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公开(公告)号：US20190248864A1
公开(公告)日：2019-08-15
申请号：US16398498
申请日：2019-04-30
Applicant: ModernaTX, Inc.
Inventor： Jeff Lynn ELLSWORTH , Joseph Beene BOLEN , Francine Marie GREGOIRE , Justin GUILD
IPC: C07K14/705
CPC classification number: C07K14/705 , A61K38/00
Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding low density lipoprotein receptor comprising at least one mutation (e.g., an LDLR signally enhancing mutation).
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