公开(公告)号：US20160184271A1

公开(公告)日：2016-06-30

申请号：US14902951

申请日：2014-07-04

申请人： N.V. Nutricia

发明人： Sofia Lopes Da Silva

IPC分类号： A61K31/4172 ,  A61K31/405 ,  A23G4/14 ,  A61K31/198

CPC分类号： A61K31/4172 ,  A23G4/14 ,  A23L9/10 ,  A23L33/10 ,  A23L33/175 ,  A23L33/21 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/198 ,  A61K31/405 ,  A61K38/08 ,  A23V2200/3202 ,  A23V2200/322 ,  A23V2250/0624 ,  A23V2250/063 ,  A23V2250/0648 ,  A23V2250/548 ,  A23V2250/70 ,  A23V2250/065 ,  A23V2250/156 ,  A23V2250/161 ,  A23V2250/1846 ,  A23V2250/1882 ,  A23V2250/5034 ,  A23V2250/5062 ,  A23V2250/54 ,  A61K2300/00

摘要： The invention relates to the use of at least one amino acid, selected from the group of histidine, lysine, and threonine in the manufacture of a composition for use in the treatment of a pervasive development disorder, a neurogenetic syndrome associated with a pervasive development disorder or a symptom of a pervasive development disorder. The invention further relates to a food product comprising histidine, lysine, and/or threonine, to a supplement comprising histidine, lysine, and/or threonine and to a kit of parts comprising histidine, lysine, and/or threonine.

摘要翻译： 本发明涉及至少一种选自组氨酸，赖氨酸和苏氨酸的氨基酸在制备用于治疗普遍发育障碍的组合物中的应用，所述组合物是与普遍发育障碍相关的神经源性综合征 或普遍发育障碍的症状。 本发明还涉及包含组氨酸，赖氨酸和/或苏氨酸的食品，其包含组氨酸，赖氨酸和/或苏氨酸的补充剂和包含组氨酸，赖氨酸和/或苏氨酸的试剂盒。

公开(公告)号：US20160303159A1

公开(公告)日：2016-10-20

申请号：US15102136

申请日：2014-09-30

申请人： N.V. NUTRICIA

发明人： Sofia Lopes Da Silva

IPC分类号： A61K31/7072 ,  A61K31/14 ,  A61K31/683 ,  A61K31/519 ,  A61K31/375 ,  A61K33/04 ,  A61K31/714 ,  A61K31/4415 ,  A61K31/202 ,  A61K31/355

CPC分类号： A61K31/7072 ,  A23L33/10 ,  A23L33/12 ,  A23L33/15 ,  A23L33/175 ,  A23V2002/00 ,  A61K9/0053 ,  A61K31/14 ,  A61K31/202 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4415 ,  A61K31/519 ,  A61K31/593 ,  A61K31/683 ,  A61K31/7068 ,  A61K31/714 ,  A61K31/715 ,  A61K33/04 ,  A61K38/16 ,  A61K45/06 ,  A61K2300/00

摘要： The invention relates to a combination of a pyrimidine derivative and a fatty acid source for use in the treatment of constipation, in particular in the treatment of constipation in patients suffering from GI disorders, neurological disorders, or psychiatric disorders. Advantageously, the combination comprises one or more vitamins or fibres.

摘要翻译： 本发明涉及用于治疗便秘的嘧啶衍生物和脂肪酸源的组合，特别是在患有胃肠疾病，神经障碍或精神障碍的患者中治疗便秘。 有利地，组合包含一种或多种维生素或纤维。

公开(公告)号：US10821120B2

公开(公告)日：2020-11-03

申请号：US16308370

申请日：2017-06-09

申请人： N.V. NUTRICIA

发明人： Sofia Lopes Da Silva ,  Ladislaus Maria Broersen ,  Robert Johan Joseph Hageman ,  Jan Maarten Verkuijl

IPC分类号： A61K31/593 ,  A61K31/07 ,  A61K31/202 ,  A61K31/4415 ,  A61K31/714 ,  A61K31/519 ,  A61P29/00 ,  A61K31/14 ,  A61K31/355 ,  A61K31/375

摘要： The invention pertains to the use of therapeutically effective amounts of (i) vitamin A and/or functional equivalents, (ii) vitamin D and/or functional equivalents, and (iii) at least one omega-3 PUFA, preferably DHA and/or EPA, more preferably DHA and EPA, for the manufacture of a composition or medicament for treating, reducing and/or preventing neuroinflammation and/or symptoms associated with neuroinflammation in a subject in need thereof, as well as for reducing microglia activation, and/or for treating, reducing and/or preventing symptoms associated with excessive activation of microglia; and/or for reducing the secretion of inflammatory cytokines, preferably IL-6, and/or for treating, reducing and/or preventing symptoms associated with excessive secretion of inflammatory cytokines, in a subject in need thereof.