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    COMPOSITIONS COMPRISING 3'-O-GLUCURONIDE EPICATECHIN AND METHODS OF MAKING AND USING SUCH COMPOSITIONS
    2.
    发明申请
    COMPOSITIONS COMPRISING 3'-O-GLUCURONIDE EPICATECHIN AND METHODS OF MAKING AND USING SUCH COMPOSITIONS 审中-公开

    公开(公告)号：US20200261485A1

    公开(公告)日：2020-08-20

    申请号：US16061527

    申请日：2016-12-15

    申请人： NESTEC S.A.

    发明人： Lucas Actis Goretta ,  Amaury Patin ,  Stephanie Michlig Gonzalez ,  Susana Camacho ,  Coline Legrand ,  Johannes Le Coutre ,  Euridice Castaneda Gutierrez ,  Irma Silva Zolezzi

    IPC分类号： A61K31/7048 ,  A61K9/00

    摘要： Compositions can comprise the flavanol metabolite 3′-O-glucuronide epicatechin (3GEC). In some embodiments, the amount of 3GEC is effective to increase energy expenditure, sympathetic nervous system activity, and/or fat oxidation. Such a composition can be used in a method to support weight management or promote weight loss, a method for preventing obesity or overweight, and a method for treating obesity or overweight. In some embodiments, the composition can improve insulin sensitivity, glucose tolerance, cognitive performance, cognition, mood and/or memory. In some embodiments, the composition can achieve a therapeutic effect selected from the group consisting of blood vessel dilation, reduced blood pressure, increased delivery of blood flow to tissues in the body, improvement of blood circulation, e.g. in brain, stimulation of protein synthesis, increased release of growth factors, enhanced immune function, and combinations thereof. In some embodiments, the composition can treat or prevent dysphagia, e.g., by provoking the swallowing reflex.

    Compositions comprising cinnamaldehyde and zinc and methods of using such compositions
    3.
    发明授权
    Compositions comprising cinnamaldehyde and zinc and methods of using such compositions 有权

    公开(公告)号：US11110120B2

    公开(公告)日：2021-09-07

    申请号：US15573562

    申请日：2016-05-24

    申请人： NESTEC S.A.

    发明人： Susana Camacho ,  Stephanie Michlig Gonzalez ,  Lucas Actis Goretta ,  Jenny Meylan Merlini ,  Johannes Le Coutre

    IPC分类号： A61K33/30 ,  A61K31/11 ,  A23L33/00 ,  A23L33/10 ,  A23L33/16 ,  A23L23/00 ,  A61P9/12 ,  A61P9/00 ,  A23C9/00

    摘要： Compositions comprise an amount of cinnamaldehyde that is orally tolerable, thus avoiding an unpleasant mouth feeling, and also tolerable in the gastrointestinal tract. The cinnamaldehyde is supplemented by zinc, and the combination can be effective to increase at least one of energy expenditure, sympathetic nervous system activity, or fat oxidation. The composition comprising the combination of cinnamaldehyde and zinc can be used in a method to support weight management or promote weight loss, a method for preventing obesity or overweight, and a method for treating obesity or overweight. The composition can improve one or more of insulin sensitivity, glucose tolerance, cognitive performance, cognition, mood or memory. The composition can achieve a therapeutic effect selected from the group consisting of blood vessel dilation, reduced blood pressure, increased delivery of blood flow to tissues in the body, stimulation of protein synthesis, increased release of growth factors, enhanced immune function, and combinations thereof.

    Methods and compositions for increasing energy expenditure using cinnamaldehyde
    4.
    发明授权
    Methods and compositions for increasing energy expenditure using cinnamaldehyde 有权

    公开(公告)号：US10159653B2

    公开(公告)日：2018-12-25

    申请号：US15103458

    申请日：2014-12-12

    申请人： NESTEC S.A.

    发明人： Stephanie Michlig Gonzalez ,  Johannes Le Coutre

    IPC分类号： A61K9/00 ,  A23L33/00 ,  A23L33/10 ,  A61K31/11 ,  A61K36/54 ,  A61K45/06

    摘要： Compositions comprise an amount of cinnamaldehyde that is orally tolerable, thus avoiding an unpleasant mouth feeling, and also tolerable in the gastrointestinal tract. The amount of cinnamaldehyde is effective to increase at least one of energy expenditure, sympathetic nervous system activity, or fat oxidation, relative to a composition lacking cinnamaldehyde but otherwise identical. The composition comprising cinnamaldehyde can be used in a method to support weight management or promote weight loss, a method for preventing obesity or overweight, and a method for treating obesity or overweight. In an embodiment, the composition comprising cinnamaldehyde is administered to a human. The composition comprising cinnamaldehyde may be a medicament, a food product or a supplement to a food product.

    Compositions comprising cinnamaldehyde and zinc and methods of using such compositions
    7.
    发明授权
    Compositions comprising cinnamaldehyde and zinc and methods of using such compositions 有权

    公开(公告)号：US10092028B2

    公开(公告)日：2018-10-09

    申请号：US15327108

    申请日：2015-06-08

    申请人： NESTEC S.A.

    发明人： Stephanie Michlig Gonzalez ,  Jenny Meylan Merlini ,  Susana Camacho ,  Johannes Le Coutre

    IPC分类号： A23L33/11 ,  A23L33/105 ,  A23L33/00 ,  A23L33/16 ,  A61K33/30 ,  A61K31/11

    摘要： Compositions comprise an amount of cinnamaldehyde that is orally tolerable, thus avoiding an unpleasant mouth feeling, and also tolerable in the gastrointestinal tract. The amount of cinnamaldehyde is supplemented by zinc, and the combination is effective to increase at least one of energy expenditure, sympathetic nervous system activity, or fat oxidation, relative to a composition lacking cinnamaldehyde and zinc but otherwise identical. The composition comprising the combination of cinnamaldehyde and zinc can be used in a method to support weight managementor promote weight loss, a method for preventing obesity or overweight, and a method for treating obesity or overweight. In an embodiment, the composition comprising cinnamaldehydeis administered to a human. The composition comprising cinnamaldehyde may be a medicament, a food product or a supplement. The composition can improve one or more of insulin sensitivity, glucose tolerance, cognitive performance, cognition, mood or memory.

    TREATMENT OR PREVENTION OF NON-INFLAMMATORY NEURONAL DAMAGE FROM BRAIN TRAUMA AND STROKES USING MENTHOL, LINALOOL AND/OR ICILIN
    8.
    发明申请
    TREATMENT OR PREVENTION OF NON-INFLAMMATORY NEURONAL DAMAGE FROM BRAIN TRAUMA AND STROKES USING MENTHOL, LINALOOL AND/OR ICILIN 审中-公开
    使用MENTHOL，LINALOOL和/或ICILIN治疗或预防来自脑TRAUMA和STROKA的非炎性神经损伤

    公开(公告)号：US20160166570A1

    公开(公告)日：2016-06-16

    申请号：US14892287

    申请日：2014-05-23

    申请人： NESTEC S.A.

    发明人： Susana Camacho ,  Stephanie Michlig Gonzalez ,  Johannes Le Coutre ,  Henry Markram ,  Maurizio Pezzoli

    IPC分类号： A61K31/513 ,  A61K31/045

    摘要： Compositions for prevention or treatment of non-inflammatory neuronal damage from brain trauma and strokes are provided, and the compositions contain a therapeutically effective amount of a compound selected from the group consisting of Menthol, Linalool, Icilin and combinations thereof. Methods for treatment or prevention of non-inflammatory neuronal damage from brain trauma and strokes are also provided, and the methods include administering such compositions.

    摘要翻译： 提供了用于预防或治疗脑创伤和中风的非炎症性神经元损伤的组合物，组合物含有治疗有效量的选自薄荷醇，芳樟醇，伊卡汀及其组合的化合物。 还提供了用于治疗或预防脑创伤和中风的非炎症性神经元损伤的方法，并且所述方法包括施用此类组合物。