公开(公告)号：US11660342B2

公开(公告)日：2023-05-30

申请号：US17198419

申请日：2021-03-11

Applicant: POSTECH Research and Business Development Foundation

Inventor： Won Jong Kim ,  Taejeong Kim

IPC: A61K41/00 ,  A61K33/24 ,  A61K38/06 ,  A61P25/16 ,  A61P25/28 ,  A61K9/51

CPC classification number: A61K41/0028 ,  A61K9/5138 ,  A61K33/24 ,  A61K38/063 ,  A61P25/16 ,  A61P25/28

Abstract: The present invention relates to a method for increasing the blood-brain barrier permeability, and more particularly, to a method for increasing the blood-brain barrier permeability, the method including: (S1) a step of delivering a nanogenerator carrying a nitric oxide (NO) donor to a site adjacent to the blood-brain barrier; (S2) a step of delivering a first triggering stimulus to an area where the nanogenerator has been delivered so as to release nitric oxide from the nanogenerator; and (S3) a step of allowing the released nitric oxide to activate matrix metallopeptidase-9 (MMP-9) and inducing the activated MMP-9 to weaken the tight junction between a cerebrovascular endothelial cell and another cerebrovascular endothelial cell.

公开(公告)号：US20210290762A1

公开(公告)日：2021-09-23

申请号：US17198419

申请日：2021-03-11

Applicant: POSTECH Research and Business Development Foundation

Inventor： Won Jong KIM ,  Taejeong Kim

IPC: A61K41/00 ,  A61K33/24 ,  A61K38/06 ,  A61P25/16 ,  A61P25/28 ,  A61K9/51

Abstract: The present invention relates to a method for increasing the blood-brain barrier permeability, and more particularly, to a method for increasing the blood-brain barrier permeability, the method including: (S1) a step of delivering a nanogenerator carrying a nitric oxide (NO) donor to a site adjacent to the blood-brain barrier; (S2) a step of delivering a first triggering stimulus to an area where the nanogenerator has been delivered so as to release nitric oxide from the nanogenerator; and (S3) a step of allowing the released nitric oxide to activate matrix metallopeptidase-9 (MMP-9) and inducing the activated MMP-9 to weaken the tight junction between a cerebrovascular endothelial cell and another cerebrovascular endothelial cell.

公开(公告)号：US20210244750A1

公开(公告)日：2021-08-12

申请号：US17165130

申请日：2021-02-02

Applicant: POSTECH Research and Business Development Foundation

Inventor： Won Jong Kim ,  Taejeong Kim

IPC: A61K31/655 ,  A61K49/00

Abstract: The present invention relates to a composition to be used for increasing the blood-brain barrier permeability, the composition including a nitric oxide donor, and a use of the composition. More particularly, the invention relates to a composition to be used for increasing the blood-brain barrier permeability, the composition including a nitric oxide donor capable of carrying nitric oxide (NO), wherein the nitric oxide delivered to a site adjacent to the blood-brain barrier by the nitric oxide donor activates matrix metallopeptidase-9 (MMP-9), and the activated MMP-9 weakens a tight junction between a cerebrovascular endothelial cell and a cerebrovascular endothelial cell to increase the blood-brain barrier permeability, and to a use of the composition.