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公开(公告)号：US20150051290A1
公开(公告)日：2015-02-19
申请号：US14387270
申请日：2013-03-22
发明人： David Lawson Morris
IPC分类号： A61K31/277
CPC分类号： A61K31/277 , A61K31/275 , C07C255/29 , C07C317/44 , C07C323/62
摘要： The present invention relates to kinase inhibitors for the treatment of cancer. Specifically, the present invention relates to the use of aminoactonitrile derivatives (AADs) in the treatment of cancer.
摘要翻译： 本发明涉及用于治疗癌症的激酶抑制剂。 具体地说，本发明涉及氨基糖衍生物（AADs）在癌症治疗中的应用。
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公开(公告)号：US20160228399A1
公开(公告)日：2016-08-11
申请号：US15021217
申请日：2014-10-31
IPC分类号： A61K31/277 , A61K31/513 , A61K31/7068 , A61K31/65 , A61K31/337 , A61K31/4184 , A61K31/429 , A61K31/17 , A61K31/5415 , A61K31/4965 , A61K31/167 , A61K31/4045 , A61K31/138 , A61K31/585 , A61K31/5513 , A61K31/567 , A61K31/40 , A61K31/704
CPC分类号： A61K31/277 , A61K31/138 , A61K31/167 , A61K31/17 , A61K31/275 , A61K31/337 , A61K31/40 , A61K31/4045 , A61K31/4184 , A61K31/429 , A61K31/4965 , A61K31/513 , A61K31/5415 , A61K31/5513 , A61K31/567 , A61K31/585 , A61K31/65 , A61K31/704 , A61K31/7068 , C07C255/29 , C07C317/44 , C07C323/62 , A61K2300/00
摘要： The present invention relates to pharmaceutical combinations comprising aminoacetonitrile derivatives and anticancer compounds. Further, the present invention relates to these pharmaceutical combinations for use in the treatment of cancer.
摘要翻译： 本发明涉及包含氨基乙腈衍生物和抗癌化合物的药物组合。 此外，本发明涉及用于治疗癌症的这些药物组合。
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公开(公告)号：US20160220527A1
公开(公告)日：2016-08-04
申请号：US15057628
申请日：2016-03-01
发明人： David Lawson Morris
IPC分类号： A61K31/277
CPC分类号： A61K31/277 , A61K31/275 , C07C255/29 , C07C317/44 , C07C323/62
摘要： The present invention relates to kinase inhibitors for the treatment of cancer. Specifically, the present invention relates to the use of aminoactonitrile derivatives (AADs) in the treatment of cancer.
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公开(公告)号：US09833431B2
公开(公告)日：2017-12-05
申请号：US15021217
申请日：2014-10-31
IPC分类号： A01N47/10 , A61K31/34 , A61K31/277 , A61K31/337 , A61K31/513 , A61K31/65 , A61K31/704 , A61K31/7068 , A61K31/138 , A61K31/167 , A61K31/17 , A61K31/40 , A61K31/4045 , A61K31/4184 , A61K31/429 , A61K31/4965 , A61K31/5415 , A61K31/5513 , A61K31/567 , A61K31/585 , A61K31/275 , C07C255/29 , C07C323/62 , C07C317/44
CPC分类号： A61K31/277 , A61K31/138 , A61K31/167 , A61K31/17 , A61K31/275 , A61K31/337 , A61K31/40 , A61K31/4045 , A61K31/4184 , A61K31/429 , A61K31/4965 , A61K31/513 , A61K31/5415 , A61K31/5513 , A61K31/567 , A61K31/585 , A61K31/65 , A61K31/704 , A61K31/7068 , C07C255/29 , C07C317/44 , C07C323/62 , A61K2300/00
摘要： The present invention relates to pharmaceutical combinations comprising aminoacetonitrile derivatives and anticancer compounds. Further, the present invention relates to these pharmaceutical combinations for use in the treatment of cancer.
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公开(公告)号：US10391076B2
公开(公告)日：2019-08-27
申请号：US15552907
申请日：2016-02-24
发明人： Nobuharu Andoh , Osamu Sanpei , Tetsuo Toga , David Lawson Morris , Roger Aston , Koji Tanaka , Tomokazu Hino
IPC分类号： A61K31/277 , A61K31/433 , A61K31/4245 , A61K31/5383 , A61K31/4196 , A61K31/437 , A61K31/381 , A61P35/00 , A61K31/40 , A61K31/415 , A61K31/4192 , A61K31/42 , A61K31/425 , A61K31/44 , A61K31/4433 , A61K31/4436 , A61K31/496 , A61K31/4965 , A61K31/505 , A61K31/535
摘要： The present invention relates to an anticancer agent having a high safety and a superior anticancer activity, and anticancer agent containing, as an active ingredient, an aminoacetonitrile compound represented by the formula (I) wherein R1 is a hydrogen atom, an alkyl group and the like, R2, R3, and R4 are the same or different and each is a hydrogen atom, an alkyl group and the like, R5 and R6 are the same or different and each is a hydrogen atom, a halogen atom and the like, m is 0 or 1, R is a halogen atom, a cyano group, a nitro group, a phenyl group optionally substituted by an alkyl group and the like, an alkyl group and the like, Ar1 is a phenyl group, a naphthyl group, a pyridyl group, a pyrazolyl group, or the like, each of which is optionally substituted by a halogen atom, a cyano group, a nitro group, alkyl group and the like, and W is —O—, —S—, —SO2—, or —N(R7)— wherein R7 is a hydrogen atom, a (C1-C6)alkyl group and the like, or a pharmacologically acceptable salt thereof.
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公开(公告)号：US09907778B2
公开(公告)日：2018-03-06
申请号：US14917724
申请日：2014-09-12
发明人： Nobuharu Andoh , Osamu Sanpei , Tetsuo Toga , David Lawson Morris , Roger Aston , Koji Tanaka , Tomokazu Hino
IPC分类号： A61K31/341 , A61K31/4245 , A61K31/5383 , A61K31/4196 , A61K31/437 , A61K31/381 , A61K31/5377 , A61K31/415 , A61K31/277 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/433 , A61K31/44 , A61K31/4965 , A61K31/505
CPC分类号： A61K31/277 , A61K31/341 , A61K31/381 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/433 , A61K31/437 , A61K31/44 , A61K31/4965 , A61K31/505 , A61K31/5377 , A61K31/5383
摘要： The present invention relates to an anticancer agent having a high safety and a superior anticancer activity, and an anticancer agent containing, as an active ingredient, an aminoacetonitrile compound represented by the formula (I) wherein R1 is a hydrogen atom, an alkyl group and the like, R2, R3, and R4 are the same or different and each is a hydrogen atom, an alkyl group and the like, R5 and R6 are the same or different and each is a hydrogen atom, a halogen atom and the like, m is 0 or 1, R is a halogen atom, a cyano group, a nitro group, a phenyl group optionally substituted by an alkyl group and the like, an alkyl group and the like, Ar1 is a phenyl group, a naphthyl group, a pyridyl group, a pyrazolyl group, or the like, each of which is optionally substituted by a halogen atom, a cyano group, a nitro group, alkyl group and the like, and W is —O—, —S—, —SO2—, or —N(R7)— wherein R7 is a hydrogen atom, a (C1-C6)alkyl group and the like, or a pharmacologically acceptable salt thereof.
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公开(公告)号：US09308193B2
公开(公告)日：2016-04-12
申请号：US14387270
申请日：2013-03-22
发明人： David Lawson Morris
IPC分类号： A61K31/165 , C07C233/00 , A61K31/277 , C07C255/29 , A61K31/275 , C07C317/44 , C07C323/62
CPC分类号： A61K31/277 , A61K31/275 , C07C255/29 , C07C317/44 , C07C323/62
摘要： The present invention relates to kinase inhibitors for the treatment of cancer. Specifically, the present invention relates to the use of aminoactonitrile derivatives (AADs) in the treatment of cancer.
摘要翻译： 本发明涉及用于治疗癌症的激酶抑制剂。 具体而言，本发明涉及氨基糖衍生物（AAD）在癌症治疗中的应用。
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