公开(公告)号：US11143585B2

公开(公告)日：2021-10-12

申请号：US16234597

申请日：2018-12-28

Applicant: National Applied Research Laboratories

Inventor： I-Fang Cheng ,  Tzu-Ying Chen ,  Yi-Ling Chen

IPC: B03C7/02 ,  B03C7/00 ,  B03C5/02 ,  B03C5/00 ,  G01N15/06 ,  C12Q1/18

Abstract: A photoelectrical device for detection of bacterial cell density includes a substrate, a driving electrode layer, an AC power source and a photoelectric conversion layer. The driving electrode layer is disposed on the substrate and includes a central electrode and a peripheral electrode pattern surrounding the central electrode. A fluid sample is disposed on the driving electrode layer. The AC power source is electrically connected to the driving electrode layer, and used to produce a non-uniform alternating electric field in the fluid sample on the driving electrode layer for driving the target bioparticles to gather up on the central electrode to form a particle cluster. The photoelectric conversion layer is used for receiving a light detecting beam after passing through the particle cluster and outputting an electric current based on the optical density of light detecting beam. The electric current changes as a concentration of the target bioparticles changes.

公开(公告)号：US20200209135A1

公开(公告)日：2020-07-02

申请号：US16234597

申请日：2018-12-28

Applicant: National Applied Research Laboratories

Inventor： I-Fang Cheng ,  Tzu-Ying Chen ,  Yi-Ling Chen

IPC: G01N15/06 ,  C12Q1/18

Abstract: A photoelectrical device for detection of bacterial cell density includes a substrate, a driving electrode layer, an AC power source and a photoelectric conversion layer. The driving electrode layer is disposed on the substrate and includes a central electrode and a peripheral electrode pattern surrounding the central electrode. A fluid sample is disposed on the driving electrode layer. The AC power source is electrically connected to the driving electrode layer, and used to produce a non-uniform alternating electric field in the fluid sample on the driving electrode layer for driving the target bioparticles to gather up on the central electrode to form a particle cluster. The photoelectric conversion layer is used for receiving a light detecting beam after passing through the particle cluster and outputting an electric current based on the optical density of light detecting beam. The electric current changes as a concentration of the target bioparticles changes.

公开(公告)号：US20140083855A1

公开(公告)日：2014-03-27

申请号：US14030830

申请日：2013-09-18

Applicant: National Applied Research Laboratories

Inventor： I-Fang Cheng ,  Fu-Liang Yang ,  Hsien-Chang Chang ,  Tzu-Ying Chen

IPC: B03C5/00

CPC classification number: B03C5/005 ,  B03C5/026 ,  B03C2201/26

Abstract: A bio-chip adapted for separating and concentrating particles in a solution includes a chip body defining a receiving space therein for receiving the solution, an inner electrode disposed in the receiving space, an outer electrode unit disposed in the receiving space of the chip body and including a first outer electrode that is spaced apart from and surrounds the inner electrode, and a second outer electrode that is spaced apart from and surrounds the first outer electrode, and a power source electrically connected to the inner electrode, the first outer electrode, and the second outer electrode. A method for using the bio-chip to separating and concentrating the particles in the solution is also disclosed in the present invention.

Abstract translation: 适于分离和浓缩溶液中的颗粒的生物芯片包括限定其中用于接收溶液的接收空间的芯片体，设置在容纳空间中的内部电极，设置在芯片体的容纳空间中的外部电极单元，以及 包括与内部电极间隔开并围绕内部电极的第一外部电极，以及与第一外部电极间隔开并围绕第一外部电极的第二外部电极，以及电连接到内部电极，第一外部电极和 第二外电极。 在本发明中还公开了使用生物芯片分离和浓缩溶液中的颗粒的方法。

公开(公告)号：US09498784B2

公开(公告)日：2016-11-22

申请号：US14030830

申请日：2013-09-18

Applicant: National Applied Research Laboratories

Inventor： I-Fang Cheng ,  Fu-Liang Yang ,  Hsien-Chang Chang ,  Tzu-Ying Chen

IPC: B03C5/00 ,  B03C5/02

CPC classification number: B03C5/005 ,  B03C5/026 ,  B03C2201/26

Abstract: A bio-chip adapted for separating and concentrating particles in a solution includes a chip body defining a receiving space therein for receiving the solution, an inner electrode disposed in the receiving space, an outer electrode unit disposed in the receiving space of the chip body and including a first outer electrode that is spaced apart from and surrounds the inner electrode, and a second outer electrode that is spaced apart from and surrounds the first outer electrode, and a power source electrically connected to the inner electrode, the first outer electrode, and the second outer electrode. A method for using the bio-chip to separating and concentrating the particles in the solution is also disclosed in the present invention.

Abstract translation: 适于分离和浓缩溶液中的颗粒的生物芯片包括限定其中用于接收溶液的接收空间的芯片体，设置在容纳空间中的内部电极，设置在芯片体的容纳空间中的外部电极单元，以及 包括与内部电极间隔开并围绕内部电极的第一外部电极，以及与第一外部电极间隔开并围绕第一外部电极的第二外部电极，以及电连接到内部电极，第一外部电极和 第二外电极。 在本发明中还公开了使用生物芯片分离和浓缩溶液中的颗粒的方法。