公开(公告)号：US10213111B2

公开(公告)日：2019-02-26

申请号：US14766445

申请日：2014-02-14

申请人： BC Cancer, part of the Provincial Health Services Authority

发明人： Haishan Zeng ,  Jianhua Zhao ,  Michael Short ,  Thomas Andrew Braun

IPC分类号： A61B5/00 ,  G01J3/10 ,  G01J3/44 ,  F21K9/60

摘要： Examples of a spectroscopy system with a specially design ambient illumination system are disclosed. The ambient illumination system comprises one or more light emitting diodes (LEDs) that provide illumination light in the wavelength of 400-785 nm. The ambient illumination system can further comprise a filter to block light above 785 nm. The filter can be placed directly in front of LED emitters. The LEDs can be white LEDs or RGB LEDs. The spectroscopy system can further comprise a control system that can receive a signal from the spectral probe when the spectral measurements commence and can instantaneously send a signal to automatically switch off the ambient illumination system and to receive a signal from the spectral probe when the spectral measurements are terminated and automatically switch on the ambient illumination system. Examples of methods of operating the spectroscopy system and the ambient illumination system are disclosed.

公开(公告)号：US11555742B2

公开(公告)日：2023-01-17

申请号：US17271826

申请日：2019-09-04

申请人： PROVINCIAL HEALTH SERVICES AUTHORITY

发明人： Zhenguo Wu ,  Haishan Zeng ,  Jianhua Zhao ,  Liwei Jiang

IPC分类号： G01J3/44 ,  G01J3/02 ,  G01J3/06 ,  G01J3/10

摘要： Systems for confocal Raman spectroscopy of points of interest or regions of interest with concurrent imaging are disclosed. The imaging may be used for real time selection of points of interest or regions of interest for Raman spectroscopy and to monitor for unwanted motions of a sample while Raman spectra are acquired. Disclosed embodiments apply Reflectance confocal microscopy (RCM) in a confocal Raman spectroscopy system. A single laser may be used as a light source for both RCM and micro-Raman spectroscopy. A Faraday optical isolator may be applied to extract RCM signals for imaging Systems as described herein have example application for ex vivo sample and in vivo skin measurement.

公开(公告)号：US11660378B2

公开(公告)日：2023-05-30

申请号：US16958062

申请日：2019-01-25

申请人： PROVINCIAL HEALTH SERVICES AUTHORITY

发明人： Hanna Claire Mcgregor ,  Michael Short ,  Haishan Zeng

IPC分类号： A61B1/00 ,  A61B1/07 ,  A61B1/267 ,  A61B5/00 ,  A61B1/005 ,  A61L29/04

CPC分类号： A61L29/041 ,  A61B1/005 ,  A61B1/0011 ,  A61B1/00117 ,  A61B1/00126 ,  A61B1/07 ,  A61B1/2676 ,  A61B5/0075 ,  A61B1/00165

摘要： A Raman endoscope for use in obtaining in vivo Raman spectra in the peripheral airways of the lungs and a method of constructing the Raman endoscope are disclosed. The endoscope has a tubular sheath containing a fiber bundle. The sheath has an outer diameter of less than 1.35 mm. The sheath is made of fluorinated ethylene propylene. The sheath is flexible along its length from a first end to a point along the sheath so that it can navigate sharp turns within the peripheral airways. A layer of coating covers the sheath along a terminal length and a probe tip of the fiber bundle. The terminal length extends along a length of the sheath extending from a second end opposite to the first end to the point. Terminal length is rigid to facilitate advancement of the endoscope towards the lesion of interest. Terminal length is 5 mm or less.