Invention Publication
- Patent Title: MRNA VACCINES ENCODING FLEXIBLE CORONAVIRUS SPIKE PROTEINS
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Application No.: US18569768Application Date: 2022-06-13
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Publication No.: US20240285754A1Publication Date: 2024-08-29
- Inventor: Guillaume Stewart-Jones
- Applicant: ModernaTX, Inc.
- Applicant Address: US MA Cambridge
- Assignee: ModernaTX, Inc.
- Current Assignee: ModernaTX, Inc.
- Current Assignee Address: US MA Cambridge
- International Application: PCT/US2022/033296 2022.06.13
- Date entered country: 2023-12-13
- Main IPC: A61K39/215
- IPC: A61K39/215 ; A61K9/127 ; A61K9/51 ; A61K39/00 ; A61P31/14 ; C07K14/005
Abstract:
The disclosure provides mRNA vaccines which encode for coronavirus spike proteins exhibiting increased flexibility in the crown of the helix turn region. This increased flexibility is achieved by at least two glycine mutations within the crown of the helix turn region, located between the HR1 and CH regions.
Information query
