公开(公告)号：US09644028B2

公开(公告)日：2017-05-09

申请号：US14768151

申请日：2014-02-14

申请人： PERSEUS PROTEOMICS INC.

发明人： Keisuke Ishii ,  Katsuyuki Mitomo ,  Katsushi Kouda ,  Fumiko Nomura ,  Yoko Kayukawa ,  Tadashi Matsuura

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61K47/48

CPC分类号： C07K16/28 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6889 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565

摘要： The present invention provides an anti-CDH3 humanized antibody having lower immunogenicity, and an anti-CDH3 humanized antibody drug conjugate having the aforementioned anti-CDH3 humanized antibody. The present invention provides a conjugate of an anti-CDH3 humanized antibody and a drug by conjugating a drug having cytotoxicity to an anti-CDH3 humanized antibody having complementarity determining region sequences derived from the heavy chain variable region of an antibody produced by cells having Accession No. NITE BP-1536, and complementarity determining region sequences derived from the light chain variable region thereof, and which also comprises a heavy chain human subgroup III consensus framework sequence or a human germline sequence selected under optimal alignment as a framework region sequence of the heavy chain variable region, and a light chain human κ subgroup I consensus framework sequence or a human germline sequence selected under optimal alignment as a framework region sequence of the light chain variable region.