公开(公告)号：US10292960B2

公开(公告)日：2019-05-21

申请号：US15878057

申请日：2018-01-23

申请人： PITNEY PHARMACEUTICALS PTY LIMITED

发明人： Nobuharu Andoh ,  Osamu Sanpei ,  Tetsuo Toga ,  David Morris ,  Roger Aston ,  Koji Tanaka ,  Tomokazu Hino

IPC分类号： A61K31/277 ,  A61K31/341 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/381 ,  A61K31/415 ,  A61K31/4196 ,  A61K31/42 ,  A61K31/421 ,  A61K31/426 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4965 ,  A61K31/465 ,  A61K31/505

摘要： The present invention relates to an anticancer agent having a high safety and a superior anticancer activity, and an anticancer agent containing, as an active ingredient, an aminoacetonitrile compound represented by the formula (I) wherein R1 is a hydrogen atom, an alkyl group and the like, R2, R3, and R4 are the same or different and each is a hydrogen atom, an alkyl group and the like, R5 and R6 are the same or different and each is a hydrogen atom, a halogen atom and the like, m is 0 or 1, R is a halogen atom, a cyano group, a nitro group, a phenyl group optionally substituted by an alkyl group and the like, an alkyl group and the like, Ar1 is a phenyl group, a naphthyl group, a pyridyl group, a pyrazolyl group, or the like, each of which is optionally substituted by a halogen atom, a cyano group, a nitro group, alkyl group and the like, and W is —O—, —S—, —SO2—, or —N(R7)— wherein R7 is a hydrogen atom, a (C1-C6) alkyl group and the like, or a pharmacologically acceptable salt thereof.

公开(公告)号：US10391076B2

公开(公告)日：2019-08-27

申请号：US15552907

申请日：2016-02-24

申请人： Pitney Pharmaceuticals Pty Limited

发明人： Nobuharu Andoh ,  Osamu Sanpei ,  Tetsuo Toga ,  David Lawson Morris ,  Roger Aston ,  Koji Tanaka ,  Tomokazu Hino

IPC分类号： A61K31/277 ,  A61K31/433 ,  A61K31/4245 ,  A61K31/5383 ,  A61K31/4196 ,  A61K31/437 ,  A61K31/381 ,  A61P35/00 ,  A61K31/40 ,  A61K31/415 ,  A61K31/4192 ,  A61K31/42 ,  A61K31/425 ,  A61K31/44 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/496 ,  A61K31/4965 ,  A61K31/505 ,  A61K31/535

摘要： The present invention relates to an anticancer agent having a high safety and a superior anticancer activity, and anticancer agent containing, as an active ingredient, an aminoacetonitrile compound represented by the formula (I) wherein R1 is a hydrogen atom, an alkyl group and the like, R2, R3, and R4 are the same or different and each is a hydrogen atom, an alkyl group and the like, R5 and R6 are the same or different and each is a hydrogen atom, a halogen atom and the like, m is 0 or 1, R is a halogen atom, a cyano group, a nitro group, a phenyl group optionally substituted by an alkyl group and the like, an alkyl group and the like, Ar1 is a phenyl group, a naphthyl group, a pyridyl group, a pyrazolyl group, or the like, each of which is optionally substituted by a halogen atom, a cyano group, a nitro group, alkyl group and the like, and W is —O—, —S—, —SO2—, or —N(R7)— wherein R7 is a hydrogen atom, a (C1-C6)alkyl group and the like, or a pharmacologically acceptable salt thereof.

公开(公告)号：US09907778B2

公开(公告)日：2018-03-06

申请号：US14917724

申请日：2014-09-12

申请人： PITNEY PHARMACEUTICALS PTY LIMITED

发明人： Nobuharu Andoh ,  Osamu Sanpei ,  Tetsuo Toga ,  David Lawson Morris ,  Roger Aston ,  Koji Tanaka ,  Tomokazu Hino

IPC分类号： A61K31/341 ,  A61K31/4245 ,  A61K31/5383 ,  A61K31/4196 ,  A61K31/437 ,  A61K31/381 ,  A61K31/5377 ,  A61K31/415 ,  A61K31/277 ,  A61K31/42 ,  A61K31/421 ,  A61K31/426 ,  A61K31/433 ,  A61K31/44 ,  A61K31/4965 ,  A61K31/505

CPC分类号： A61K31/277 ,  A61K31/341 ,  A61K31/381 ,  A61K31/415 ,  A61K31/4196 ,  A61K31/42 ,  A61K31/421 ,  A61K31/4245 ,  A61K31/426 ,  A61K31/433 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4965 ,  A61K31/505 ,  A61K31/5377 ,  A61K31/5383

摘要： The present invention relates to an anticancer agent having a high safety and a superior anticancer activity, and an anticancer agent containing, as an active ingredient, an aminoacetonitrile compound represented by the formula (I) wherein R1 is a hydrogen atom, an alkyl group and the like, R2, R3, and R4 are the same or different and each is a hydrogen atom, an alkyl group and the like, R5 and R6 are the same or different and each is a hydrogen atom, a halogen atom and the like, m is 0 or 1, R is a halogen atom, a cyano group, a nitro group, a phenyl group optionally substituted by an alkyl group and the like, an alkyl group and the like, Ar1 is a phenyl group, a naphthyl group, a pyridyl group, a pyrazolyl group, or the like, each of which is optionally substituted by a halogen atom, a cyano group, a nitro group, alkyl group and the like, and W is —O—, —S—, —SO2—, or —N(R7)— wherein R7 is a hydrogen atom, a (C1-C6)alkyl group and the like, or a pharmacologically acceptable salt thereof.