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公开(公告)号：US20220117955A1
公开(公告)日：2022-04-21
申请号：US17407545
申请日：2021-08-20
申请人： MYOKARDIA, INC.
发明人： Johan Oslob , Danielle Aubele , Jae Kim , Robert McDowell , Yonghong Song , Arvinder Sran , Min Zhong
IPC分类号： A61K31/4545 , A61K31/454 , C07D401/14 , A61K31/496 , A61K31/506 , C07D413/14 , C07D417/12 , A61K45/06 , C07D401/12 , C07D405/14 , C07D413/12 , C07D471/04 , C07D411/14 , C07D409/02 , C07D407/14 , C07D407/02 , C07D401/02 , A61K31/501
摘要： The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.
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公开(公告)号：US20200113887A9
公开(公告)日：2020-04-16
申请号：US16149912
申请日：2018-10-02
申请人： MyoKardia, Inc.
发明人： Johan Oslob , Danielle Aubele , Jae Kim , Robert McDowell , Yonghong Song , Arvinder Sran , Min Zhong
IPC分类号： A61K31/4545 , A61K31/501 , C07D401/14 , A61K31/496 , A61K31/506 , C07D413/14 , C07D417/12 , A61K45/06 , C07D401/12 , C07D405/14 , C07D413/12 , C07D471/04 , C07D411/14 , C07D409/02 , C07D407/14 , C07D407/02 , C07D401/02 , A61K31/454
摘要： The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.
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公开(公告)号：US20160243100A1
公开(公告)日：2016-08-25
申请号：US15003662
申请日：2016-01-21
申请人： MyoKardia, Inc.
发明人： Johan Oslob , Danielle Aubele , Jae Kim , Robert McDowell , Yonghong Song , Arvinder Sran , Min Zhong
IPC分类号： A61K31/4545 , A61K45/06 , C07D401/12 , A61K31/501 , C07D413/12 , A61K31/506 , C07D413/14 , C07D471/04 , C07D417/12 , C07D405/14 , A61K31/496 , C07D401/14 , A61K31/454
CPC分类号： A61K31/4545 , A61K31/454 , A61K31/496 , A61K31/501 , A61K31/506 , A61K45/06 , C07D401/02 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/02 , C07D407/14 , C07D409/02 , C07D411/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.
摘要翻译： 本发明提供可用于治疗扩张型心肌病（DCM）的新型4-甲基砜取代的哌啶脲化合物和与左心室收缩功能障碍或/或右心室收缩功能障碍或收缩储备相关的病症。 描述了化合物的合成和表征，以及用于治疗DCM和其它形式的心脏病的方法。
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公开(公告)号：US09925177B2
公开(公告)日：2018-03-27
申请号：US15003662
申请日：2016-01-21
申请人： MyoKardia, Inc.
发明人： Johan Oslob , Danielle Aubele , Jae Kim , Robert McDowell , Yonghong Song , Arvinder Sran , Min Zhong
IPC分类号： C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D405/14 , C07D417/12 , C07D417/14 , C07D471/04 , A61K31/4545 , A61K31/501 , A61K31/454 , C07D401/02 , C07D407/02 , C07D407/14 , C07D409/02 , C07D411/14 , A61K31/496 , A61K31/506 , A61K45/06
CPC分类号： A61K31/4545 , A61K31/454 , A61K31/496 , A61K31/501 , A61K31/506 , A61K45/06 , C07D401/02 , C07D401/12 , C07D401/14 , C07D405/14 , C07D407/02 , C07D407/14 , C07D409/02 , C07D411/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
摘要： The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.
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公开(公告)号：US11123337B2
公开(公告)日：2021-09-21
申请号：US16934463
申请日：2020-07-21
申请人： MYOKARDIA, INC.
发明人： Johan Oslob , Danielle Aubele , Jae Kim , Robert McDowell , Yonghong Song , Arvinder Sran , Min Zhong
IPC分类号： C07D401/14 , C07D413/14 , C07D417/12 , C07D401/12 , C07D413/12 , C07D471/04 , C07D417/14 , A61K31/4545 , A61K31/454 , A61K31/496 , A61K31/506 , A61K45/06 , C07D405/14 , C07D411/14 , C07D409/02 , C07D407/14 , C07D407/02 , C07D401/02 , A61K31/501
摘要： The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.
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公开(公告)号：US10758525B2
公开(公告)日：2020-09-01
申请号：US16149912
申请日：2018-10-02
申请人： MyoKardia, Inc.
发明人： Johan Oslob , Danielle Aubele , Jae Kim , Robert McDowell , Yonghong Song , Arvinder Sran , Min Zhong
IPC分类号： A61P9/10 , A61K31/454 , A61K31/501 , C07D413/12 , C07D413/14 , C07D417/12 , A61K31/4545 , C07D401/14 , A61K31/496 , A61K31/506 , A61K45/06 , C07D401/12 , C07D405/14 , C07D471/04 , C07D411/14 , C07D409/02 , C07D407/14 , C07D407/02 , C07D401/02 , C07D417/14
摘要： The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.
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公开(公告)号：US20200345716A1
公开(公告)日：2020-11-05
申请号：US16934463
申请日：2020-07-21
申请人： MYOKARDIA, INC.
发明人： Johan Oslob , Danielle Aubele , Jae Kim , Robert McDowell , Yonghong Song , Arvinder Sran , Min Zhong
IPC分类号： A61K31/4545 , A61K31/454 , C07D401/14 , A61K31/496 , A61K31/506 , C07D413/14 , C07D417/12 , A61K45/06 , C07D401/12 , C07D405/14 , C07D413/12 , C07D471/04 , C07D411/14 , C07D409/02 , C07D407/14 , C07D407/02 , C07D401/02 , A61K31/501
摘要： The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.
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公开(公告)号：US20190269669A1
公开(公告)日：2019-09-05
申请号：US16149912
申请日：2018-10-02
申请人： MyoKardia, Inc.
发明人： Johan Oslob , Danielle Aubele , Jae Kim , Robert McDowell , Yonghong Song , Arvinder Sran , Min Zhong
IPC分类号： A61K31/4545 , A61K31/501 , C07D401/14 , A61K31/496 , A61K31/506 , C07D413/14 , C07D417/12 , A61K45/06 , C07D401/12 , C07D405/14 , C07D413/12 , C07D471/04 , C07D411/14 , C07D409/02 , C07D407/14 , C07D407/02 , C07D401/02 , A61K31/454
摘要： The present invention provides novel 4-methylsulphone-substituted piperidine urea compounds that are useful for the treatment of dilated cardiomyopathy (DCM) and conditions associated with left and/or right ventricular systolic dysfunction or systolic reserve. The synthesis and characterization of the compounds is described, as well as methods for treating DCM and other forms of heart disease.
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