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公开(公告)号：US20240327919A1
公开(公告)日：2024-10-03
申请号：US18747138
申请日：2024-06-18
申请人： Natera, Inc.
发明人： MATTHEW RABINOWITZ , Matthew Micah HILL , Bernhard ZIMMERMANN , Johan BANER , George GEMELOS , Milena Eser BANJEVIC , Allison RYAN , Styrmir SIGURJONSSON , Zachary DEMKO
IPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q1/6811 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874
CPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q1/6811 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2600/156
摘要： The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US20240318252A1
公开(公告)日：2024-09-26
申请号：US18733659
申请日：2024-06-04
申请人： Natera, Inc.
发明人： Matthew RABINOWITZ , Matthew Micah HILL , Bernhard A. ZIMMERMANN , Johan BANER , George GEMELOS , Milena BANJEVIC , Allison RYAN , Styrmir SIGURJONSSON , Zachary DEMKO
IPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q1/6811 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874
CPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q1/6811 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2600/156
摘要： The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US20210189498A1
公开(公告)日：2021-06-24
申请号：US17196822
申请日：2021-03-09
申请人： Natera, Inc.
发明人： Joshua BABIARZ , Tudor Pompiliu CONSTANTIN , Lane A. EUBANK , George GEMELOS , Matthew Micah HILL , Huseyin Eser KIRKIZLAR , Matthew RABINOWITZ , Onur SAKARYA , Styrmir SIGURJONSSON , Bernhard ZIMMERMANN
IPC分类号： C12Q1/6883 , C12Q1/6811 , C12Q1/6848 , C12Q1/6809 , C12Q1/6851 , C12Q1/6844 , C12Q1/6855 , C12Q1/6874
摘要： The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US20200232037A1
公开(公告)日：2020-07-23
申请号：US16829133
申请日：2020-03-25
申请人： Natera, Inc.
发明人： Joshua BABIARZ , Tudor Pompiliu CONSTANTIN , Lane A. EUBANK , George GEMELOS , Matthew Micah HILL , Huseyin Eser KIRKIZLAR , Matthew RABINOWITZ , Onur SAKARYA , Styrmir SIGURJONSSON , Bernhard ZIMMERMANN
IPC分类号： C12Q1/6883 , C12Q1/6848 , C12Q1/6811 , C12Q1/6851 , C12Q1/6874 , C12Q1/6855 , C12Q1/6809
摘要： The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US20200208221A1
公开(公告)日：2020-07-02
申请号：US16817117
申请日：2020-03-12
申请人： Natera, Inc.
发明人： Joshua BABIARZ , Tudor Pompiliu CONSTANTIN , Lane A. EUBANK , George GEMELOS , Matthew Micah HILL , Huseyin Eser KIRKIZLAR , Matthew RABINOWITZ , Onur SAKARYA , Styrmir SIGURJONSSON , Bernhard ZIMMERMANN
IPC分类号： C12Q1/6883 , C12Q1/6851 , C12Q1/6809 , C12Q1/6874 , C12Q1/6855 , C12Q1/6848 , C12Q1/6811
摘要： The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US20190309365A1
公开(公告)日：2019-10-10
申请号：US16412353
申请日：2019-05-14
申请人： Natera, Inc.
发明人： Joshua BABIARZ , Tudor Pompiliu CONSTANTIN , Lane A. EUBANK , George GEMELOS , Matthew Micah HILL , Huseyin Eser KIRKIZLAR , Matthew RABINOWITZ , Onur SAKARYA , Styrmir SIGURJONSSON , Bernhard ZIMMERMANN
IPC分类号： C12Q1/6883 , C12Q1/6874 , C12Q1/6855 , C12Q1/6848 , C12Q1/6811
摘要： The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US20190271043A1
公开(公告)日：2019-09-05
申请号：US16412331
申请日：2019-05-14
申请人： Natera, Inc.
发明人： Joshua BABIARZ , Tudor Pompiliu CONSTANTIN , Lane A. EUBANK , George GEMELOS , Matthew Micah HILL , Huseyin Eser KIRKIZLAR , Matthew RABINOWITZ , Onur SAKARYA , Styrmir SIGURJONSSON , Bernhard ZIMMERMANN
IPC分类号： C12Q1/6883 , C12Q1/6848 , C12Q1/6811
摘要： The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US20190256919A1
公开(公告)日：2019-08-22
申请号：US16399947
申请日：2019-04-30
申请人： Natera, Inc.
发明人： Joshua BABIARZ , Tudor Popiliu CONSTANTIN , Lane A. EUBANK , George GEMELOS , Matthew Micah HILL , Huseyin Eser KIRKIZLAR , Matthew RABINOWITZ , Onur SAKARYA , Styrmir SIGURJONSSON , Bernhard ZIMMERMANN
IPC分类号： C12Q1/6883 , C12Q1/6848 , C12Q1/6811
摘要： The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US20240352513A1
公开(公告)日：2024-10-24
申请号：US18753991
申请日：2024-06-25
申请人： Natera, Inc.
发明人： Joshua BABIARZ , Tudor Pompiliu CONSTANTIN , Lane A. EUBANK , George GEMELOS , Matthew Micah HILL , Huseyin Eser KIRKIZLAR , Matthew RABINOWITZ , Onur SAKARYA , Styrmir SIGURJONSSON , Bernhard ZIMMERMANN
IPC分类号： C12Q1/686 , C12Q1/68 , C12Q1/6811 , C12Q1/6848 , C12Q1/6874 , C12Q1/6883
CPC分类号： C12Q1/686 , C12Q1/68 , C12Q1/6811 , C12Q1/6848 , C12Q1/6874 , C12Q1/6883 , C12Q2600/156
摘要： The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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公开(公告)号：US20240309464A1
公开(公告)日：2024-09-19
申请号：US18678577
申请日：2024-05-30
申请人： Natera, Inc.
发明人： Joshua BABIARZ , Tudor Pompiliu CONSTATIN , Lane A. EUBANK , George GEMELOS , Matthew Micah HILL , Huseyin Eser KIRKIZLAR , Matthew RABIBOWITZ , Onur SAKARYA , Styrmir SIGURJONSSON , Bernhard ZIMMERMANN
IPC分类号： C12Q1/6886 , C12Q1/6869 , G06N7/01 , G06N20/00 , G16B15/00 , G16B20/00 , G16B20/10 , G16B20/20 , G16B25/00 , G16B25/20 , G16B40/00 , G16B40/20 , G16H10/40 , G16H50/20 , G16Z99/00
CPC分类号： C12Q1/6886 , C12Q1/6869 , G06N7/01 , G06N20/00 , G16B15/00 , G16B20/00 , G16B20/10 , G16B20/20 , G16B25/00 , G16B40/00 , G16B40/20 , G16H10/40 , G16H50/20 , G16Z99/00 , C12Q2539/10 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172 , G16B25/20
摘要： The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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