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1.发明公开公开(公告)号：US20240319169A1
公开(公告)日：2024-09-26
申请号：US18271773
申请日：2021-01-22
发明人： Qingsong LIU , Feiyang LIU , Xiaoyu LI , Husheng MEI , Wenchao WANG , Tao REN , Li WANG
CPC分类号： G01N33/5011 , C12N5/0693 , C12N2501/115 , C12N2501/119 , C12N2501/125 , C12N2501/135 , C12N2501/345 , C12N2533/54
摘要： The present invention provides a cell culture medium for culturing primary gastrointestinal stromal tumor cells, comprising gastrin, N2, insulin, a receptor tyrosine kinase ligand, and a Rock kinase inhibitor. The present invention further provides a method for culturing gastrointestinal stromal tumor cells by using the cell culture medium, and an application and a method of an expanded cell population, which is obtained by using the method, in efficacy evaluation or screening.
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公开(公告)号：US20190084960A1
公开(公告)日：2019-03-21
申请号：US16089547
申请日：2017-03-28
发明人： Qingsong LIU , Jing LIU , Qiang WANG , Beilei WANG , Feiyang LIU , Shuang QI , Ziping QI , Fengming ZOU , Cheng CHEN , Wenchao WANG , Chen HU , Xiaochuan LIU , Wei WANG , Aoli WANG , Li WANG , Zhenquan HU , Tao REN
IPC分类号： C07D401/06 , A61K31/4545 , C07D211/44 , A61K31/445 , C07D413/06 , A61K31/454 , C07D401/14 , C07D409/14 , A61P35/00
摘要： The present invention provides a compound represented by formula (I), or a pharmaceutically acceptable salt, a solvate, an ester, an acid, a metabolite or a prodrug thereof. The compound itself in the present invention or in combination with at least one therapeutic agent can be used for preventing or treating diseases, disorders or symptoms caused by the adjustment of the activity of tyrosine kinase C-KIT, or affected by the activity of the tyrosine kinase C-KIT or involving in the activity of the tyrosine kinase C-KIT, especially cancers or other cell proliferation diseases.
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公开(公告)号：US20220389379A1
公开(公告)日：2022-12-08
申请号：US17775106
申请日：2019-11-18
发明人： Qingsong LIU , Feiyang LIU , Husheng MEI , Wenchao WANG , Ming ZHAO , Zongru JIANG , Tao REN , Li WANG
摘要： Provided is a culture medium containing amphiregulin for culturing primary breast epithelial cells and a culture method involving using the medium. In the culturing method, primary cells are cultured on a culture vessel coated with an extracellular matrix gel by using the culture medium, and the primary cells grow on the culture vessel, which has been coated with the extracellular matrix gel, and proliferate rapidly under the combined action of nutrient factors and an extracellular matrix contained in the primary cell culture medium. The cell model obtained by the primary cell culture medium and the primary cell culture method can be used for the evaluating the efficacy of and screening drugs.
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