公开(公告)号：US20210290762A1

公开(公告)日：2021-09-23

申请号：US17198419

申请日：2021-03-11

Applicant: POSTECH Research and Business Development Foundation

Inventor： Won Jong KIM ,  Taejeong Kim

IPC: A61K41/00 ,  A61K33/24 ,  A61K38/06 ,  A61P25/16 ,  A61P25/28 ,  A61K9/51

Abstract: The present invention relates to a method for increasing the blood-brain barrier permeability, and more particularly, to a method for increasing the blood-brain barrier permeability, the method including: (S1) a step of delivering a nanogenerator carrying a nitric oxide (NO) donor to a site adjacent to the blood-brain barrier; (S2) a step of delivering a first triggering stimulus to an area where the nanogenerator has been delivered so as to release nitric oxide from the nanogenerator; and (S3) a step of allowing the released nitric oxide to activate matrix metallopeptidase-9 (MMP-9) and inducing the activated MMP-9 to weaken the tight junction between a cerebrovascular endothelial cell and another cerebrovascular endothelial cell.

公开(公告)号：US20240301431A1

公开(公告)日：2024-09-12

申请号：US18020145

申请日：2021-10-05

Applicant: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION

Inventor： Won Jong KIM ,  Jin Seong KIM ,  Hyeong Mok PARK

IPC: C12N15/115 ,  A61K9/51 ,  A61K47/69 ,  A61P27/02

CPC classification number: C12N15/115 ,  A61K9/513 ,  A61K47/6923 ,  A61K47/6929 ,  A61P27/02 ,  C12N2310/16

Abstract: The present disclosure relates to a polymer-coated gold nanoparticle-aptamer nanoconstruct having reactive oxygen species sensitivity and capable of treating inflammatory diseases through reactive oxygen species scavenge and TNF-α capture.

公开(公告)号：US20240165128A1

公开(公告)日：2024-05-23

申请号：US18277652

申请日：2022-01-10

Applicant: POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION ,  OMNIAMED CO. LTD

Inventor： Won Jong KIM ,  Tae Jeong KIM

IPC: A61K31/573 ,  A61K9/00 ,  A61K9/06 ,  A61K45/06 ,  A61P19/02

CPC classification number: A61K31/573 ,  A61K9/0019 ,  A61K9/06 ,  A61K45/06 ,  A61P19/02

Abstract: The present disclosure relates to a nitric oxide-sensitive hydrogel. The hydrogel is formed through in-situ hybridization in a target site by means of a click chemical reaction and is prepared using a nitric oxide-sensitive crosslinker. The hydrogel can effectively collect and scavenge nitric oxide overexpressed in the target site, and a drug loaded in the hydrogel can be locally and sensitively released to a target site to be treated. Therefore, the hydrogel can be effectively used to prevent and treat inflammatory disease caused by the overexpression of nitric oxide.