公开(公告)号：US20240240151A1

公开(公告)日：2024-07-18

申请号：US18448864

申请日：2023-08-11

申请人： OSSIUM HEALTH, INC.

发明人： Erik J. WOODS ,  Brian H. JOHNSTONE ,  Dongsheng GU ,  Hannah Marie MILLER

IPC分类号： C12N5/0775 ,  C12N9/52

CPC分类号： C12N5/0663 ,  C12N9/52 ,  C12N2509/00

摘要： Compositions and methods for the extraction mesenchymal cells from deceased donor bone, and therapeutic applications thereof, along with combination therapeutic applications comprising mesenchymal cells from deceased donors and bone marrow derived from deceased donors are presented.

公开(公告)号：US20210317415A1

公开(公告)日：2021-10-14

申请号：US17227217

申请日：2021-04-09

申请人： Ossium Health, Inc.

发明人： Erik J. WOODS ,  Brian H. JOHNSTONE

IPC分类号： C12N5/077 ,  C12N5/0775 ,  C12N5/0789

摘要： Provided herein are methods and systems for recovering bone marrow. The methods comprising perfusing a bone with a perfusion media and recovering the liberated bone marrow cells.

公开(公告)号：US20240260567A1

公开(公告)日：2024-08-08

申请号：US18545891

申请日：2023-12-19

申请人： Ossium Health, Inc.

发明人： Erik J. WOODS ,  Brian H. JOHNSTONE

IPC分类号： A01N1/02 ,  C12N5/0775 ,  C12N5/0789

CPC分类号： A01N1/0284 ,  A01N1/0221 ,  A01N1/0289 ,  C12N5/0647 ,  C12N5/0663 ,  C12N2509/00

摘要： The present disclosure relates to, at least, a vacuum-assisted method for infiltrating cadaver bone with a cryoprotectant and a method for rapidly warming the cryopreserved cadaver bone for bone marrow processing.

公开(公告)号：US20210214688A1

公开(公告)日：2021-07-15

申请号：US17199376

申请日：2021-03-11

申请人： Ossium Health, Inc.

发明人： Erik J. WOODS ,  Brian H. JOHNSTONE ,  Dongsheng GU ,  Aubrey Marie SHERRY ,  Kelsey Gwen MUSALL ,  John R. WOODS ,  James HARDIN ,  Alan HOOKS

IPC分类号： C12N5/0775 ,  A61B17/16 ,  A01N1/02

摘要： Methods are provided for extracting bone marrow cells from bone obtained from deceased donors, for preparing the bone marrow for cryopreservation and for obtaining desired cells from cryopreserved and fresh bone marrow.

公开(公告)号：US20240271098A1

公开(公告)日：2024-08-15

申请号：US18412312

申请日：2024-01-12

申请人： OSSIUM HEALTH, INC.

发明人： Erik J. WOODS ,  Brian H. JOHNSTONE ,  Dongsheng GU ,  Aubrey Marie SHERRY ,  Kelsey Gwen MUSALL ,  John R. WOODS ,  James HARDIN ,  Alan HOOKS

IPC分类号： C12N5/0775 ,  A01N1/02 ,  A61B17/00 ,  A61B17/16

CPC分类号： C12N5/0663 ,  A01N1/0221 ,  A61B17/1611 ,  A61B2017/00831

摘要： Methods are provided for extracting bone marrow cells from bone obtained from deceased donors, for preparing the bone marrow for cryopreservation and for obtaining desired cells from cryopreserved and fresh bone marrow.

公开(公告)号：US20240252541A1

公开(公告)日：2024-08-01

申请号：US18357976

申请日：2023-07-24

申请人： Ossium Health, Inc. ,  The Trustees of Columbia University in the City of New York

发明人： Erik J. WOODS ,  Brian H. JOHNSTONE ,  Dongsheng GU ,  Aubrey Marie SHERRY ,  Kelsey Gwen MUSALL ,  Kazuhiko YAMADA ,  Megan SYKES

IPC分类号： A61K35/28 ,  A61K31/44 ,  A61K45/06 ,  A61P37/06 ,  C07K16/26 ,  C07K16/28

CPC分类号： A61K35/28 ,  A61K31/44 ,  A61K45/06 ,  A61P37/06 ,  C07K16/26 ,  C07K16/2806 ,  C07K16/2875

摘要： Described herein are methods of cell therapies. Also described herein are methods of establishing a mixed chimerism, and/or preventing a rejection of a donor organ in a subject wherein said subject has received an organ transplant, the method comprising administering to said subject a population of hematopoietic cells, wherein said organ transplant comprises a heart transplant.

公开(公告)号：US20240207322A1

公开(公告)日：2024-06-27

申请号：US18456422

申请日：2023-08-25

申请人： OSSIUM HEALTH, INC.

发明人： Erik J. WOODS ,  Brian H. JOHNSTONE ,  Dongsheng GU ,  Aubrey Marie SHERRY ,  Kelsey Gwen MUSALL ,  Megan SYKES ,  Tomoaki KATO ,  Jianing FU

IPC分类号： A61K35/28 ,  A61K31/436 ,  A61K35/17 ,  A61K35/38 ,  A61K38/17 ,  A61P37/06 ,  C12N5/0783 ,  C12N5/0789

CPC分类号： A61K35/28 ,  A61K31/436 ,  A61K35/17 ,  A61K35/38 ,  A61K38/1774 ,  A61P37/06 ,  C12N5/0636 ,  C12N5/0647

摘要： Described herein are methods of cell therapies. Also described herein are methods of generating donor derived T cells in an organ transplant recipient, by administering bone marrow stem cells to the organ transplant recipient about 1 to about 30 days after the organ transplant recipient receives one or more organ transplants.

公开(公告)号：US20240164371A1

公开(公告)日：2024-05-23

申请号：US18352942

申请日：2023-07-14

申请人： OSSIUM HEALTH, INC.

发明人： Erik J. WOODS ,  Brian H. JOHNSTONE ,  Dongsheng GU ,  Aubrey Marie SHERRY ,  Kelsey Gwen MUSALL

IPC分类号： A01N1/02

CPC分类号： A01N1/0284 ,  A01N1/0221 ,  A01N1/0252

摘要： Methods, systems, and compositions are provided for extracting bone marrow cells from bone obtained from deceased donors, for preparing the bone marrow for cryopreservation, and for obtaining desired cells from cryopreserved and fresh bone marrow

公开(公告)号：US20230232820A1

公开(公告)日：2023-07-27

申请号：US18155657

申请日：2023-01-17

申请人： Ossium Health, Inc.

发明人： Erik J. WOODS ,  Brian H. JOHNSTONE

IPC分类号： A01N1/02 ,  C12N5/0775 ,  C12N5/0789

CPC分类号： A01N1/0284 ,  A01N1/0289 ,  A01N1/0221 ,  C12N5/0663 ,  C12N5/0647 ,  C12N2509/10 ,  C12N2501/734 ,  C12N2523/00

摘要： The present disclosure relates to, at least, a vacuum-assisted method for infiltrating cadaver bone with a cryoprotectant and a method for rapidly warming the cryopreserved cadaver bone for bone marrow processing.

公开(公告)号：US20220195393A1

公开(公告)日：2022-06-23

申请号：US17667434

申请日：2022-02-08

申请人： Ossium Health, Inc.

发明人： Erik J. WOODS ,  Hannah Marie MILLER ,  Brian H. JOHNSTONE

IPC分类号： C12N5/0775

摘要： Described herein are methods and systems for preparing samples of stem cells for direct infusion. Some of the methods and systems described herein comprise hypothermic storage of the stem cells. The methods and systems described herein can supplement shipment of stem cells across long distances such that the stem cells are prepared for direct infusion upon receipt of the cells.