9/4808 ,  A61K31/343 ,  B32B7/08 ,  B32B7/12 ,  B32B23/22 ,  B32B37/18 ,  B32B2317/18 ,  B32B2535/00

Abstract: A combination of sheets can be combined into an ingestible unit. The individual sheets can be prepared to have one or more functionalities, such as providing a biologically active agent, disintegrating and opening the unit, controlling release of an agent, facilitating absorption from the GI tract, as well as many others. The individual sheets can be selectively identified for combining into a multifunctional ingestible unit with a random or predetermined arrangement or stacking pattern. The individual sheets can be loose in a capsule or laminated together into a stacked layered structure. The combination of sheets can be pressed, laminated, tableted, or otherwise prepared into an ingestible unit. The ingestible unit can be predetermined to be useful for administering a drug, drug combination, multi-drug regimen as well as tailored to subject-specific multi-drug therapeutic regimens. The sheets can be loaded with any type of agent ranging from drugs to anti-counterfeit agents.

Abstract translation: 片材的组合可以组合成可摄入的单元。 单个片材可以被制备成具有一种或多种功能，例如提供生物活性剂，分解和打开单元，控制试剂的释放，促进胃肠道吸收以及许多其它功能。 可以选择性地识别各个片材，以组合成具有随机或预定布置或堆叠图案的多功能可摄取单元。 单个片材可以在胶囊中松动或层压在一起成堆叠的分层结构。 片材的组合可以被压制，层压，压片或以其它方式制备成可摄入的单元。 可摄入的单元可以被预定为可用于施用药物，药物组合，多药物方案以及针对受试者特异性多药物治疗方案。 纸张可以装载从药物到防伪剂的任何类型的药剂。

公开(公告)号：US20190201351A1

公开(公告)日：2019-07-04

申请号：US16293565

申请日：2019-03-05

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： Rodolfo Pinal ,  Bo Zhou ,  Andrew Otte

IPC: A61K9/70 ,  B32B7/12 ,  A61K31/343 ,  B32B7/08 ,  B32B37/18 ,  B32B23/22 ,  A61K9/00

CPC classification number: A61K9/7007 ,  A61K9/0056 ,  A61K9/4808 ,  A61K31/343 ,  B32B7/08 ,  B32B7/12 ,  B32B23/22 ,  B32B37/18 ,  B32B2317/18 ,  B32B2535/00

Abstract: A combination of sheets can be combined into an ingestible unit. The individual sheets can be prepared to have one or more functionalities, such as providing a biologically active agent, disintegrating and opening the unit, controlling release of an agent, facilitating absorption from the GI tract, as well as many others. The individual sheets can be selectively identified for combining into a multifunctional ingestible unit with a random or predetermined arrangement or stacking pattern. The individual sheets can be loose in a capsule or laminated together into a stacked layered structure. The combination of sheets can be pressed, laminated, tableted, or otherwise prepared into an ingestible unit. The ingestible unit can be predetermined to be useful for administering a drug, drug combination, multi-drug regimen as well as tailored to subject-specific multi-drug therapeutic regimens. The sheets can be loaded with any type of agent ranging from drugs to anti-counterfeit agents.