公开(公告)号：US20140314992A1

公开(公告)日：2014-10-23

申请号：US14256674

申请日：2014-04-18

Applicant: ADVANCED BIO PROSTHETIC SURFACES, LTD., a wholly owned subsidiary of Palmaz Scientific, Inc.

Inventor： Julio C. PALMAZ ,  Eugene A. SPRAGUE

IPC: A61L31/02

CPC classification number: A61L31/028 ,  A61F2/00 ,  A61F2/0077 ,  A61F2/02 ,  A61F2002/0086 ,  A61F2310/00616 ,  A61L31/022 ,  A61L31/024 ,  Y10T428/24355

Abstract: Implantable materials having defined patterns of affinity regions for binding endothelial cells and providing for directed endothelial cell migration across the surface of the material. The affinity regions include photochemically altered regions of a material surface and physical members patterned on the material surface that exhibit a greater affinity for endothelial cell binding and migration than the remaining regions of the material surface.

Abstract translation: 可植入材料具有限定的内皮细胞结合亲和区域的图案，并提供穿过该材料表面的定向内皮细胞迁移。 亲和性区域包括材料表面的光化学改变的区域和在材料表面上图案化的物理构件，其对于内皮细胞结合和迁移显示出比材料表面的剩余区域更大的亲和力。

公开(公告)号：US20140296965A1

公开(公告)日：2014-10-02

申请号：US14213974

申请日：2014-03-14

Applicant: PALMAZ SCIENTIFIC, INC.

Inventor： Michael Poor ,  Armando GARZA ,  Scott CARPENTER ,  Julio C. PALMAZ

IPC: A61F2/91 ,  C25F3/14

CPC classification number: A61F2/91 ,  A61F2/915 ,  A61F2002/068 ,  A61F2002/823 ,  A61F2002/91575

Abstract: The monolithic device comprises a plurality of scaffolding members and a mesh patterned members webbed between the scaffolding members; the mesh patterned member webbed between the scaffolding members surround a lumen and generally expands from a contracted state to an expanded state; and mesh patterned members including a plurality of openings traversing the thickness of the mesh patterned member, and the mesh patterned members including a surface on which a pattern of openings is formed.

Abstract translation: 单片装置包括多个脚手架构件和在脚手架构件之间的网状图案构件; 脚手架构件之间的网状图案构件围绕着内腔并且通常从收缩状态扩展到扩张状态; 以及网格图案的构件，包括穿过所述网状图案构件的厚度的多个开口，并且所述网格图案构件包括其上形成有开口图案的表面。

公开(公告)号：US20130287931A1

公开(公告)日：2013-10-31

申请号：US13847996

申请日：2013-03-20

Applicant: Advanced Bio Prosthetic Surfaces, Ltd., a wholly owned subsidiary of Palmaz Scientific, Inc.

Inventor： Julio C. PALMAZ ,  Steven R. BAILEY ,  Christopher T. BOYLE ,  Christopher E. BANAS

IPC: C23C14/00 ,  C23C14/22 ,  C23C14/34 ,  C23C14/04

CPC classification number: C23C14/0005 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/072 ,  A61F2002/30322 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/9155 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2002/91583 ,  A61F2210/0076 ,  A61F2220/0058 ,  A61F2250/0014 ,  A61F2250/0026 ,  C23C14/042 ,  C23C14/221 ,  C23C14/34

Abstract: The method of making devices is disclosed herein. More particularly, a method of manufacturing a device, comprises: vacuum depositing a device-forming metal onto an unpatterned, exterior surface of a generally cylindrical substrate to form a generally tubular, unpatterned crystalline metal film under at least one vacuum deposition process condition selected from at least one of chamber pressure, deposition pressure, and partial pressure of a process gas, said at least one process condition optimized to substantially eliminate formation of chemical and intra- and intergranular precipitates in the bulk material; and removing the deposited generally tubular, unpatterned crystalline metal film from the generally cylindrical substrate.

Abstract translation: 本文公开了制造装置的方法。 更具体地说，一种制造器件的方法包括：将真空沉积器件形成金属真空沉积在大致圆柱形衬底的未图案化的外表面上，以在至少一个真空沉积工艺条件下形成大致管状的未图案化的结晶金属膜，该真空沉积工艺条件选自 处理气体的室压力，沉积压力和分压中的至少一个，所述至少一个工艺条件被优化以基本上消除在散装材料中形成化学和晶间和晶间沉淀物; 以及从大致圆柱形的基底去除沉积的大致管状的未图案化的结晶金属膜。

公开(公告)号：US20160135943A1

公开(公告)日：2016-05-19

申请号：US14852371

申请日：2015-09-11

Applicant: Advanced Bio Prosthetic Surfaces, Ltd., a wholly owned subsidiary of Palmaz Scientific, Inc.

Inventor： Christopher E. Banas ,  Julio C. PALMAZ

IPC: A61F2/06 ,  A61L27/06

CPC classification number: A61F2/04 ,  A61F2/06 ,  A61F2/82 ,  A61L27/06 ,  A61L27/50 ,  A61L31/022 ,  A61L31/14 ,  C23C14/0005 ,  Y10T83/04

Abstract: Implantable medical grafts fabricated of metallic or pseudometallic films of biocompatible materials having a plurality of microperforations passing through the film in a pattern that imparts fabric-like qualities to the graft or permits the geometric deformation of the graft. The implantable graft is preferably fabricated by vacuum deposition of metallic and/or pseudometallic materials into either single or multi-layered structures with the plurality of microperforations either being formed during deposition or after deposition by selective removal of sections of the deposited film. The implantable medical grafts are suitable for use as endoluminal or surgical grafts and may be used as vascular grafts, stent-grafts, skin grafts, shunts, bone grafts, surgical patches, non-vascular conduits, valvular leaflets, filters, occlusion membranes, artificial sphincters, tendons and ligaments.

公开(公告)号：US20140109383A1

公开(公告)日：2014-04-24

申请号：US13654923

申请日：2012-10-18

Applicant: PALMAZ SCIENTIFIC, INC.

Inventor： Scott CARPENTER ,  Armando GARZA ,  Julio C. PALMAZ

IPC: B23P25/00

CPC classification number: A61L31/022 ,  A61F2/0077 ,  A61F2/2418 ,  A61F2/30771 ,  A61F2/36 ,  A61F2/915 ,  A61F2002/0081 ,  A61F2002/30029 ,  A61F2002/3083 ,  A61F2002/30838 ,  A61F2002/30925 ,  A61F2240/00 ,  A61F2240/001 ,  A61L31/14 ,  A61L2400/18 ,  Y10T29/49982

Abstract: The invention relates to methods and apparatus for manufacturing medical devices wherein the medical device has a surface treated to promote the migration of cells onto the surface of the medical device. In particular, the surface of the medical device has at least one topographical feature formed therein.

Abstract translation: 本发明涉及用于制造医疗装置的方法和装置，其中医疗装置具有被处理以促进细胞迁移到医疗装置表面上的表面。 特别地，医疗装置的表面具有形成在其中的至少一个形貌特征。