公开(公告)号：US20060263343A1

公开(公告)日：2006-11-23

申请号：US11433776

申请日：2006-05-15

申请人： Norma Kenyon ,  Cynthia Healy ,  Steven Koester ,  Xiumin Xu

发明人： Norma Kenyon ,  Cynthia Healy ,  Steven Koester ,  Xiumin Xu

IPC分类号： C12Q1/68 ,  G01N33/567 ,  A61K48/00 ,  A61K39/395 ,  A61K31/573 ,  A61K31/7048 ,  A61K31/4745 ,  G01N33/53 ,  A61K39/00

CPC分类号： G01N33/56972 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/96436 ,  G01N2800/24 ,  G01N2800/245

摘要： An antigen-specific T-cell response to alloantigen, tissue-specific antigen (e.g., islet antigen or other autoantigens involved in autoimmune disease), or self (or host) antigen is detected at an early stage of graft rejection or recurrent autoimmunity. An increase in cytotoxic lymphocyte gene (CLG) expression in peripheral blood is a risk factor for development of deleterious immune responses, which may be confirmed by functional assays. For example, the distinction between production of regulatory or inflammatory cytokines by T cells may dissect the type of immune response which is being induced: the survival of transplanted islet cells used to treat type 1 diabetes may be monitored, loss of the transplant by graft rejection (i.e., an alloantigen target) may be distinguished from autoimmune disease (i.e., a self or host antigen target).

摘要翻译： 在移植排斥反应或复发性自身免疫的早期阶段检测抗同种异体抗原，组织特异性抗原（例如，参与自身免疫疾病的胰岛抗原或其他自身抗原）或自身（或宿主）抗原的抗原特异性T细胞应答。 外周血中细胞毒性淋巴细胞基因（CLG）表达的增加是有害免疫应答发展的危险因素，这可以通过功能测定来证实。 例如，由T细胞产生调节性炎性细胞因子或炎性细胞因子之间的区别可能会解剖正在诱导的免疫应答的类型：可以监测用于治疗1型糖尿病的移植胰岛细胞的存活，移植物排斥的丧失 （即，同种异体抗原靶）可以与自身免疫疾病（即自身或宿主抗原靶）区分开。