公开(公告)号：US20220323364A1

公开(公告)日：2022-10-13

申请号：US17741173

申请日：2022-05-10

Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

Inventor： Hooman Hafezi ,  Timothy Robertson ,  Olivier Colliou ,  Mark Zdeblick

IPC: A61K9/20 ,  H01M10/04 ,  A61B5/00 ,  A61B5/07 ,  A61B5/145 ,  A61B5/1473 ,  A61K49/00

Abstract: Controlled activation identifiers for use in ingestible compositions, such as pharma-informatics enabled compositions, are provided. The identifiers include a controlled activation element that provides for activation of the identifier in response to the presence of a predetermined stimulus at a target site of interest. The invention finds use in a variety of different applications, including but not limited to, monitoring of therapeutic regimen compliance, tracking the history of pharmaceutical agents, etc.

公开(公告)号：US11357730B2

公开(公告)日：2022-06-14

申请号：US16235528

申请日：2018-12-28

Applicant: OTSUKA PHARMACEUTICAL CO., LTD.

Inventor： Hooman Hafezi ,  Timothy Robertson ,  Olivier Colliou ,  Mark Zdeblick

IPC: A61B5/00 ,  A61K9/20 ,  H01M10/04 ,  A61B5/07 ,  A61B5/145 ,  A61B5/1473 ,  A61K49/00 ,  A61J3/00

Abstract: Apparatuses for use with a pharmaceutically acceptable carrier. The apparatus can include a partial power source, which in turn includes electrodes or materials that are configured to generate an electrical potential upon contacting or being exposed to an ionic solution. The apparatus can further include a circuit electrically or communicatively coupled to the partial power source. The circuit can generate various types of signals, such as RF signals, when powered by the partial power source. The circuit is stably fittable to the pharmaceutically acceptable carrier. The apparatus can further include a barrier, a protective layer, or a membrane that isolates the electrodes or materials from the ionic solution and is configured to be dissolved by the ionic solution.