公开(公告)号：US12110539B2

公开(公告)日：2024-10-08

申请号：US17675229

申请日：2022-02-18

Applicant: POSTECH Research and Business Development Foundation

Inventor： Seung Soo Oh ,  Hye Bin Yoo

IPC: C12Q1/6823 ,  C12Q1/6853 ,  C12Q1/686

CPC classification number: C12Q1/6823 ,  C12Q1/6853 ,  C12Q1/686

Abstract: The present invention relates to a metal ion-start DNA polymerase switch, a composition for isothermal polymerase amplification containing the same, and an isothermal amplification method using the metal ion-start DNA polymerase switch. The metal ion-start DNA polymerase switch according to the present invention may comprise: a binding module composed of TQ30 aptamer; a locking or unlocking module; and a catalytic module connecting between the binding module and the locking or unlocking module and composed of DNAzyme.

公开(公告)号：US20230074735A1

公开(公告)日：2023-03-09

申请号：US17675229

申请日：2022-02-18

Applicant: POSTECH Research and Business Development Foundation

Inventor： Seung Soo OH ,  Hye Bin Yoo

IPC: C12Q1/6823 ,  C12Q1/6853 ,  C12Q1/686

Abstract: The present invention relates to a metal ion-start DNA polymerase switch, a composition for isothermal polymerase amplification containing the same, and an isothermal amplification method using the metal ion-start DNA polymerase switch. The metal ion-start DNA polymerase switch according to the present invention may comprise: a binding module composed of TQ30 aptamer; a locking or unlocking module; and a catalytic module connecting between the binding module and the locking or unlocking module and composed of DNAzyme.