公开(公告)号：US12018111B2

公开(公告)日：2024-06-25

申请号：US17694883

申请日：2022-03-15

申请人： POSTECH Research and Business Development Foundation

发明人： Jin Kon Kim ,  Seonghyeon Ahn

IPC分类号： C08F293/00 ,  A61K9/107 ,  B01J13/08 ,  B01J31/06 ,  B01J35/23 ,  B01J37/00 ,  B01J37/04 ,  C08J5/18

CPC分类号： C08F293/00 ,  A61K9/1075 ,  B01J13/08 ,  B01J31/063 ,  B01J35/23 ,  B01J37/0072 ,  B01J37/04 ,  C08J5/18 ,  B01J2231/005 ,  C08J2353/02

摘要： Proposed are a core-satellite micelle containing a tetra-block copolymer and a preparation method thereof. The core-satellite micelle includes a core, a shell surrounding the core, and a plurality of satellite domains positioned inside the shell. The core-satellite micelle contains a tetra-block copolymer represented by Structural Formula 1 below. The shell includes a first-monomer first block A1 and a first-monomer second block A2, and the satellite domain includes a second-monomer first block B1 and a second-monomer second block B2. The core-satellite micelle is foiled through self-assembly of the tetra-block copolymer, thereby having a larger interfacial contact area than existing block-copolymer micelles. Therefore, the core-satellite micelle can be used in next-generation nanotechnology applications such as drug delivery systems, porous catalyst materials, and sensors.

A1-B1-A2-B2  [Structural Formula 1]

In Structural Formula 1,



A1 is a first-monomer first block,
B1 is a second-monomer first block,
A2 is a first-monomer second block, and
B2 is a second-monomer second block.

公开(公告)号：US20220298284A1

公开(公告)日：2022-09-22

申请号：US17694883

申请日：2022-03-15

申请人： POSTECH Research and Business Development Foundation

发明人： Jin Kon KIM ,  Seonghyeon Ahn

IPC分类号： C08F293/00 ,  C08J5/18 ,  B01J13/08 ,  B01J31/06 ,  B01J37/04 ,  B01J37/00 ,  B01J35/00 ,  A61K9/107

摘要： Proposed are a core-satellite micelle containing a tetra-block copolymer and a preparation method thereof. The core-satellite micelle includes a core, a shell surrounding the core, and a plurality of satellite domains positioned inside the shell. The core-satellite micelle contains a tetra-block copolymer represented by Structural Formula 1 below. The shell includes a first-monomer first block A1 and a first-monomer second block A2, and the satellite domain includes a second-monomer first block B1 and a second-monomer second block B2. The core-satellite micelle is foiled through self-assembly of the tetra-block copolymer, thereby having a larger interfacial contact area than existing block-copolymer micelles. Therefore, the core-satellite micelle can be used in next-generation nanotechnology applications such as drug delivery systems, porous catalyst materials, and sensors. A1-B1-A2-B2   [Structural Formula 1] In Structural Formula 1, A1 is a first-monomer first block, B1 is a second-monomer first block, A2 is a first-monomer second block, and B2 is a second-monomer second block.