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1.发明授权Systems and methods for a membrane-free electrolysis pump for an intraocular implant 有权用于眼内植入物的无电解电解泵的系统和方法公开(公告)号：US09375348B2
公开(公告)日：2016-06-28
申请号：US14181851
申请日：2014-02-17
申请人： NOVARTIS AG
发明人： Nicholas M. Gunn
CPC分类号： A61F9/00781 , F04B19/006 , F04B43/043
摘要： A microfluidic pump for implantation proximate an eye of a patient is provided herein. The pump includes a first substrate portion and a second substrate portion adjacent the first and a chamber that has a bottom surface and a top surface provided by the first and second substrate portions. A gas is produced within the chamber so that it displaces fluid from the chamber. The pump also includes an inlet channel and an outlet channel coupled to the chamber, the inlet channel being separated from the chamber by a first gap and the outlet channel separated from the chamber by a second gap. The gaps inhibit the gas from moving out of the chamber. Other microfluidic pumps and intraocular devices are also disclosed.
摘要翻译： 本文提供了用于植入患者眼睛附近的微流体泵。 泵包括第一基板部分和与第一基板部分相邻的第二基板部分和具有由第一和第二基板部分提供的底表面和顶表面的室。 在室内产生气体，使得其从腔室移出流体。 该泵还包括一个入口通道和一个与腔室相连接的出口通道，入口通道与腔室隔开第一间隙，出口通道与腔室隔开第二间隙。 间隙阻止气体移出腔室。 还公开了其它微流体泵和眼内装置。
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2.发明授权Systems and methods for an electrocapillary positive displacement pump for an intraocular implant 有权用于眼内植入物的电毛细管正位移泵的系统和方法公开(公告)号：US09504606B2
公开(公告)日：2016-11-29
申请号：US14181824
申请日：2014-02-17
申请人： NOVARTIS AG
CPC分类号： A61F9/00781 , A61F2250/0008 , A61F2250/0013 , A61M5/14224 , A61M5/14276 , A61M2205/0244 , A61M2210/0612
摘要： A microfluidic pump for implantation proximate an eye of a patient is disclosed herein. The microfluidic pump includes a first substrate with a microfluidic actuator that includes a first chamber and a second chamber coupled by a channel, an electrode in each of the chambers, and a slug positioned within the channel. The slug is displaceable by an electric potential. The microfluidic actuator of the microfluidic pump includes a reservoir aligned with the chamber, a membrane portion separating the reservoir and the chamber, and a second reservoir aligned with the second chamber. A second membrane portion separates the second reservoir and the second chamber. Each of the reservoirs has an inlet and an outlet; each of the inlets has a valve that prevents backflow. A second substrate of the microfluidic pump includes a flow path coupling the outlet of the first reservoir to the inlet of the second reservoir.
摘要翻译： 本文公开了一种用于植入患者眼睛附近的微流体泵。 微流体泵包括具有微流体致动器的第一衬底，其包括第一腔室和通过通道耦合的第二腔室，每个腔室中的电极和位于通道内的塞子。 芯块可以通过电位移位。 微流体泵的微流体致动器包括与腔室对准的储存器，分隔储存器和腔室的膜部分和与第二腔室对准的第二储存器。 第二膜部分分离第二储存器和第二室。 每个储存器具有入口和出口; 每个入口都具有防止回流的阀。 微流体泵的第二基板包括将第一储存器的出口连接到第二储存器的入口的流动路径。
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公开(公告)号：US20150297341A1
公开(公告)日：2015-10-22
申请号：US14257235
申请日：2014-04-21
申请人： Novartis AG
发明人： Zahra Noroozi , Ray Karam , Nicholas M. Gunn
CPC分类号： A61F9/00781 , F16K99/0015 , F16K99/0048 , F16K2099/0088
摘要： A valve system for an ocular implant device includes a boss structure. The boss structure includes an inlet for fluid inflow, and a number of outlets for fluid outflow. The valve system further includes a deformable membrane positioned over and spaced apart from the inlet, the membrane comprising a piezo-based material, an actuating element to apply pressure to the membrane to deform the membrane into a position that obstructs fluid flow from the inlet, and a control system to detect a position of the membrane based on measured electrical properties of the membrane.
摘要翻译： 用于眼部植入装置的瓣膜系统包括凸起结构。 凸台结构包括用于流体流入的入口和用于流体流出的多个出口。 所述阀系统还包括位于所述入口之上并与所述入口间隔开的可变形膜，所述膜包括基于压电材料的致动元件，以向膜施加压力以使膜变形成妨碍流体从入口流动的位置， 以及基于测量的膜的电性能来检测膜的位置的控制系统。
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公开(公告)号：US09456924B2
公开(公告)日：2016-10-04
申请号：US14257235
申请日：2014-04-21
申请人： Novartis AG
发明人： Zahra Noroozi , Ray Karam , Nicholas M. Gunn
CPC分类号： A61F9/00781 , F16K99/0015 , F16K99/0048 , F16K2099/0088
摘要： A valve system for an ocular implant device includes a boss structure. The boss structure includes an inlet for fluid inflow, and a number of outlets for fluid outflow. The valve system further includes a deformable membrane positioned over and spaced apart from the inlet, the membrane comprising a piezo-based material, an actuating element to apply pressure to the membrane to deform the membrane into a position that obstructs fluid flow from the inlet, and a control system to detect a position of the membrane based on measured electrical properties of the membrane.
摘要翻译： 用于眼部植入装置的瓣膜系统包括凸起结构。 凸台结构包括用于流体流入的入口和用于流体流出的多个出口。 所述阀系统还包括位于所述入口之上并与所述入口间隔开的可变形膜，所述膜包括基于压电材料的致动元件，以向膜施加压力以使膜变形成妨碍流体从入口流动的位置， 以及基于测量的膜的电性能来检测膜的位置的控制系统。
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5.发明申请SYSTEMS AND METHODS FOR A MEMBRANE-FREE ELECTROLYSIS PUMP FOR AN INTRAOCULAR IMPLANT 有权用于室内植入物的无膜电解泵的系统和方法公开(公告)号：US20150230984A1
公开(公告)日：2015-08-20
申请号：US14181851
申请日：2014-02-17
申请人： NOVARTIS AG
发明人： Nicholas M. Gunn
CPC分类号： A61F9/00781 , F04B19/006 , F04B43/043
摘要： A microfluidic pump for implantation proximate an eye of a patient is provided herein. The pump includes a first substrate portion and a second substrate portion adjacent the first and a chamber that has a bottom surface and a top surface provided by the first and second substrate portions. A gas is produced within the chamber so that it displaces fluid from the chamber. The pump also includes an inlet channel and an outlet channel coupled to the chamber, the inlet channel being separated from the chamber by a first gap and the outlet channel separated from the chamber by a second gap. The gaps inhibit the gas from moving out of the chamber. Other microfluidic pumps and intraocular devices are also disclosed.
摘要翻译： 本文提供了用于植入患者眼睛附近的微流体泵。 泵包括第一基板部分和与第一基板部分相邻的第二基板部分和具有由第一和第二基板部分提供的底表面和顶表面的室。 在室内产生气体，使得其从腔室移出流体。 该泵还包括一个入口通道和一个与腔室相连接的出口通道，入口通道与腔室隔开第一间隙，出口通道与腔室隔开第二间隙。 间隙阻止气体移出腔室。 还公开了其它微流体泵和眼内装置。
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