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公开(公告)号：US20180311242A1
公开(公告)日：2018-11-01
申请号：US15897549
申请日：2018-02-15
申请人： MYOKARDIA, Inc.
发明人： JOHAN OSLOB , Robert Anderson , Danielle Aubele , Marc Evanchik , Jonathan Charles Fox , Brian Kane , Puping Lu , Robert McDowell , Hector Rodriguez , Yonghong Song , Arvinder Sran
IPC分类号： A61K31/513 , A61K45/06 , C07D413/12 , C07D401/12 , C07D403/04 , C07D239/545 , C07D401/04 , C07D413/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D239/553
CPC分类号： A61K31/513 , A61K45/06 , C07D239/545 , C07D239/553 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12
摘要： Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.
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公开(公告)号：US09925177B2
公开(公告)日：2018-03-27
申请号：US15003662
申请日：2016-01-21
申请人： MyoKardia, Inc.
发明人： Johan Oslob , Danielle Aubele , Jae Kim , Robert McDowell , Yonghong Song , Arvinder Sran , Min Zhong
IPC分类号： C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D405/14 , C07D417/12 , C07D417/14 , C07D471/04 , A61K31/4545 , A61K31/501 , A61K31/454 , C07D401/02 , C07D407/02 , C07D407/14 , C07D409/02 , C07D411/14 , A61K31/496 , A61K31/506 , A61K45/06
CPC分类号： A61K31/4545 , A61K31/454 , A61K31/496 , A61K31/501 , A61K31/506 , A61K45/06 , C07D401/02 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/02 , C07D407/14 , C07D409/02 , C07D411/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.
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公开(公告)号：US20140378464A1
公开(公告)日：2014-12-25
申请号：US14309381
申请日：2014-06-19
申请人： MyoKardia, Inc.
发明人： Johan Oslob , Robert Anderson , Danielle Aubele , Marc Evanchik , Jonathan Charles Fox , Brian Kane , Puping Lu , Robert McDowell , Hector Rodriguez , Yonghong Song , Arvinder Sran
IPC分类号： C07D239/545 , A61K45/06 , C07D239/553 , C07D403/04 , C07D405/12 , C07D401/04 , C07D413/04 , C07D403/12 , A61K31/513 , C07D405/04
CPC分类号： A61K31/513 , A61K45/06 , C07D239/545 , C07D239/553 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12
摘要： Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.
摘要翻译： 提供了可用于治疗肥大性心肌病（HCM）和与左心室肥大或舒张功能障碍相关的病症的新的嘧啶二酮化合物及其药学上可接受的盐。 描述了化合物及其药学上可接受的盐的合成和表征，以及用于治疗HCM和其它心脏病形式的方法。
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公开(公告)号：US20200297726A1
公开(公告)日：2020-09-24
申请号：US16893500
申请日：2020-06-05
申请人： MYOKARDIA, INC.
发明人： Johan Oslob , Robert Anderson , Danielle Aubele , Marc Evanchik , Jonathan Charles Fox , Brian Kane , Puping Lu , Robert McDowell , Hector Rodriguez , Yonghong Song , Arvinder Sran
IPC分类号： A61K31/513 , C07D401/12 , A61K45/06 , C07D239/545 , C07D239/553 , C07D401/04 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12
摘要： Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.
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公开(公告)号：US09663516B2
公开(公告)日：2017-05-30
申请号：US14973132
申请日：2015-12-17
申请人： MyoKardia, Inc.
发明人： Johan Oslob , Danielle Aubele , Marc Evanchik , Jonathan Charles Fox , Mark Grillo , Brian Kane , Robert McDowell , Yonghong Song , Min Zhong
IPC分类号： C07D471/04 , C07D487/04 , A61K31/519 , A61K31/55 , A61K45/06
CPC分类号： C07D471/04 , A61K31/519 , A61K31/55 , A61K45/06 , C07D487/04
摘要： The present invention provides novel bicyclic pyrimidinedione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.
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公开(公告)号：US20160031862A1
公开(公告)日：2016-02-04
申请号：US14883179
申请日：2015-10-14
申请人： MyoKardia, Inc.
发明人： Johan Oslob , Robert Anderson , Danielle Aubele , Marc Evanchik , Jonathan Charles Fox , Brian Kane , Robert McDowell , Hector Rodriguez , Yonghong Song , Arvinder Sran , Pu-Ping Lu
IPC分类号： C07D405/12 , C07D405/04 , C07D401/04 , C07D239/545
CPC分类号： C07D405/12 , A61K31/513 , A61K45/06 , C07D239/545 , C07D401/04 , C07D403/04 , C07D405/04
摘要： The present invention provides novel cycloalkyl-substituted pyrimidine dione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.
摘要翻译： 本发明提供了可用于治疗肥厚性心肌病（HCM）和与左心室肥大或舒张功能障碍相关的病症的新型环烷基取代的嘧啶二酮化合物。 描述了化合物的合成和表征，以及用于治疗HCM和其它形式的心脏病的方法。
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公开(公告)号：US11123337B2
公开(公告)日：2021-09-21
申请号：US16934463
申请日：2020-07-21
申请人： MYOKARDIA, INC.
发明人： Johan Oslob , Danielle Aubele , Jae Kim , Robert McDowell , Yonghong Song , Arvinder Sran , Min Zhong
IPC分类号： C07D401/14 , C07D413/14 , C07D417/12 , C07D401/12 , C07D413/12 , C07D471/04 , C07D417/14 , A61K31/4545 , A61K31/454 , A61K31/496 , A61K31/506 , A61K45/06 , C07D405/14 , C07D411/14 , C07D409/02 , C07D407/14 , C07D407/02 , C07D401/02 , A61K31/501
摘要： The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.
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公开(公告)号：US10758525B2
公开(公告)日：2020-09-01
申请号：US16149912
申请日：2018-10-02
申请人： MyoKardia, Inc.
发明人： Johan Oslob , Danielle Aubele , Jae Kim , Robert McDowell , Yonghong Song , Arvinder Sran , Min Zhong
IPC分类号： A61P9/10 , A61K31/454 , A61K31/501 , C07D413/12 , C07D413/14 , C07D417/12 , A61K31/4545 , C07D401/14 , A61K31/496 , A61K31/506 , A61K45/06 , C07D401/12 , C07D405/14 , C07D471/04 , C07D411/14 , C07D409/02 , C07D407/14 , C07D407/02 , C07D401/02 , C07D417/14
摘要： The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.
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公开(公告)号：US20160176868A1
公开(公告)日：2016-06-23
申请号：US14973132
申请日：2015-12-17
申请人： MyoKardia, Inc.
发明人： Johan Oslob , Danielle Aubele , Marc Evanchik , Jonathan Charles Fox , Mark Grillo , Brian Kane , Robert McDowell , Yonghong Song , Min Zhong
IPC分类号： C07D471/04 , A61K45/06 , A61K31/55 , A61K31/519 , C07D487/04
CPC分类号： C07D471/04 , A61K31/519 , A61K31/55 , A61K45/06 , C07D487/04
摘要： The present invention provides novel bicyclic pyrimidinedione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.
摘要翻译： 本发明提供了可用于治疗肥厚性心肌病（HCM）和与左心室肥大或舒张功能障碍相关的病症的新型双环嘧啶二酮化合物。 描述了化合物的合成和表征，以及用于治疗HCM和其它形式的心脏病的方法。
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公开(公告)号：US20220117955A1
公开(公告)日：2022-04-21
申请号：US17407545
申请日：2021-08-20
申请人： MYOKARDIA, INC.
发明人： Johan Oslob , Danielle Aubele , Jae Kim , Robert McDowell , Yonghong Song , Arvinder Sran , Min Zhong
IPC分类号： A61K31/4545 , A61K31/454 , C07D401/14 , A61K31/496 , A61K31/506 , C07D413/14 , C07D417/12 , A61K45/06 , C07D401/12 , C07D405/14 , C07D413/12 , C07D471/04 , C07D411/14 , C07D409/02 , C07D407/14 , C07D407/02 , C07D401/02 , A61K31/501
摘要： The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.
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