公开(公告)号：US20240123035A1

公开(公告)日：2024-04-18

申请号：US18177455

申请日：2023-03-02

申请人： ModernaTX, Inc.

发明人： Antonin DE FOUGEROLLES ,  Kristy M. Wood ,  Sayda M. ELBASHIR ,  Noubar B. Afeyan ,  Pedro VALENCIA ,  Jason P. SCHRUM

IPC分类号： A61K38/19 ,  A61K9/00 ,  A61K9/127 ,  A61K9/14 ,  A61K9/16 ,  A61K31/7088 ,  A61K31/7105 ,  A61K38/48 ,  A61K48/00 ,  C07K2/00 ,  C07K14/535 ,  C12N15/00 ,  C12N15/117 ,  C12N15/88 ,  C12P21/00

CPC分类号： A61K38/193 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0048 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/14 ,  A61K9/16 ,  A61K9/1647 ,  A61K31/7088 ,  A61K31/7105 ,  A61K38/4833 ,  A61K48/00 ,  A61K48/0033 ,  A61K48/0041 ,  A61K48/005 ,  A61K48/0066 ,  C07K2/00 ,  C07K14/535 ,  C12N15/00 ,  C12N15/117 ,  C12N15/88 ,  C12P21/00

摘要： The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.

公开(公告)号：US20200164038A1

公开(公告)日：2020-05-28

申请号：US16525145

申请日：2019-07-29

申请人： ModernaTX, Inc.

发明人： Antonin DE FOUGEROLLES ,  Kristy M. WOOD ,  Sayda M. ELBASHIR ,  Noubar B. AFEYAN ,  Pedro VALENCIA ,  Jason P. SCHRUM

IPC分类号： A61K38/19 ,  C07K14/535 ,  A61K31/7105 ,  C12N15/117 ,  A61K48/00 ,  C12P21/00 ,  A61K31/7088 ,  C07K2/00 ,  C12N15/88 ,  A61K9/16 ,  A61K9/127 ,  A61K9/00 ,  C12N15/00 ,  A61K38/48 ,  A61K9/14

摘要： The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.

公开(公告)号：US20180125937A1

公开(公告)日：2018-05-10

申请号：US15621693

申请日：2017-06-13

申请人： ModernaTX, Inc.

发明人： Antonin DE FOUGEROLLES ,  Kristy M. WOOD ,  Sayda M. ELBASHIR ,  Noubar B. AFEYAN ,  Pedro VALENCIA ,  Jason P. SCHRUM

IPC分类号： A61K38/19 ,  C12N15/00 ,  C12P21/00 ,  A61K9/14 ,  A61K9/127 ,  A61K38/48 ,  A61K48/00 ,  C07K14/535 ,  A61K31/7105 ,  A61K9/16 ,  A61K9/00 ,  A61K31/7088 ,  C07K2/00 ,  C12N15/117 ,  C12N15/88

CPC分类号： A61K38/193 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0048 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/14 ,  A61K9/16 ,  A61K9/1647 ,  A61K31/7088 ,  A61K31/7105 ,  A61K38/4833 ,  A61K48/00 ,  A61K48/0033 ,  A61K48/0041 ,  A61K48/005 ,  A61K48/0066 ,  C07K2/00 ,  C07K14/535 ,  C12N15/00 ,  C12N15/117 ,  C12N15/88 ,  C12P21/00

摘要： The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and/or activity.