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1.发明授权Skin state analyzing method, skin state analyzing apparatus, and computer-readable medium storing skin state analyzing program 有权皮肤状态分析方法，皮肤状态分析装置和存储皮肤状态分析程序的计算机可读介质公开(公告)号：US08591414B2
公开(公告)日：2013-11-26
申请号：US13405807
申请日：2012-02-27
申请人： Naomi Kitamura , Yuji Masuda , Hiroyuki Ohnishi
发明人： Naomi Kitamura , Yuji Masuda , Hiroyuki Ohnishi
CPC分类号： A61B5/442 , A61B5/0082 , A61B5/743 , A61B5/7435 , G06F19/00 , G06F19/321 , G16H50/20
摘要： A skin state analyzing method for analyzing the skin state of an examinee using an image of the skin of the examinee includes an analyzing step of analyzing at least one of texture/pores, spots, skin tone, and sebum of the skin from the image, a storing step of storing the image and an analysis result obtained from the analyzing step in association with skin examination date/time information and examinee information, a display screen generating step of generating a screen displaying the image and the analysis result of the examinee stored in the storing step, and an output step of outputting the information generated in the display screen generating step.
摘要翻译： 使用受检者皮肤的图像分析受检者的皮肤状态的皮肤状态分析方法包括分析步骤，从图像分析皮肤的纹理/毛孔，斑点，肤色和皮脂中的至少一种， 存储步骤，用于存储与皮肤检查日期/时间信息和受检者信息相关联的从分析步骤获得的图像和分析结果;显示屏幕生成步骤，生成显示图像的屏幕和存储在该图像中的受检者的分析结果 存储步骤，以及输出步骤，输出在显示画面生成步骤中生成的信息。
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2.发明申请SKIN STATE ANALYZING METHOD, SKIN STATE ANALYZING APPARATUS, AND COMPUTER-READABLE MEDIUM STORING SKIN STATE ANALYZING PROGRAM 审中-公开皮肤状态分析方法，皮肤状态分析装置和计算机可读介质储存皮肤状态分析程序公开(公告)号：US20090054744A1
公开(公告)日：2009-02-26
申请号：US11912916
申请日：2006-04-21
申请人： Naomi Kitamura , Yuji Masuda , Hiroyuki Ohnishi
发明人： Naomi Kitamura , Yuji Masuda , Hiroyuki Ohnishi
IPC分类号： A61B5/00
CPC分类号： A61B5/442 , A61B5/0082 , A61B5/743 , A61B5/7435 , G06F19/321 , G16H50/20
摘要： A skin state analyzing method for analyzing the skin state of an examinee using an image of the skin of the examinee includes an analyzing step of analyzing at least one of texture/pores, spots, skin tone, and sebum of the skin from the image, a storing step of storing the image and an analysis result obtained from the analyzing step in association with skin examination date/time information and examinee information, a display screen generating step of generating a screen displaying the image and the analysis result of the examinee stored in the storing step, and an output step of outputting the information generated in the display screen generating step.
摘要翻译： 使用受检者皮肤的图像分析受检者的皮肤状态的皮肤状态分析方法包括分析步骤，从图像分析皮肤的纹理/毛孔，斑点，肤色和皮脂中的至少一种， 存储步骤，用于存储与皮肤检查日期/时间信息和受检者信息相关联的从分析步骤获得的图像和分析结果;显示屏幕生成步骤，生成显示图像的屏幕和存储在该图像中的受检者的分析结果 存储步骤，以及输出步骤，输出在显示画面生成步骤中生成的信息。
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3.发明授权Hepatic parenchymal cell growth factor gene encoding the same, process for producing the factor and transformants producing the factor 失效肝实质细胞生长因子基因编码相同，产生因子的过程和产生因子的转化体
公开(公告)号：US5500354A
公开(公告)日：1996-03-19
申请号：US89417
申请日：1993-07-09
申请人： Naomi Kitamura , Keiji Miyazawa , Yasushi Daikuhara , Hirohito Tsubouchi , Daiji Naka , Kazuhiro Takahashi , Rie Matsui , Yoshiko Yoshiyama , Takehisa Ishii
发明人： Naomi Kitamura , Keiji Miyazawa , Yasushi Daikuhara , Hirohito Tsubouchi , Daiji Naka , Kazuhiro Takahashi , Rie Matsui , Yoshiko Yoshiyama , Takehisa Ishii
CPC分类号： C07K14/4753 , A61K38/00
摘要： According to the present invention, there are provided hepatic parenchymal cell growth factor obtained by recombinant DNA technology, a gene coding for the factor, an expression vector capable of expressing the gene, a cell, in particular animal cell, transformed with the expression vector, and a process for producing the hepatic parenchymal cell growth factor.
摘要翻译： 根据本发明，提供了通过重组DNA技术获得的肝实质细胞生长因子，编码该因子的基因，能够表达该基因的表达载体，用表达载体转化的细胞，特别是动物细胞， 以及肝实质细胞生长因子的制造方法。
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4.发明授权Hepatocyte growth factor activating protease and gene encoding the protease 失效肝细胞生长因子激活蛋白酶和编码蛋白酶的基因
公开(公告)号：US5466593A
公开(公告)日：1995-11-14
申请号：US148910
申请日：1993-11-05
CPC分类号： C12N9/64 , C07K14/475 , C07K14/4753 , C12N9/6421
摘要： A gene encoding a protease derived from human serum and having an activity to convert single-chain hepatocyte growth factor (HGF) into active two-chain HGF and a method of producing the protease by the use of said gene are provided. A method of producing a precursor protein of said protease is also provided.
摘要翻译： 提供了编码来自人血清并具有将单链肝细胞生长因子（HGF）转化为活性双链HGF的活性的基因的编码基因和使用所述基因产生蛋白酶的方法。 还提供了产生所述蛋白酶的前体蛋白质的方法。
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公开(公告)号：US5731412A
公开(公告)日：1998-03-24
申请号：US685660
申请日：1996-07-24
CPC分类号： C07K14/8114
摘要： A novel protein having inhibitory activity on the protease activity of hepatocyte growth factor (HGF) activator was purified and isolated, and its molecular weight (ca. 30,000 daltons) and partial amino acid sequence were determined. A gene coding for the protein was cloned, and the gene DNA was incorporated into a vector, for transforming host cells. Cultivation of the transformant gave the desired protein. The protein can be used as an in vivo or in vitro control factor for HGF or HGF activator. It is also useful as an antigen to be used in producing an antibody to be used as means for kinetic studies of the protein, or as a standard in assay systems therefor.
摘要翻译： 纯化并分离出对肝细胞生长因子（HGF）活化剂的蛋白酶活性具有抑制活性的新型蛋白质，测定其分子量（约30,000道尔顿）和部分氨基酸序列。 克隆编码该蛋白的基因，并将基因DNA并入载体中，用于转化宿主细胞。 转化体的培养给出了所需的蛋白质。 该蛋白质可用作HGF或HGF活化剂的体内或体外控制因子。 它也可用作生产用作蛋白质动力学研究手段的抗体或作为其测定系统中的标准物的抗原。
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6.发明授权DNA fragments coding for antigens specific to non-A non-B hepatitis, expression vectors containing said DNA fragments, transformants and process for producing said antigens 失效编码非A非乙型肝炎特异性抗原的DNA片段，含有所述DNA片段的表达载体，转化体和产生所述抗原的方法
公开(公告)号：US5032511A
公开(公告)日：1991-07-16
申请号：US168357
申请日：1988-03-15
申请人： Kazuhiro Takahashi , Tatsurou Shibui , Michiru Kamizono , Rie Matsui , Yutaka Teranishi , Shigetada Nakanishi , Naomi Kitamura
发明人： Kazuhiro Takahashi , Tatsurou Shibui , Michiru Kamizono , Rie Matsui , Yutaka Teranishi , Shigetada Nakanishi , Naomi Kitamura
CPC分类号： C07K14/005 , C12N2770/24222
摘要： Provided herein are a DNA fragment which contains a base sequence coding for a non-A non-B hepatitis-specific antigenic protein occurring in cells of the liver affected with non-A non-B hepatitis, an expression vector in which said DNA fragment is inserted into a cloning site present downstream from a promoter thereof, a transformant obtained by introducing said expression vector into a host, and a process for producing said antigenic protein which comprises providing said expression vector, transforming a host with said expression vector, culturing the transforming host and collecting the protein produced therein.
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公开(公告)号：US06465622B2
公开(公告)日：2002-10-15
申请号：US09765449
申请日：2001-01-22
IPC分类号： C07K14453
CPC分类号： C07K14/8114
摘要： A novel protein having inhibitory activity on the protease activity of hepatocyte growth factor (HGF) activator was purified and isolated, and its molecular weight (ca. 40,000 daltons) and its N-terminal and partial amino acid sequences were determined. A gene coding for the protein was cloned, and the gene DNA was incorporated into a vector, for transforming host cells. Cultivation of the transformant gave the desired protein. The protein can be used as an in vivo or in vitro control factor for HGF or HGF activator. It is also useful as an antigen to be used in producing an antibody to be used as means for kinetic studies of the protein, or as a standard in assay systems therefor.
摘要翻译： 纯化并分离出具有对肝细胞生长因子（HGF）活化剂的蛋白酶活性的抑制活性的新型蛋白质，测定其分子量（约40,000道尔顿）及其N-末端部分氨基酸序列。 克隆编码该蛋白的基因，并将基因DNA并入载体中，用于转化宿主细胞。 转化体的培养给出了所需的蛋白质。 该蛋白质可用作HGF或HGF活化剂的体内或体外控制因子。 它也可用作生产用作蛋白质动力学研究手段的抗体或作为其测定系统中的标准物的抗原。
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公开(公告)号：US06225081B1
公开(公告)日：2001-05-01
申请号：US08685558
申请日：1996-07-24
IPC分类号： C12N1515
CPC分类号： C07K14/8114
摘要： A novel protein having inhibitory activity on the protease activity of hepatocyte growth factor (HGF) activator was purified and isolated, and its molecular weight (ca. 40,000 daltons) and its N-terminal and partial amino acid sequences were determined. A gene coding for the protein was cloned, and the gene DNA was incorporated into a vector, for transforming host cells. Cultivation of the transformant gave the desired protein. The protein can be used as an in vivo or in vitro control factor for HGF or HGF activator. It is also useful as an antigen to be used in producing an antibody to be used as means for kinetic studies of the protein, or as a standard in assay systems therefor.
摘要翻译： 纯化并分离出具有对肝细胞生长因子（HGF）活化剂的蛋白酶活性的抑制活性的新型蛋白质，测定其分子量（约40,000道尔顿）及其N-末端部分氨基酸序列。 克隆编码该蛋白的基因，并将基因DNA并入载体中，用于转化宿主细胞。 转化体的培养给出了所需的蛋白质。 该蛋白质可用作HGF或HGF活化剂的体内或体外控制因子。 它也可用作生产用作蛋白质动力学研究手段的抗体或作为其测定系统中的标准物的抗原。
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公开(公告)号：US5854396A
公开(公告)日：1998-12-29
申请号：US974196
申请日：1997-11-19
CPC分类号： C07K14/8114
摘要： A novel protein having inhibitory activity on the protease activity of hepatocyte growth factor (HGF) activator was purified and isolated, and its molecular weight (ca. 30,000 daltons) and partial amino acid sequence were determined. A gene coding for the protein was cloned, and the gene DNA was incorporated into a vector, for transforming host cells. Cultivation of the transformant gave the desired protein. The protein can be used as an in vivo or in vitro control factor for HGF or HGF activator. It is also useful as an antigen to be used in producing an antibody to be used as means for kinetic studies of the protein, or as a standard in assay systems therefor.
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10.发明授权Hepatocyte growth factor activating protease and gene encoding the protease 失效肝细胞生长因子激活蛋白酶和编码蛋白酶的基因
公开(公告)号：US5677164A
公开(公告)日：1997-10-14
申请号：US448937
申请日：1995-05-24
IPC分类号： C07K14/475 , C12N9/64 , C12N15/12 , C12N15/57
CPC分类号： C12N9/64 , C07K14/475 , C07K14/4753 , C12N9/6421
摘要： A gene encoding a protease derived from human serum and having an activity to convert single-chain hepatocyte growth factor (HGF) into active two-chain HGF and a method of producing the protease by the use of said gene are provided. A method of producing a precursor protein of said protease is also provided.
摘要翻译： 提供了编码来自人血清并具有将单链肝细胞生长因子（HGF）转化为活性双链HGF的活性的基因的编码基因和使用所述基因产生蛋白酶的方法。 还提供了产生所述蛋白酶的前体蛋白质的方法。
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