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1.发明授权Treating breast cancer and inhibiting cancer-associated bone loss with anti-IL-20 antibody 有权用抗IL-20抗体治疗乳腺癌并抑制癌症相关的骨丢失公开(公告)号：US08535674B2
公开(公告)日：2013-09-17
申请号：US12815855
申请日：2010-06-15
Applicant: Ming-Shi Chang
Inventor： Ming-Shi Chang
IPC: A61K39/395
CPC classification number: C07K16/244 , A61K2039/505 , C07K2317/73
Abstract: Use of an anti-IL-20 antibody, either alone or in combination with an anti-RANKL antibody, for treating breast cancer and inhibiting cancer-associated bone loss.
Abstract translation: 单独使用或与抗RANKL抗体组合的抗IL-20抗体用于治疗乳腺癌和抑制癌症相关的骨丢失。
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2.发明授权Methods for treating rheumatoid arthritis and osteoporosis with anti-IL-20 antibodies 有权用抗IL-20抗体治疗类风湿性关节炎和骨质疏松症的方法公开(公告)号：US08454956B2
公开(公告)日：2013-06-04
申请号：US12869224
申请日：2010-08-26
Applicant: Ming-Shi Chang
Inventor： Ming-Shi Chang
IPC: A61K39/395
CPC classification number: A61K39/3955 , A61K2039/505 , C07K16/244 , C07K16/2887 , C07K2317/70 , C07K2317/76
Abstract: The invention features methods and compositions for preventing or treating rheumatoid arthritis and osteoporosis by administering an antagonist of IL-20. The IL-20 antagonist may be an anti-IL-20 antibody, such as mAB 7E, that is capable of binding human IL-20 and blocking IL-20 interaction with its receptors.
Abstract translation: 本发明的特征在于通过施用IL-20拮抗剂预防或治疗类风湿性关节炎和骨质疏松症的方法和组合物。 IL-20拮抗剂可以是能够结合人IL-20并阻断IL-20与其受体的相互作用的抗IL-20抗体，例如mAB 7E。
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公开(公告)号：US08377441B2
公开(公告)日：2013-02-19
申请号：US12849377
申请日：2010-08-03
Applicant: Ming-Shi Chang
Inventor： Ming-Shi Chang
IPC: A61K39/395
CPC classification number: C07K16/2803 , A61K2039/505
Abstract: Use of an anti-IL-19 antibody for treating breast cancer, either alone or in combination with an anti-IL-20 and/or anti-IL-20R1 antibody.
Abstract translation: 单独或与抗IL-20和/或抗IL-20R1抗体组合使用抗IL-19抗体治疗乳腺癌。
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公开(公告)号：US20100298229A1
公开(公告)日：2010-11-25
申请号：US12637722
申请日：2009-12-14
Applicant: William J. BOYLE , David L. Lacey , Frank J. Calzone , Ming-Shi Chang
Inventor： William J. BOYLE , David L. Lacey , Frank J. Calzone , Ming-Shi Chang
CPC classification number: C07K16/2878 , C07K14/70578 , C07K2319/30 , G01N2333/7151
Abstract: The present invention discloses a novel secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind OPG, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
Abstract translation: 本发明公开了一种称为骨保护素的新型分泌多肽，其是肿瘤坏死因子受体超家族的成员，并且参与骨代谢的调节。 还公开了编码骨保护素，多肽，重组载体和表达宿主细胞，结合OPG的抗体和药物组合物的核酸。 多肽用于治疗以增加再吸收为特征的骨疾病，例如骨质疏松症。
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公开(公告)号：US20100086549A1
公开(公告)日：2010-04-08
申请号：US12246691
申请日：2008-10-07
Applicant: Ming-Shi Chang
Inventor： Ming-Shi Chang
IPC: A61K39/395
CPC classification number: C07K16/244 , A61K2039/505 , C07K2317/56 , Y10S530/809
Abstract: Treatment of stroke with an antibody specific to IL-20, e.g., monoclonal antibody 7E.
Abstract translation: 用IL-20特异性抗体治疗中风，例如单克隆抗体7E。
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Patent Agency Ranking
公开(公告)号：US20050221331A1
公开(公告)日：2005-10-06
申请号：US10762159
申请日：2004-01-20
Applicant: William Boyle , David Lacey , Frank Calzone , Ming-Shi Chang
Inventor： William Boyle , David Lacey , Frank Calzone , Ming-Shi Chang
IPC: A61K38/00 , A61K48/00 , C07K14/705 , C12Q1/68 , C07H21/04 , C07K14/475 , C12N15/09
CPC classification number: C07K14/70578 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
Abstract: The present invention discloses a novel secreted polypeptide, termed osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind OPG, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
Abstract translation: 本发明公开了一种称为骨保护素的新型分泌多肽，其是肿瘤坏死因子受体超家族的成员，并且参与骨代谢的调节。 还公开了编码骨保护素，多肽，重组载体和表达宿主细胞，结合OPG的抗体和药物组合物的核酸。 多肽用于治疗以增加再吸收为特征的骨疾病，例如骨质疏松症。
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公开(公告)号：US20120034224A1
公开(公告)日：2012-02-09
申请号：US12849336
申请日：2010-08-03
Applicant: Ming-Shi Chang
Inventor： Ming-Shi Chang
IPC: A61K39/395 , A61P19/02
CPC classification number: C07K16/244 , A61K2039/505
Abstract: Treating rheumatoid arthritis with an anti-IL-19 antibody, optionally in combination with another anti-RA agent.
Abstract translation: 用抗IL-19抗体治疗类风湿性关节炎，任选地与另一种抗RA剂组合。
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公开(公告)号：US20120034208A1
公开(公告)日：2012-02-09
申请号：US12849377
申请日：2010-08-03
Applicant: Ming-Shi Chang
Inventor： Ming-Shi Chang
IPC: A61K39/395 , A61P35/00
CPC classification number: C07K16/2803 , A61K2039/505
Abstract: Use of an anti-IL-19 antibody for treating breast cancer, either alone or in combination with an anti-IL-20 and/or anti-IL-20R1 antibody.
Abstract translation: 单独或与抗IL-20和/或抗IL-20R1抗体组合使用抗IL-19抗体治疗乳腺癌。
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公开(公告)号：US20110305699A1
公开(公告)日：2011-12-15
申请号：US12815927
申请日：2010-06-15
Applicant: Ming-Shi Chang
Inventor： Ming-Shi Chang
IPC: A61K39/395 , A61P35/00
CPC classification number: C07K16/244 , A61K2039/505 , C07K2317/73
Abstract: Treating oral cancer with an anti-IL-20 antibody.
Abstract translation: 用抗IL-20抗体治疗口腔癌。
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10.发明申请Treating Breast Cancer and Inhibiting Cancer-Associated Bone loss with Anti-IL-20 Antibody 有权用抗IL-20抗体治疗乳腺癌和抑制癌症相关骨丢失公开(公告)号：US20110305698A1
公开(公告)日：2011-12-15
申请号：US12815855
申请日：2010-06-15
Applicant: Ming-Shi Chang
Inventor： Ming-Shi Chang
IPC: A61K39/395 , A61P19/00 , A61P35/00
CPC classification number: C07K16/244 , A61K2039/505 , C07K2317/73
Abstract: Use of an anti-IL-20 antibody, either alone or in combination with an anti-RANKL antibody, for treating breast cancer and inhibiting cancer-associated bone loss.
Abstract translation: 单独使用或与抗RANKL抗体组合的抗IL-20抗体用于治疗乳腺癌和抑制癌症相关的骨丢失。
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