公开(公告)号：US20240358819A1

公开(公告)日：2024-10-31

申请号：US18577571

申请日：2022-07-08

Applicant: ModernaTX, Inc.

Inventor： Guillaume Stewart-Jones

IPC: A61K39/215 ,  A61K9/51 ,  A61K39/00 ,  A61P37/04

CPC classification number: A61K39/215 ,  A61K9/5123 ,  A61P37/04 ,  A61K2039/53 ,  A61K2039/6075

Abstract: The disclosure relates to pan human coronavirus ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：US20240207392A1

公开(公告)日：2024-06-27

申请号：US18286705

申请日：2022-04-13

Applicant: ModernaTX, Inc.

Inventor： Sumana Chandramouli ,  Brooke Bollman ,  Yen-Ting Lai ,  Guillaume Stewart-Jones ,  Andrea Carfi

IPC: A61K39/245 ,  A61K9/51 ,  A61K39/00 ,  A61P31/20 ,  A61P37/04

CPC classification number: A61K39/245 ,  A61K9/5123 ,  A61P31/20 ,  A61P37/04 ,  A61K2039/53 ,  A61K2039/6018

Abstract: The disclosure relates to Epstein-Barr virus ribonucleic acid vaccines as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：US20210228707A1

公开(公告)日：2021-07-29

申请号：US17000215

申请日：2020-08-21

Applicant: ModernaTX, Inc.

Inventor： Mihir Metkar ,  Vladimir Presnyak ,  Guillaume Stewart-Jones

IPC: A61K39/215 ,  C07H21/02 ,  A61K9/16

Abstract: The disclosure relates to coronavirus ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：US20240382581A1

公开(公告)日：2024-11-21

申请号：US18577563

申请日：2022-07-08

Applicant: ModernaTX, Inc.

Inventor： Guillaume Stewart-Jones

IPC: A61K39/215 ,  A61K9/127 ,  A61K9/51 ,  A61K39/00 ,  A61P31/14 ,  C12N7/00

Abstract: The disclosure relates to pan human coronavirus ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：US20240216500A1

公开(公告)日：2024-07-04

申请号：US18555087

申请日：2022-04-12

Applicant: ModernaTX, Inc.

Inventor： Raffael Nachbagauer ,  Carole Henry ,  Guillaume Stewart-Jones ,  Elisabeth Narayanan ,  Hamilton Bennett ,  Andrea Carfi

IPC: A61K39/145 ,  A61K39/00 ,  A61K39/155 ,  A61K39/215 ,  A61P31/16 ,  C12N7/00

CPC classification number: A61K39/145 ,  A61K39/155 ,  A61K39/215 ,  A61P31/16 ,  C12N7/00 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/55555 ,  A61K2039/70 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16234 ,  C12N2760/16251 ,  C12N2760/18334 ,  C12N2760/18351 ,  C12N2760/18534 ,  C12N2760/18551 ,  C12N2770/20034 ,  C12N2770/20051

Abstract: The disclosure provides combination mRNA vaccines for respiratory viruses, as well as methods of using the vaccines.

公开(公告)号：US20230355743A1

公开(公告)日：2023-11-09

申请号：US18028126

申请日：2021-09-24

Applicant: Guillaume STEWART-JONES, ,  ,Mihir METKAR ,  Vladimir PRESNYAK, ,  ModernaTX, Inc.

Inventor： Guillaume Stewart-Jones ,  Mihir Metkar ,  Vladimir Presnyak

IPC: A61K39/215 ,  C07K14/005 ,  A61K9/127 ,  A61P31/14

CPC classification number: A61K39/215 ,  C07K14/005 ,  A61K9/127 ,  A61P31/14 ,  A61K2039/53

Abstract: The disclosure provides coronavirus ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：US20240285754A1

公开(公告)日：2024-08-29

申请号：US18569768

申请日：2022-06-13

Applicant: ModernaTX, Inc.

Inventor： Guillaume Stewart-Jones

IPC: A61K39/215 ,  A61K9/127 ,  A61K9/51 ,  A61K39/00 ,  A61P31/14 ,  C07K14/005

CPC classification number: A61K39/215 ,  A61K9/1271 ,  A61K9/5123 ,  A61P31/14 ,  C07K14/005 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/575 ,  C12N2770/20022 ,  C12N2770/20034

Abstract: The disclosure provides mRNA vaccines which encode for coronavirus spike proteins exhibiting increased flexibility in the crown of the helix turn region. This increased flexibility is achieved by at least two glycine mutations within the crown of the helix turn region, located between the HR1 and CH regions.

公开(公告)号：US20240226277A1

公开(公告)日：2024-07-11

申请号：US18555130

申请日：2022-04-13

Applicant: ModernaTX, Inc.

Inventor： Raffael Nachbagauer ,  Carole Henry ,  Guillaume Stewart-Jones ,  Elsabeth Narayanan ,  Humilton Bennett ,  Andrea Carfi

IPC: A61K39/215 ,  A61K9/51 ,  A61K39/00 ,  A61K39/145 ,  A61K47/16 ,  A61P37/04

CPC classification number: A61K39/215 ,  A61K9/5123 ,  A61K39/145 ,  A61K47/16 ,  A61P37/04 ,  A61K2039/53 ,  A61K2039/70

Abstract: The disclosure provides combination miRNA vaccines for respiratory viruses, such as influenza and coronaviruses (e.g., SARS-CoV-2) as well as methods of using the vaccines.

公开(公告)号：US20240100151A1

公开(公告)日：2024-03-28

申请号：US18272512

申请日：2022-01-14

Applicant: ModernaTX, Inc.

Inventor： Andrea Carfi ,  Guillaume Stewart-Jones ,  Hamilton Bennett ,  Kai Wu ,  Darin Edwards ,  Gwo-Yu Chuang ,  David Reid

IPC: A61K39/215 ,  A61K9/127 ,  A61P31/14

CPC classification number: A61K39/215 ,  A61K9/1272 ,  A61P31/14 ,  A61K2039/53 ,  C12N2770/20034

Abstract: The disclosure provides coronavirus mRNA vaccines, including vaccines directed against one or more variant strains of SARS-CoV-2, as well as methods of using the vaccines.

公开(公告)号：US20230338506A1

公开(公告)日：2023-10-26

申请号：US17796401

申请日：2021-01-29

Applicant: ModernaTX, Inc.

Inventor： Christine Shaw ,  Guillaume Stewart-Jones ,  Elisabeth Narayanan ,  Vladimir Presnyak ,  Sayda Mahgoub Elbashir

IPC: A61K39/275 ,  A61K9/127 ,  C12N15/86 ,  A61K39/155 ,  A61P31/14 ,  C07K14/005

CPC classification number: A61K39/155 ,  A61K9/1271 ,  A61K39/275 ,  A61P31/14 ,  C07K14/005 ,  C12N15/86 ,  A61K2039/53

Abstract: The disclosure relates to respiratory virus ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines.