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    NEW PROCESS
    1.
    发明公开
    NEW PROCESS 审中-公开

    公开(公告)号：US20240261228A1

    公开(公告)日：2024-08-08

    申请号：US18567466

    申请日：2022-06-10

    Applicant: NANEXA AB

    Inventor： Anders JOHANSSON ,  Mårten ROOTH ,  Erik LINDAHL

    IPC: A61K9/50 ,  A61K31/405 ,  A61K31/706

    CPC classification number: A61K9/5089 ,  A61K9/501 ,  A61K31/405 ,  A61K31/706

    Abstract: There is provided a process for the preparation of composition in the form of a plurality of particles having a weight-, number-, and/or volume-based mean diameter that is between amount 10 nm and about 700 μm, which particles comprise: (a) solid cores, preferably comprising a biologically active agent; and (b) two or more sequentially applied, discrete layers, each of which comprises at least one separately applied coating material, and which two or more layers together surround, enclose and/or encapsulate said cores, which process comprises the sequential steps of: (1) applying an initial layer of at least one coating material to said solid cores by way of a gas phase deposition technique; (2) subjecting the coated particles to agitation to deagglomerate particle aggregates formed during step (1) by way of a sieving step; (3) applying a further layer of at least one coating material to the deagglomerated particles; and (4) optionally repeating steps (2) and (3) one or more times to increase the total thickness of the at least one coating material that enclose(s) said solid core, wherein at least one of the sieving steps comprises a vibrational sieving technique, in which the vibrational sieving technique comprises supplying electrical power to a vibration motor coupled to a sieve. The gas phase deposition technique is preferably atomic layer deposition. When the cores comprise biologically active agent, the compositions may provide for the delayed or sustained release of said active agent without a burst effect.

    NEW PROCESS FOR THE MANUFACTURE OF PHARMACEUTICAL COMPOSITIONS
    2.
    发明申请
    NEW PROCESS FOR THE MANUFACTURE OF PHARMACEUTICAL COMPOSITIONS 有权

    公开(公告)号：US20230020272A1

    公开(公告)日：2023-01-19

    申请号：US17782734

    申请日：2020-12-04

    Applicant: NANEXA AB

    Inventor： Anders JOHANSSON ,  Marten ROOTH ,  Joel HELLRUP

    IPC: A61K9/50 ,  A61K31/706

    Abstract: There is provided a process for the preparation of composition in the form of a plurality of particles having a weight-, number-, and/or volume-based mean diameter that is between amount 10 nm and about 700 μm, which particles comprise: (a) solid cores, preferably comprising a biologically active agent; and (b) two or more sequentially applied, discrete layers, each of which comprises at least one separately applied coating material, and which two or more layers together surround, enclose and/or encapsulate said cores, which process comprises the sequential steps of: (1) applying an initial layer of at least one coating material to said solid cores by way of a gas phase deposition technique; (2) discharging the coated particles from the gas phase deposition reactor and subjecting the coated particles to agitation to disaggregate particle aggregates formed during step (1) by way of mechanical sieving technique; (3) reintroducing the disaggregated, coated particles from step (2) into the gas phase deposition reactor and applying a further layer of at least one coating material to the reintroduced particles; and (1) optionally repeating steps (2) and (3) one or more times to increase the total thickness of the at least one coating material that enclose(s) said solid core. The gas phase deposition technique is preferably atomic layer deposition. When the cores comprise biologically active agent, the compositions may provide for the delayed or sustained release of said active agent without a burst effect.

    INJECTABLE OIL-BASED PHARMACEUTICAL COMPOSITION
    5.
    发明公开
    INJECTABLE OIL-BASED PHARMACEUTICAL COMPOSITION 审中-公开

    公开(公告)号：US20230157968A1

    公开(公告)日：2023-05-25

    申请号：US17919415

    申请日：2021-04-16

    Applicant: NANEXA AB

    Inventor： Anders JOHANSSON ,  Mårten ROOTH ,  Joel HELLRUP

    IPC: A61K9/51 ,  A61K31/706 ,  A61K9/50

    CPC classification number: A61K9/5115 ,  A61K31/706 ,  A61K9/5192 ,  A61K9/501 ,  A61K9/5089 ,  A61K9/5123 ,  A61K9/0019

    Abstract: There is provided a pharmaceutical or veterinary formulation comprising: (a) a plurality of particles having a weight-, number-, or volume-based mean diameter that is between amount 10 nm and about 700 μm, which particles comprise solid cores coated with zinc oxide; suspended in (b) an oleaginous carrier system comprising a pharmaceutically-acceptable or veterinarily-acceptable oil, which zinc oxide coated particles comprise: (1) solid cores comprising a biologically-active agent; (2) one or more discrete layers surrounding said cores, said one or more layers each comprising at least one separate zinc oxide coating. Said zinc oxide coated particles are preferably synthesized via a gas phase coating technique, such as atomic layer deposition. When the cores comprise biologically-active agent, and the particles are suspended in an oleaginous carrier system, the formulation may provide for the delayed or sustained release of said active agent without a burst effect.

    APPARATUS
    6.
    发明申请
    APPARATUS 有权

    公开(公告)号：US20220307132A1

    公开(公告)日：2022-09-29

    申请号：US17545783

    申请日：2021-12-08

    Applicant: Nanexa AB

    Inventor： Anders JOHANSSON ,  Mårten ROOTH ,  Joel HELLRUP

    IPC: C23C16/455 ,  A61J3/00 ,  B01J2/00 ,  B01J13/04 ,  B05B7/00 ,  C23C16/54 ,  C23C16/44

    Abstract: A reactor for forming fully coated particles having a solid core, the reactor comprises a reactor vessel which is configured to receive particles, and a gas phase coating mechanism that is configured to selectively introduce pulses of gas phase materials that form a coating on the particles. The reactor also includes a sieve (16) that is located within the reactor vessel, and a forcing means that is configured to force the particles through the sieve (16) in use. The sieve is configured to deagglomerate any particle aggregates formed in the reactor vessel upon forcing of the particles by the forcing means through the sieve.

    NEW INJECTABLE COMBINATION FORMULATION
    7.
    发明申请
    NEW INJECTABLE COMBINATION FORMULATION 有权

    公开(公告)号：US20250041208A1

    公开(公告)日：2025-02-06

    申请号：US18717160

    申请日：2022-12-08

    Applicant: NANEXA AB

    Inventor： Anders JOHANSSON ,  Mårten ROOTH ,  Joel HELLRUP ,  David WESTBERG

    IPC: A61K9/00 ,  A61K9/50 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/5415 ,  A61K31/569 ,  A61K31/635 ,  A61K31/706

    Abstract: There is provided a pharmaceutical or veterinary formulation comprising: (a) a biologically-active agent in admixture with a pharmaceutically- or veterinarily-acceptable extended-release component; (b) an antiinflammatory agent; and (c) a pharmaceutically- or veterinarily-acceptable injectable carrier. An extended-release component may also be applied to the antiinflammatory agent. The formulation may provide for the delayed or sustained release of biologically active ingredient without producing an inflammatory response after injection, and s preferably provided in the form of: (1) a plurality of particles having a weight-, number-, or volume-based mean diameter that is between about 10 nm and about 700 μm, which particles comprise solid corms comprising a biologically-active agent coated with a coating comprising at least one coating material applied by way of a gas phase deposition technique; (2) which particles are suspended in a carrier system comprising a pharmaceutically-acceptable or veterinarily-acceptable vehicle; and (3) which formulation further includes an antiinflammatory agent, which is optionally in the form of particles that are coated with a coating comprising at least one coating material applied by way of a gas phase deposition technique. Said coated particles are preferably synthesized via atomic layer deposition.

    NEW COMPOSITION
    9.
    发明申请
    NEW COMPOSITION 有权

    公开(公告)号：US20230009472A1

    公开(公告)日：2023-01-12

    申请号：US17782564

    申请日：2019-12-06

    Applicant: Nanexa AB

    Inventor： Anders JOHANSSON ,  Mårten ROOTH ,  Joel HELLRUP

    IPC: A61K9/28 ,  A61K9/20 ,  A61K9/00 ,  A61K47/26 ,  A61K47/54 ,  A61K31/404

    Abstract: There is provided a composition comprising a plurality of particles of a weight-, number-, or volume-, based mean diameter that is between amount 10 nm and about 700 µm, which particles are made up of: (a) a solid core, which solid core preferably comprises a biologically active agent; (b) one or more discrete layers surrounding said core, said one or more layer s each comprising at least one separate coating material; and (c) a final overcoating layer of a coating material, which overcoating layer surrounds, encloses and/or encapsulates said core and said previously-applied layers of coating material, and which final layer is of a thickness that is less than said previously-applied layers. Said layers (b) and (c) are preferably applied by way of a gas phase coating technique, such as atomic layer deposition. When the cores comprise biologically active agent, the compositions may provide for the delayed or sustained release of said active agent without a burst effect.

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