公开(公告)号：US20240062370A1

公开(公告)日：2024-02-22

申请号：US18446925

申请日：2023-08-09

Applicant: Northwestern University

Inventor： Sourav Halder ,  Ethan M. Johnson ,  Jun Yamasaki ,  Peter J. Kahrilas ,  Michael Markl ,  John Erik Pandolfino ,  Neelesh A. Patankar

IPC: G06T7/00 ,  G06T7/11

CPC classification number: G06T7/0012 ,  G06T7/11 ,  G06T2207/20081 ,  G06T2207/30004

Abstract: Esophageal bolus transport and esophageal mechanics are quantified from medical imaging data, such as dynamic magnetic resonance imaging (“MRI”) data, computed tomography (“CT”) data, or the like. A machine learning model is used to process geometric or other spatiotemporal parameters of a bolus imaged with medical imaging in order to estimate quantitative parameters of the bolus and/or esophagus, such as cross-sectional area, fluid velocity, and fluid pressure. From these values, other parameters can be computed, such as esophageal stiffness and active relaxation.

公开(公告)号：US20220405923A1

公开(公告)日：2022-12-22

申请号：US17779124

申请日：2020-11-23

Applicant: Northwestern University

Inventor： John Erik Pandolfino ,  Neelesh Ashok Patankar ,  Sourv Halder ,  Shashank Acharya ,  Peter James Kahrilas

IPC: G06T7/00 ,  G06T7/11 ,  G06T7/20 ,  G06T3/40 ,  G16H15/00 ,  G16H30/40

Abstract: Flow through tubular organs (e.g., the esophagus) is analyzed based on fluid mechanics analysis of medical images. Using computational fluid dynamics, a reduced-order model is constructed and implemented to predict flow rate and fluid pressure developed inside flexible tubular organs inside the body. As one non-limiting example, the constructed model can be applied to analyze esophageal transport using fluoroscopy image sequences to predict flow rate, pressure, esophagus wall stiffness, and active relaxation.

公开(公告)号：US10898091B2

公开(公告)日：2021-01-26

申请号：US15546986

申请日：2016-02-02

Applicant: Northwestern University

Inventor： John Erik Pandolfino ,  Zhiyue Lin ,  Peter J. Kahrilas ,  John O'Dea ,  Adrian McHugh

IPC: A61B5/03 ,  A61B5/053 ,  A61B5/00 ,  A61B1/273

Abstract: Systems, methods, and apparatus for esophageal panometry are provided. An example method includes capturing measurement data including an area and a pressure of an esophageal body via a measurement device positioned with respect to the esophageal body; generating representations of the exported measurement data; analyzing the measurement data to determine esophageal reactivity based on the area and pressure; assessing esophageal function based on the determined esophageal reactivity; and outputting an indication of esophageal function.

公开(公告)号：US20240041343A1

公开(公告)日：2024-02-08

申请号：US18546592

申请日：2022-02-16

Applicant: Northwestern University

Inventor： John Erik Pandolfino ,  Dustin Allan Carlson ,  Wenjun Kou

IPC: A61B5/03 ,  A61B5/00 ,  A61M25/10 ,  A61B5/11

CPC classification number: A61B5/037 ,  A61B5/7267 ,  A61M25/1011 ,  A61B5/1107 ,  A61B5/687 ,  A61B5/6853 ,  A61B2562/0247

Abstract: A catheter-based baro-hydrometer device measures or otherwise monitors esophageal function. The device includes a segmented balloon design, including a first and second balloon whose fill volumes can be independently controlled. In general, the device leverages secondary peristalsis related to balloon distention in order to study esophageal function. Pressure sensors coupled to the balloons record pressure data, which can be classified and processed to measure or otherwise monitor esophageal function.

公开(公告)号：US20230018807A1

公开(公告)日：2023-01-19

申请号：US17778340

申请日：2020-11-19

Applicant: Northwestern University

Inventor： John Erik Pandolfino ,  Neelesh Ashok Patankar ,  Shashank Acharya ,  Sourav Halder ,  Wenjun Kou ,  Peter James Kahrilas ,  Dustin Allan Carlson

IPC: A61B5/00 ,  A61M25/10

Abstract: A fluid mechanics-based analysis tool is implemented to compute pressure field data, fluid velocity data, and/or muscular work data in a lumen or other tubular organ or structure from planimetry and pressure data (e.g., measured using a balloon dilation or other planimetry catheter). In this way, flow data can be estimated, which are otherwise insensible from current planimetry catheter technologies due to economic and/or manufacturing limitations.

公开(公告)号：US20180008156A1

公开(公告)日：2018-01-11

申请号：US15546986

申请日：2016-02-02

Applicant: Northwestern University

Inventor： John Erik Pandolfino ,  Zhiyue Lin ,  Peter J. Kahrilas ,  John O'Dea ,  Adrian McHugh

IPC: A61B5/03 ,  A61B5/00 ,  A61B1/273

CPC classification number: A61B5/037 ,  A61B1/273 ,  A61B5/6853

Abstract: Systems, methods, and apparatus for esophageal panometry are provided. An example method includes capturing measurement data including an area and a pressure of an esophageal body via a measurement device positioned with respect to the esophageal body; generating representations of the exported measurement data; analyzing the measurement data to determine esophageal reactivity based on the area and pressure; assessing esophageal function based on the determined esophageal reactivity; and outputting an indication of esophageal function.