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    Rapid fresh digital-pathology method
    2.
    发明公开
    Rapid fresh digital-pathology method 审中-公开

    公开(公告)号：US20240118202A1

    公开(公告)日：2024-04-11

    申请号：US17963247

    申请日：2022-10-11

    Applicant: National Taiwan University

    Inventor： Chi-Kuang Sun ,  Bhaskar Jyoti Borah ,  Yao-Chen Tseng

    IPC: G01N21/64 ,  G01N1/30

    CPC classification number: G01N21/6428 ,  G01N1/30 ,  G01N2001/302 ,  G01N2021/6439

    Abstract: A rapid fresh digital-pathology (RFP) method for assessing an excised unfixed biological specimen stained with hematoxylin (H) or eosin (E) or both hematoxylin and eosin (HE) staining dyes. The RFP method is assisted by a rapid tissue staining (RTS) procedure which is performed on the excised unfixed biological specimen, involving a short fixation; an H-staining; a rinsing; a bluing; an E-staining; a rinsing; and finally, a covering of a stained specimen with a coverslip. The RFP method is further assisted by a multimodal nonlinear optical laser-raster-scanning approach to provide with a nonlinear multi-harmonic generation and/or a nonlinear multi-photon excitation fluorescence signal(s) for multichannel digitization and real-time digital display of H- or E- or HE-specific histopathological features while providing a centimeter-scale imaging area, a submicron digital resolution, and a sustained effective data throughput of at least 500 Megabits per second (Mbps).

    Device for Improving Laser Wavelength Conversion Efficiency and High-power Multi-wavelength Fiber-format Femtosecond Laser System Using the Device
    3.
    发明申请
    Device for Improving Laser Wavelength Conversion Efficiency and High-power Multi-wavelength Fiber-format Femtosecond Laser System Using the Device 有权

    公开(公告)号：US20220190544A1

    公开(公告)日：2022-06-16

    申请号：US17118644

    申请日：2020-12-11

    Applicant: National Taiwan University

    Inventor： Chi-Kuang Sun ,  Yang-Ting Hsiao

    IPC: H01S3/067 ,  H01S3/00 ,  H01S3/16

    Abstract: This invention provides a device for improving laser wavelength conversion efficiency and a laser system configured to provide high-power multi-wavelength femtosecond laser pulses using the device. The device for improving laser wavelength conversion efficiency comprises a wavelength conversion member photonic crystal fiber (PCF), wherein the device for improving laser wavelength conversion efficiency improves wavelength conversion efficiency by shortening the length of the PCF. The device provided in this invention not only reduces the attenuation and dispersion caused by the optical fiber, but also improves the energy conversion efficiency within a specific wavelength range. The use of the technique not only increases the energy of light pulse, but also greatly reduces the amount of fiber used, and can maximize the energy of the desired wavelength according to experimental requirements when using laser input sources of different wavelengths.

    Protective assembly and imaging equipment set
    6.
    发明授权
    Protective assembly and imaging equipment set 有权

    公开(公告)号：US12228784B2

    公开(公告)日：2025-02-18

    申请号：US17563313

    申请日：2021-12-28

    Applicant: NATIONAL TAIWAN UNIVERSITY

    Inventor： Chi-Kuang Sun ,  Pei-Jhe Wu ,  Ying-Ting Huang ,  Hsiao-Chieh Tseng

    IPC: G02B7/02

    Abstract: A protective assembly and an imaging equipment set are provided. The protective assembly is used to accommodate an imaging lens, and includes a housing, a transparent partition, and an adhesive member. The housing includes a tube body segment and a bottom segment that is connected to the tube body segment. A curved portion is formed on a periphery of the bottom segment, and an accommodating space is defined by the housing. The imaging lens is movably disposed in the accommodating space. An inner side of the curved portion has an inclined surface that is configured to abut against a shell of the imaging lens. The transparent partition is disposed on the bottom segment of the housing. The adhesive member has an outer surface that is sticky and an inner surface that is fixed onto a bottom surface of the housing.

    Harmonics microscope for measuring glycated hemoglobin fraction of single red blood cell
    7.
    发明授权
    Harmonics microscope for measuring glycated hemoglobin fraction of single red blood cell 有权

    公开(公告)号：US12188862B2

    公开(公告)日：2025-01-07

    申请号：US18113704

    申请日：2023-02-24

    Applicant: National Taiwan University

    Inventor： Chi-Kuang Sun ,  Xu-hao Ye

    IPC: G01N21/31 ,  G01N33/49 ,  G02B21/00 ,  G02B27/10 ,  G02B27/14

    Abstract: A microscope is provided to measure HbA1c fraction. The microscope measures the HbA1c fraction of a single red blood cell (RBC) in a trace blood sample. The HbA1c fraction can be measured through a non-invasive way while the RBC flows in a human epidermal microvessel, too. The microscope comprises a laser device, an upright microscope, a light splitter, a light detector, and a mainframe. Unlike traditional methods, the HbA1c fraction can be measured in vitro or in vivo at the level of a single RBC. Accurate measurement is achieved. Misdiagnosis rate is reduced. The microscope provides HbA1c fractions from hundreds of RBCs, instead of averaging HbA1c fractions obtained from a large number of blood samples. Hence, the present invention is a method of detecting a HbA1c fraction of a single RBC, and is a microscope supporting blood-drawing measurement and non-invasive measurement simultaneously.

    Method of Data Analysis for Long-Term Blood Glucose Concentration Trend
    8.
    发明公开
    Method of Data Analysis for Long-Term Blood Glucose Concentration Trend 审中-公开

    公开(公告)号：US20240237925A1

    公开(公告)日：2024-07-18

    申请号：US18113692

    申请日：2023-02-24

    Applicant: National Taiwan University

    Inventor： Chi-Kuang Sun ,  Xu-hao Ye ,  Tzung-Dau Wang

    IPC: A61B5/145

    CPC classification number: A61B5/14532

    Abstract: A method of data analysis is provided. The method is used for finding a long-term trend of blood glucose concentration. The method builds a model for estimating long-term glycemic variability and long-term blood glucose trajectory. Based on single-erythrocyte-level glycated hemoglobin distribution, the glycemic variability is analyzed. A first analysis method is to give a number. The number shows the level of the historical glycemic variabilities. A second analysis method is to restore the blood glucose trajectory over the past 20 weeks. Based on the single-erythrocyte-level glycated hemoglobin distribution, the present invention easily assesses blood-glucose-related clinical information for about 150 days. Hence, an important complement is obtained for diabetes-related or glucose-monitoring-related clinical applications.

    Virtual spatial overlap modulation microscopy for resolution improvement
    10.
    发明授权
    Virtual spatial overlap modulation microscopy for resolution improvement 有权
    虚拟空间重叠调制显微镜用于分辨率改进

    公开(公告)号：US09384537B2

    公开(公告)日：2016-07-05

    申请号：US14474167

    申请日：2014-08-31

    Applicant: NATIONAL TAIWAN UNIVERSITY

    Inventor： Chi-Kuang Sun ,  Wei-Cheng Kuo

    IPC: G06K9/00 ,  G06T5/20 ,  G06T5/00

    CPC classification number: G06T5/20 ,  G06T5/001 ,  G06T5/008 ,  G06T2207/10056 ,  G06T2207/30088

    Abstract: A method and non-transitory computer readable medium for processing an oversampled image is disclosed. Filters are applied to an oversampled image to obtain a filtered image. The image filters are Gabor filter, cosine filter, laplacian of Gaussian filter, and radial filter. The filtered image can be turned into a displayed image that is displayed. The displayed image can be a 3D image. The displayed image can be refreshed at a rate of about one frame per second.

    Abstract translation: 公开了一种用于处理过采样图像的方法和非暂时计算机可读介质。 滤波器被应用于过采样图像以获得滤波图像。 图像滤波器是Gabor滤波器，余弦滤波器，高斯滤波器的拉普拉斯和径向滤波器。 过滤图像可以变成显示的显示图像。 显示的图像可以是3D图像。 显示的图像可以以大约每秒一帧的速率刷新。

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