公开(公告)号：US20180362542A1

公开(公告)日：2018-12-20

申请号：US16062680

申请日：2016-12-14

Applicant: Novartis AG

Inventor： Robert John AVERSA ,  Matthew T. BURGER ,  Michael Patrick DILLON ,  Thomas A. DINEEN, Jr. ,  Rajesh KARKI ,  Savrithi RAMURTHY ,  Vivek RAUNIYAR ,  Richard ROBINSON ,  Patrick James SARVER

IPC: C07D498/04 ,  C07D491/044 ,  C07D487/04 ,  A61P35/00

CPC classification number: C07D498/04 ,  A61P35/00 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044

Abstract: The present invention provides compounds of Formula (A): (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent, and methods of using the compositions and combinations to treat conditions including cancers.