公开(公告)号：US20050206383A1

公开(公告)日：2005-09-22

申请号：US11059372

申请日：2005-02-17

Applicant: Minseok Park ,  Hiroshi Morita ,  Hideta Habara

Inventor： Minseok Park ,  Hiroshi Morita ,  Hideta Habara

IPC: G01R33/30 ,  G01R33/34 ,  G01V3/00

CPC classification number: G01R33/30

Abstract: There is providesd a nuclear magnetic resonance spectrometer having a high sensitiveness by simultaneously realizing a high uniformity of a static magnetic field and a high measuring sensitiveness. A sample tube used in the nuclear magnetic resonance spectrometer is constructed in a structure in which the shape of a sample placed in a measuring space can be changed. The change in shape of the sample can be achieved by controlling the pressure applied to the sample. There is at least one surface of contact between the sample placed in the measuring space and a gas existing around the sample, and the shape of such surface is maintained by the surface tension of the sample. In this case, a central portion of a magnet, into which the sample tube is inserted, filled with a sterilizing gas having a pressure higher than the atmospheric pressure, and the sample having a surface of contact with the gas is maintained in a sterile state. A measuring coil used in the nuclear magnetic resonance spectrometer is disposed on a rotatable curved surface symmetrical with respect to a rotational axis provided by a longitudinal center axis of the sample tube.

Abstract translation: 通过同时实现静磁场的高均匀性和高测量灵敏度，提供了具有高灵敏度的核磁共振光谱仪。 在核磁共振光谱仪中使用的样品管被构造成可以改变放置在测量空间中的样品的形状的结构。 可以通过控制施加到样品上的压力来实现样品的形状变化。 在放置在测量空间中的样品和存在于样品周围的气体之间存在至少一个接触表面，并且通过样品的表面张力保持这种表面的形状。 在这种情况下，将样品管插入其中的磁体的中心部填充有压力高于大气压的灭菌气体，并且与气体接触的表面的样品保持在无菌状态 。 在核磁共振光谱仪中使用的测量线圈设置在相对于由样品管的纵向中心轴线提供的旋转轴线对称的可旋转曲面上。

公开(公告)号：US07292035B2

公开(公告)日：2007-11-06

申请号：US11483777

申请日：2006-07-11

Applicant: Hideta Habara ,  Minseok Park

Inventor： Hideta Habara ,  Minseok Park

IPC: G01V3/00

CPC classification number: G01R33/34053 ,  G01R33/62

Abstract: An NMR/ESR antenna is inserted into a magnet device for generating a static magnetic field, and irradiates a sample with an electromagnetic wave to detect a signal generated from the sample. The NMR/ESR antenna comprises a sample tube, an NMR solenoid coil, an ESR microwave cavity, and a microwave guide. The solenoid coil has a central axis coaxial with a central axis of the ESR microwave cavity, and orthogonal to a direction of a main magnetic field generated by the magnetic device.

公开(公告)号：US07132830B2

公开(公告)日：2006-11-07

申请号：US11058356

申请日：2005-02-16

Applicant: Hideta Habara ,  Minseok Park

Inventor： Hideta Habara ,  Minseok Park

IPC: G01V3/00

CPC classification number: G01R33/3607

Abstract: An NMR apparatus has a circuit adapted to improve the degree freedom of design and generate an excitation radiofrequency wave pulse suited for a sample to be measured. The radiofrequency wave transmission circuit includes a local oscillator, an IQ modulator having two mixers and two arbitrary waveform generators connected to the IQ modulator. Fourier inverse transform is applied to data inputted to the arbitrary waveform generators.

Abstract translation: NMR装置具有适于提高设计自由度的电路，并产生适用于待测样品的激发射频波脉冲。 射频波发送电路包括本机振荡器，具有两个混频器的IQ调制器和连接到IQ调制器的两个任意波形发生器。 傅里叶反变换被应用于输入到任意波形发生器的数据。

公开(公告)号：US20060017441A1

公开(公告)日：2006-01-26

申请号：US11187856

申请日：2005-07-25

Applicant: Minseok Park ,  Hideta Habara

Inventor： Minseok Park ,  Hideta Habara

IPC: G01V3/00

CPC classification number: G01R33/389

Abstract: An NMR apparatus provided with a lock device having improved monotonicity without reducing a control range. In a lock device including a lock transmitter, a lock receiver, a lock detector, a lock corrector, a lock power supply and a lock coil, the lock detector performs complex detection of a detection signal and outputs to the lock corrector an absorption signal SA which is a real number component of the detection signal and a dispersion signal SD which is an imaginary number component of the detection signal; the lock corrector obtains a value SC by multiplying together SD/(SD2+SA2) and a value G, and the lock power supply performs adjustment so that a current flowing through the lock coil is proportional to SC. Different constants G are selectively used according to the value of SD/(SD2+SA2).

Abstract translation: 一种具有锁定装置的NMR装置，其具有改善的单调性，而不减少控制范围。 在包括锁定发送器，锁定接收器，锁定检测器，锁定校正器，锁定电源和锁定线圈的锁定装置中，锁定检测器执行检测信号的复杂检测，并向锁定校正器输出吸收信号SA 其是检测信号的实数分量和作为检测信号的虚数分量的色散信号SD; 锁定校正器通过将SD /（SD ^{2 + SA 2>）和值G相乘来获得值SC，并且锁定电源执行调整，使得电流流动 通过锁定线圈与SC成正比。 根据SD /（SD 2 + SA 2）的值选择使用不同的常数G。}

公开(公告)号：US20060158186A1

公开(公告)日：2006-07-20

申请号：US11330207

申请日：2006-01-12

Applicant: Minseok Park ,  Shuya Hagiwara ,  Hideta Habara

Inventor： Minseok Park ,  Shuya Hagiwara ,  Hideta Habara

IPC: G01V3/00

CPC classification number: G01R33/4633 ,  G01R33/4625

Abstract: In an NMR measurement method using an NMR apparatus which converts a received signal to digital data using an analog/digital converter and performs a spectral analysis, a folding and aliasing count is decided from a variation in a peak frequency and frequency discrimination is performed. More specifically, a Nyquist frequency is changed to cause a variation of the peak frequency. Since the Nyquist frequency is inversely proportional to an increment of an evolution time t1 which is a feature of multi-dimensional NMR, the Nyquist frequency can be changed by changing the increment of the evolution time. Furthermore, the Nyquist frequency is changed in such a way that a ratio between different Nyquist frequencies is not a ratio between natural numbers n1 and n2 which are greater than 0 and smaller than or equal to the maximum folding and aliasing count.

Abstract translation: 在使用使用模拟/数字转换器将接收信号转换为数字数据并执行频谱分析的NMR装置的NMR测量方法中，根据峰值频率的变化来确定折叠和混叠计数，并且执行频率鉴别。 更具体地，奈奎斯特频率被改变以引起峰值频率的变化。 由于奈奎斯特频率与作为多维NMR特征的演化时间t 1的增量成反比，可以通过改变演化时间的增量来改变奈奎斯特频率。 此外，奈奎斯特频率的改变使得不同奈奎斯特频率之间的比率不是大于0且小于或等于最大折叠和混叠计数的自然数n 1和n 2之间的比率。

公开(公告)号：US07372272B2

公开(公告)日：2008-05-13

申请号：US11206273

申请日：2005-08-18

Applicant: Hideta Habara ,  Minseok Park

Inventor： Hideta Habara ,  Minseok Park

IPC: G01V3/00

CPC classification number: G01R33/3607 ,  G01R33/3621

Abstract: An electromagnetic transceiver apparatus for a NMR apparatus has an intermediate frequency generator for preparing an intermediate wave, a transmission frequency converter for preparing, on the basis of an intermediate frequency of the intermediate wave, an electromagnetic wave to be radiated from a transmitter coil, a reception frequency converter for processing a signal received by the NMR probe, an analog-digital converter for converting an output of the reception frequency converter into a digital signal, an IQ detector for performing detection on the basis of an output of the analog-digital converter, a phase locked loop and a switch inserted between the analog-digital converter and the reception frequency converter to select either an input from the intermediate frequency generator or an input from the reception frequency converter.

Abstract translation: 用于NMR装置的电磁收发器装置具有用于制备中间波的中频发生器，用于根据中间波的中频来准备要从发射器线圈辐射的电磁波的发送频率转换器， 用于处理由NMR探头接收的信号的接收频率转换器，用于将接收频率转换器的输出转换为数字信号的模拟数字转换器，用于根据模拟数字转换器的输出进行检测的IQ检测器 插入在模拟数字转换器和接收频率转换器之间的锁相环和开关，以选择来自中频发生器的输入或来自接收变频器的输入。

公开(公告)号：US07167002B2

公开(公告)日：2007-01-23

申请号：US11187856

申请日：2005-07-25

Applicant: Minseok Park ,  Hideta Habara

Inventor： Minseok Park ,  Hideta Habara

IPC: G01V3/00

CPC classification number: G01R33/389

Abstract: An NMR apparatus provided with a lock device having improved monotonicity without reducing a control range. In a lock device including a lock transmitter, a lock receiver, a lock detector, a lock corrector, a lock power supply and a lock coil, the lock detector performs complex detection of a detection signal and outputs to the lock corrector an absorption signal SA which is a real number component of the detection signal and a dispersion signal SD which is an imaginary number component of the detection signal; the lock corrector obtains a value SC by multiplying together SD/(SD2+SA2) and a value G, and the lock power supply performs adjustment so that a current flowing through the lock coil is proportional to SC. Different constants G are selectively used according to the value of SD/(SD2+SA2).

Abstract translation: 一种具有锁定装置的NMR装置，其具有改善的单调性，而不减少控制范围。 在包括锁定发送器，锁定接收器，锁定检测器，锁定校正器，锁定电源和锁定线圈的锁定装置中，锁定检测器执行检测信号的复杂检测，并向锁定校正器输出吸收信号SA 其是检测信号的实数分量和作为检测信号的虚数分量的色散信号SD; 锁定校正器通过将SD /（SD ^{2 + SA 2>）和值G相乘来获得值SC，并且锁定电源执行调整，使得电流流动 通过锁定线圈与SC成正比。 根据SD /（SD 2 + SA 2）的值选择使用不同的常数G。}

公开(公告)号：US20070007961A1

公开(公告)日：2007-01-11

申请号：US11483777

申请日：2006-07-11

Applicant: Hideta Habara ,  Minseok Park

Inventor： Hideta Habara ,  Minseok Park

IPC: G01V3/00

CPC classification number: G01R33/34053 ,  G01R33/62

Abstract: An NMR/ESR antenna is inserted into a magnet device for generating a static magnetic field, and irradiates a sample with an electromagnetic wave to detect a signal generated from the sample. The NMR/ESR antenna comprises a sample tube, an NMR solenoid coil, an ESR microwave cavity, and a microwave guide. The solenoid coil has a central axis coaxial with a central axis of the ESR microwave cavity, and orthogonal to a direction of a main magnetic field generated by the magnetic device.

Abstract translation: 将NMR / ESR天线插入到用于产生静磁场的磁体装置中，并且用电磁波照射样品以检测从样品产生的信号。 NMR / ESR天线包括样品管，NMR电磁线圈，ESR微波腔和微波导。 螺线管线圈具有与ESR微波腔的中心轴同轴的中心轴线，并且与由磁性装置产生的主磁场的方向正交。

公开(公告)号：US07135865B2

公开(公告)日：2006-11-14

申请号：US11059372

申请日：2005-02-17

Applicant: Minseok Park ,  Hiroshi Morita ,  Hideta Habara

Inventor： Minseok Park ,  Hiroshi Morita ,  Hideta Habara

IPC: G01V3/00

CPC classification number: G01R33/30

Abstract: There is providesd a nuclear magnetic resonance spectrometer having a high sensitiveness by simultaneously realizing a high uniformity of a static magnetic field and a high measuring sensitiveness. A sample tube used in the nuclear magnetic resonance spectrometer is constructed in a structure in which the shape of a sample placed in a measuring space can be changed. The change in shape of the sample can be achieved by controlling the pressure applied to the sample. There is at least one surface of contact between the sample placed in the measuring space and a gas existing around the sample, and the shape of such surface is maintained by the surface tension of the sample. In this case, a central portion of a magnet, into which the sample tube is inserted, filled with a sterilizing gas having a pressure higher than the atmospheric pressure, and the sample having a surface of contact with the gas is maintained in a sterile state. A measuring coil used in the nuclear magnetic resonance spectrometer is disposed on a rotatable curved surface symmetrical with respect to a rotational axis provided by a longitudinal center axis of the sample tube.

Abstract translation: 通过同时实现静磁场的高均匀性和高测量灵敏度，提供了具有高灵敏度的核磁共振光谱仪。 在核磁共振光谱仪中使用的样品管被构造成可以改变放置在测量空间中的样品的形状的结构。 可以通过控制施加到样品上的压力来实现样品的形状变化。 在放置在测量空间中的样品和存在于样品周围的气体之间存在至少一个接触表面，并且通过样品的表面张力保持这种表面的形状。 在这种情况下，将样品管插入其中的磁体的中心部填充有压力高于大气压的灭菌气体，并且与气体接触的表面的样品保持在无菌状态 。 在核磁共振光谱仪中使用的测量线圈设置在相对于由样品管的纵向中心轴线提供的旋转轴线对称的可旋转曲面上。

公开(公告)号：US07282912B2

公开(公告)日：2007-10-16

申请号：US11330207

申请日：2006-01-12

Applicant: Minseok Park ,  Shuya Hagiwara ,  Hideta Habara

Inventor： Minseok Park ,  Shuya Hagiwara ,  Hideta Habara

IPC: G01V3/00

CPC classification number: G01R33/4633 ,  G01R33/4625

Abstract: In an NMR measurement method using an NMR apparatus which converts a received signal to digital data using an analog/digital converter and performs a spectral analysis, a folding and aliasing count is decided from a variation in a peak frequency and frequency discrimination is performed. More specifically, a Nyquist frequency is changed to cause a variation of the peak frequency. Since the Nyquist frequency is inversely proportional to an increment of an evolution time t1 which is a feature of multi-dimensional NMR, the Nyquist frequency can be changed by changing the increment of the evolution time. Furthermore, the Nyquist frequency is changed in such a way that a ratio between different Nyquist frequencies is not a ratio between natural numbers n1 and n2 which are greater than 0 and smaller than or equal to the maximum folding and aliasing count.

Abstract translation: 在使用使用模拟/数字转换器将接收信号转换为数字数据并执行频谱分析的NMR装置的NMR测量方法中，根据峰值频率的变化来确定折叠和混叠计数，并且执行频率鉴别。 更具体地，奈奎斯特频率被改变以引起峰值频率的变化。 由于奈奎斯特频率与作为多维NMR特征的演化时间t 1的增量成反比，可以通过改变演化时间的增量来改变奈奎斯特频率。 此外，奈奎斯特频率的改变使得不同奈奎斯特频率之间的比率不是大于0且小于或等于最大折叠和混叠计数的自然数n 1和n 2之间的比率。