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公开(公告)号：US12097257B2
公开(公告)日：2024-09-24
申请号：US16977290
申请日：2019-03-04
申请人： NEW YORK UNIVERSITY
CPC分类号： A61K39/39 , A61K39/0011 , A61P35/00 , C07K14/4748 , C07K14/70521 , C07K14/70575 , C07K14/70578 , C12N7/00 , A61K2039/5256 , C07K2319/055 , C07K2319/30 , C12N2770/36132 , C12N2770/36143
摘要： Provided are polynucleotides and viral vectors, particularly, Alphavirus vectors such as Sindbis viral vectors, which encode an immune checkpoint protein, or a ligand binding portion of the checkpoint protein, or an immune checkpoint protein or ligand binding portion thereof fused to one or more immunoglobulin (Ig) domains, e.g., an Ig hinge region and an Ig heavy chain constant domain. Methods of treating a mammalian subject having a cancer or tumor are provided, in which the viral vectors, e.g., a Sindbis virus vector, encoding the immune checkpoint protein, a ligand binding portion thereof, or a checkpoint protein fusion protein as described, are administered to the subject, resulting in an anti-cancer or anti-tumor immune response, significant reduction in tumor growth in the treated subject and increased survivability.
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公开(公告)号：US20130137754A1
公开(公告)日：2013-05-30
申请号：US13644229
申请日：2012-10-03
申请人： New York University
发明人： Daniel Meruelo , Jen-Chieh Tseng
CPC分类号： C12N7/00 , A61K35/768 , A61K38/00 , A61K38/45 , A61K48/0058 , A61K51/0491 , C12N9/1211 , C12N9/78 , C12N15/86 , C12N2770/36132 , C12N2770/36143 , C12N2770/36145 , C12N2770/36171 , C12N2830/007 , C12Y207/01021 , G01N33/574 , G01N2800/52 , A61K2300/00
摘要： Disclosed herein are methods for treating a mammal harboring a solid tumor which expresses higher levels of High Affinity Laminin Receptors (LAMR) than normal cells of the same lineage comprising systematically administering to a mammal in need of such treatment a therapeutically effective amount of a Replication Competent (RC) Sindbis virus vector, wherein said vector encodes a suicide gene.
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3.发明申请Tumor Therapy With Antitumor Agents In Combination With Sindbis Virus-Based Vectors 审中-公开肿瘤治疗与抗肿瘤药物与基于辛比妥病毒的载体组合公开(公告)号：US20160008431A1
公开(公告)日：2016-01-14
申请号：US14798077
申请日：2015-07-13
申请人： New York University
发明人： Daniel Meruelo , Tomer Granot , Jen-Chieh Tseng
IPC分类号： A61K38/18 , A61K31/337
CPC分类号： A61K38/1866 , A61K31/337 , A61K33/24 , A61K35/768 , C12N15/86 , C12N2770/36132 , C12N2770/36143 , C12N2770/36145 , A61K2300/00 , A61K35/76
摘要： A method for treating malignant tumors with Sindbis viral based vectors in combination with antitumor agents and pharmaceutical formulations for use in such treatment.
摘要翻译： 用于治疗恶性肿瘤的方法，该方法用基于辛德毕斯病毒的载体与抗肿瘤剂和用于这种治疗的药物制剂联合治疗。
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4.发明申请公开(公告)号：US20210196839A1
公开(公告)日：2021-07-01
申请号：US17195236
申请日：2021-03-08
申请人： New York University
摘要： The subject application is directed to a method for treating a mammal harboring a tumor comprising identifying a tumor associated antigen (TAA) expressed by the tumor and parenterally administering to the mammal a therapeutically effective amount of a Sindbis viral vector carrying a gene encoding the TAA to the mammal sufficient to elicit an immune response directed against the tumor, and thereby treating the tumor.
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公开(公告)号：US20160115458A1
公开(公告)日：2016-04-28
申请号：US14882216
申请日：2015-10-13
申请人： New York University
发明人： Daniel Meruelo , Jen-Chieh Tseng
CPC分类号： C12N7/00 , A61K35/768 , A61K38/00 , A61K38/45 , A61K48/0058 , A61K51/0491 , C12N9/1211 , C12N9/78 , C12N15/86 , C12N2770/36132 , C12N2770/36143 , C12N2770/36145 , C12N2770/36171 , C12N2830/007 , C12Y207/01021 , G01N33/574 , G01N2800/52 , A61K2300/00
摘要： Disclosed herein are methods for treating a mammal harboring a solid tumor which expresses higher levels of High Affinity Laminin Receptors (LAMR) than normal cells of the same lineage comprising systematically administering to a mammal in need of such treatment a therapeutically effective amount of a Replication Competent (RC) Sindbis virus vector, wherein said vector encodes a suicide gene.
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6.发明申请公开(公告)号：US20180000912A1
公开(公告)日：2018-01-04
申请号：US15449641
申请日：2017-03-03
申请人： New York University
IPC分类号： A61K39/00 , C12N9/12 , C07K14/47 , C12N7/00 , C07K14/005
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/5256 , A61K2039/645 , C07K14/005 , C07K14/4747 , C07K14/4748 , C07K2319/40 , C07K2319/50 , C12N7/00 , C12N9/12 , C12N2770/36122 , C12N2770/36143 , C12N2840/20 , C12Y207/12002
摘要： Provided are polynucleotides and viral vectors, particularly, alphavirus vectors such as Sindbis viral vectors, which encode multiple, e.g., two or more, epitopes of at least one tumor associated antigen in which each epitope is separated by a processing or enzyme cleavage site. The multiple epitopes of the two or more tumor associated antigens encoded by the described polynucleotides and viral vectors may be the same or different. Methods of treating mammalian subjects having a cancer or tumor expressing the tumor associated antigen epitopes are provided, in which the viral vectors encoding the multiple epitopes, as well as other immunostimulatory or immunomodulatory components, generate an anti-cancer or anti-tumor immune response in which high levels of effector T cells increase the survivability of tumored mammalian subjects and result in epitope spreading, thus providing a further enhancement of the immune response.
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7.发明申请Method for inducing antitumor immunity using sindbis viral vectors and tumor associated antigens 有权使用辛德毕斯病毒载体和肿瘤相关抗原诱导抗肿瘤免疫的方法公开(公告)号：US20150071882A1
公开(公告)日：2015-03-12
申请号：US14478783
申请日：2014-09-05
申请人： New York University
CPC分类号： A61K48/0058 , A61K39/0011 , A61K2039/5256 , A61K2039/572 , C12N2770/36143
摘要： The subject application is directed to a method for treating a mammal harboring a tumor comprising identifying a tumor associated antigen (TAA) expressed by the tumor and parenterally administering to the mammal a therapeutically effective amount of a Sindbis viral vector carrying a gene encoding the TAA to the mammal sufficient to elicit an immune response directed against the tumor, and thereby treating the tumor.
摘要翻译： 本申请涉及用于治疗携带肿瘤的哺乳动物的方法，包括鉴定由肿瘤表达的肿瘤相关抗原（TAA），并且向哺乳动物肠胃外给予治疗有效量的携带编码TAA的基因的辛德毕斯病毒载体， 足以引发针对肿瘤的免疫应答，从而治疗肿瘤。
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公开(公告)号：US12116412B2
公开(公告)日：2024-10-15
申请号：US16489769
申请日：2018-03-05
申请人： NEW YORK UNIVERSITY
IPC分类号： C07K16/28 , A61K39/00 , A61P35/00 , C07K14/705 , C12N15/86
CPC分类号： C07K16/2818 , A61P35/00 , C07K14/705 , C12N15/86 , A61K39/00 , A61K2039/505 , C12N2770/36133 , C12N2770/36134 , C12N2770/36143 , C12N2770/36171
摘要： Provided are polynucleotides and viral vectors, e.g., alphavirus or Sindbis viral vectors, encoding multiple, e.g., two or more, epitopes of at least one tumor associated antigen, in which each epitope is separated by a processing or enzyme cleavage site. The encoded epitopes may be the same or different. Also provided are polynucleotides and viral vectors, particularly, alphavirus or Sindbis viral vectors, encoding an immune checkpoint protein, or a ligand binding portion thereof. The immune checkpoint protein or ligand binding portion thereof may be fused to immunoglobulin domains, e.g., an Ig hinge domain and an Ig heavy chain constant domain. Methods of treating subjects having a cancer or tumor, e.g., a TAA-expressing tumor, with the described viral vectors are provided. Treatment of subjects with the vectors, the checkpoint inhibitor molecules and/or other immunomodulatory components, generate an anti-cancer or anti-tumor immune response resulting in increased survivability of tumored subjects and epitope spreading.
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公开(公告)号：US20210000946A1
公开(公告)日：2021-01-07
申请号：US16977290
申请日：2019-03-04
申请人： NEW YORK UNIVERSITY
摘要： Provided are polynucleotides and viral vectors, particularly, Alphavirus vectors such as Sindbis viral vectors, which encode an immune checkpoint protein, or a ligand binding portion of the checkpoint protein, or an immune checkpoint protein or ligand binding portion thereof fused to one or more immunoglobulin (Ig) domains, e.g., an Ig hinge region and an Ig heavy chain constant domain. Methods of treating a mammalian subject having a cancer or tumor are provided, in which the viral vectors, e.g., a Sindbis virus vector, encoding the immune checkpoint protein, a ligand binding portion thereof, or a checkpoint protein fusion protein as described, are administered to the subject, resulting in an anti-cancer or anti-tumor immune response, significant reduction in tumor growth in the treated subject and increased survivability.
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公开(公告)号：US20200377598A1
公开(公告)日：2020-12-03
申请号：US16489769
申请日：2018-03-05
申请人： NEW YORK UNIVERSITY
IPC分类号： C07K16/28 , C07K14/705 , C12N15/86 , A61P35/00
摘要： Provided are polynucleotides and viral vectors, e.g., alphavins or Sindbis viral vectors, encoding multiple, e.g., two or more, epitopes of at least one tumor associated antigen, in which each epitope is separated by a processing or enzyme cleavage site. The encoded epitopes may be the same or different. Also provided are polynucleotides and viral vectors, particularly, alphavirus or Sindbis viral vectors, encoding an immune checkpoint protein, or a ligand binding portion thereof. The immune checkpoint protein or ligand binding portion thereof may be fused to immunoglobulin domains, e.g., an Ig hinge domain and an Ig heavy chain constant domain. Methods of treating subjects having a cancer or tumor, e.g., a TAA-expressing tumor, with the described viral vectors are provided. Treatment of subjects with the vectors, the checkpoint inhibitor molecules and/or other immunomodulatory components, generate an anti-cancer or anti-tumor immune response resulting in increased survivability of tumored subjects and epitope spreading.
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