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公开(公告)号：US20130309239A1
公开(公告)日：2013-11-21
申请号：US13954318
申请日：2013-07-30
Applicant: Novo Nordisk A/S
Inventor： Vibeke Westphal Stennicke , Christine Brender Read , Susanne Nedergaard Grell , Charlotte Wiberg , Rune Salbo , Anette Henriksen , Soeren Padkjaer
IPC: C07K16/28
CPC classification number: C07K16/2803 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/75 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to antibodies that are capable of specifically binding TREM-1 and preventing the activation of TREM-1, a protein expressed on monocytes, macrophages and neutrophils. Such antibodies find utility in the treatment of individuals with an inflammatory disease, such as rheumatoid arthritis and inflammatory bowel disease.
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公开(公告)号：US10189904B2
公开(公告)日：2019-01-29
申请号：US15372600
申请日：2016-12-08
Applicant: Novo Nordisk A/S
Inventor： Vibeke Westphal Stennicke , Christine Brender Read , Susanne Nedergaard Grell , Charlotte Wiberg , Rune Salbo , Anette Henriksen , Soeren Padkjaer
IPC: A61K39/395 , C07K16/00 , C07K16/18 , C07K16/28 , A61K39/00
Abstract: The invention relates to antibodies that are capable of specifically binding TREM-1 and preventing the activation of TREM-1, a protein expressed on monocytes, macrophages and neutrophils. Such antibodies find utility in the treatment of individuals with an inflammatory disease, such as rheumatoid arthritis and inflammatory bowel disease.
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3.发明申请公开(公告)号：US20180105590A9
公开(公告)日：2018-04-19
申请号：US15372600
申请日：2016-12-08
Applicant: Novo Nordisk A/S
Inventor： Vibeke Westphal STENNICKE , Christine Brender Read , Susanne Nedergaard Grell , Charlotte Wiberg , Rune SaIbo , Anette Henriksen , Soeren Padkjaer
IPC: C07K16/28
CPC classification number: C07K16/2803 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/75 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to antibodies that are capable of specifically binding TREM-1 and preventing the activation of TREM-1, a protein expressed on monocytes, macrophages and neutrophils. Such antibodies find utility in the treatment of individuals with an inflammatory disease, such as rheumatoid arthritis and inflammatory bowel disease.
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4.发明授权Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) 有权在骨髓细胞-1（TREM-1）上表达的结合和阻断触发受体的抗体公开(公告)号：US09000127B2
公开(公告)日：2015-04-07
申请号：US13690748
申请日：2012-11-30
Applicant: Novo Nordisk A/S
Inventor： Vibeke Westphal Stennicke , Christine Brender Read , Susanne Nedergaard Grell , Charlotte Wiberg , Rune Salbo , Anette Henriksen , Soeren Padkjaer
IPC: A61K39/395 , C07K16/00 , C07K16/18 , C07K16/28 , A61K39/00
CPC classification number: C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/2896 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/74 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to antibodies that are capable of specifically binding TREM-1 and preventing the activation of TREM-1, a protein expressed on monocytes, macrophages and neutrophils. Such antibodies find utility in the treatment of individuals with an inflammatory disease, such as rheumatoid arthritis and inflammatory bowel disease.
Abstract translation: 本发明涉及能够特异性结合TREM-1并防止TREM-1的活化的抗体，TREM-1是在单核细胞，巨噬细胞和嗜中性粒细胞上表达的蛋白质。 这种抗体可用于治疗具有炎性疾病的个体，例如类风湿性关节炎和炎症性肠病。
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公开(公告)号：US10906965B2
公开(公告)日：2021-02-02
申请号：US16171131
申请日：2018-10-25
Applicant: Novo Nordisk A/S
Inventor： Vibeke Westphal Stennicke , Christine Brender Read , Joseph Leon Kuijper , Xiaoting Tang , Mark Heipel , Siv Annegrethe Hjorth
IPC: A61K39/395 , C07K16/18
Abstract: Disclosed herein is a method for identifying TREM-1's ligand and antibodies, or fragments thereof, which are capable of modifying the function of TREM-1's ligand. Antibodies that reduce or block TREM-1 activation may be identified and selected using this method. Antibodies that bind to TREM-1's ligand and reduce TREM-1 activity may be suitable for use as medicaments.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20170190775A1
公开(公告)日：2017-07-06
申请号：US15372600
申请日：2016-12-08
Applicant: Novo Nordisk A/S
Inventor： Vibeke Westphal STENNICKE , Christine Brender Read , Susanne Nedergaard Grell , Charlotte Wiberg , Rune SaIbo , Anette Henriksen , Soeren Padkjaer
IPC: C07K16/28
CPC classification number: C07K16/2803 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/75 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to antibodies that are capable of specifically binding TREM-1 and preventing the activation of TREM-1, a protein expressed on monocytes, macrophages and neutrophils. Such antibodies find utility in the treatment of individuals with an inflammatory disease, such as rheumatoid arthritis and inflammatory bowel disease.
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公开(公告)号：US20150018528A1
公开(公告)日：2015-01-15
申请号：US14376968
申请日：2012-11-30
Applicant: Novo Nordisk A/S
Inventor： Vibeke Westphal Stennicke , Christine Brender Read , Joe Kuijper , Xiaoting Tang , Mark Heipel , Siv Annegrethe Hjorth
IPC: C07K16/18
CPC classification number: C07K16/18 , C07K2317/565 , C07K2317/76
Abstract: Disclosed herein is a method for identifying TREM-1's ligand and antibodies, or fragments thereof, which are capable of modifying the function of TREM-1's ligand. Antibodies that reduce or block TREM-1 activation may be identified and selected using this method. Antibodies that bind to TREM-1's ligand and reduce TREM-1 activity may be suitable for use as medicaments.
Abstract translation: 本文公开了一种鉴定能够改变TREM-1配体功能的TREM-1的配体和抗体或其片段的方法。 可以使用该方法鉴定和选择减少或阻断TREM-1激活的抗体。 结合TREM-1的配体并降低TREM-1活性的抗体可能适合用作药物。
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8.发明申请ANTIBODIES THAT BIND AND BLOCK TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS-1 (TREM-1) 有权在MYELOID细胞-1（TREM-1）上表达的结合和阻断触发受体的抗体公开(公告)号：US20130211050A1
公开(公告)日：2013-08-15
申请号：US13690748
申请日：2012-11-30
Applicant: NOVO NORDISK A/S
Inventor： Vibeke Westphal Stennicke , Christine Brender Read , Susanne Nedergaard Grell , Charlotte Wiberg , Rune Salbo , Anette Henriksen , Soeren Padkjaer
IPC: C07K16/28
CPC classification number: C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/2896 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/74 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to antibodies that are capable of specifically binding TREM-1 and preventing the activation of TREM-1, a protein expressed on monocytes, macrophages and neutrophils. Such antibodies find utility in the treatment of individuals with an inflammatory disease, such as rheumatoid arthritis and inflammatory bowel disease.
Abstract translation: 本发明涉及能够特异性结合TREM-1并防止TREM-1的活化的抗体，TREM-1是在单核细胞，巨噬细胞和嗜中性粒细胞上表达的蛋白质。 这种抗体可用于治疗具有炎性疾病的个体，例如类风湿性关节炎和炎症性肠病。
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公开(公告)号：US10906975B2
公开(公告)日：2021-02-02
申请号：US16209627
申请日：2018-12-04
Applicant: Novo Nordisk A/S
Inventor： Vibeke Westphal Stennicke , Christine Brender Read , Susanne Nedergaard Grell , Charlotte Wiberg , Rune Salbo , Anette Henriksen , Soeren Padkjaer
IPC: A61K39/395 , C07K16/00 , C07K16/18 , C07K16/28 , A61K39/00
Abstract: The invention relates to antibodies that are capable of specifically binding TREM-1 and preventing the activation of TREM-1, a protein expressed on monocytes, macrophages and neutrophils. Such antibodies find utility in the treatment of individuals with an inflammatory disease, such as rheumatoid arthritis and inflammatory bowel disease.
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10.发明授权Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (TREM-1) 有权在骨髓细胞-1（TREM-1）上表达的结合和阻断触发受体的抗体公开(公告)号：US09550830B2
公开(公告)日：2017-01-24
申请号：US13954318
申请日：2013-07-30
Applicant: Novo Nordisk A/S
Inventor： Vibeke Westphal Stennicke , Christine Brender Read , Susanne Nedergaard Grell , Charlotte Wiberg , Rune Salbo , Anette Henriksen , Soeren Padkjaer
IPC: A61K39/395 , C07K16/00 , C07K16/18 , C07K16/28 , A61K39/00
CPC classification number: C07K16/2803 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/75 , C07K2317/76 , C07K2317/92
Abstract: The invention relates to antibodies that are capable of specifically binding TREM-1 and preventing the activation of TREM-1, a protein expressed on monocytes, macrophages and neutrophils. Such antibodies find utility in the treatment of individuals with an inflammatory disease, such as rheumatoid arthritis and inflammatory bowel disease.
Abstract translation: 本发明涉及能够特异性结合TREM-1并防止TREM-1的活化的抗体，TREM-1是在单核细胞，巨噬细胞和嗜中性粒细胞上表达的蛋白质。 这种抗体可用于治疗具有炎性疾病的个体，例如类风湿性关节炎和炎症性肠病。
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