知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

3 条记录 (耗时 0.045 秒)

    Use of a fermented soy extract as a prebiotic composition
    1.
    发明授权
    Use of a fermented soy extract as a prebiotic composition 有权
    使用发酵大豆提取物作为益生元组合物

    公开(公告)号：US09259450B2

    公开(公告)日：2016-02-16

    申请号：US13186956

    申请日：2011-07-20

    申请人： Ming-Hong Chuang ,  Cheng Der Tony Yu ,  Kung-Ming Lu

    发明人： Ming-Hong Chuang ,  Cheng Der Tony Yu ,  Kung-Ming Lu

    IPC分类号： A61K35/00 ,  A61K36/48 ,  A61K31/43

    CPC分类号： A61K36/48 ,  A61K31/43 ,  A61K2035/115 ,  A61K2300/00

    摘要： The present invention relates to use of a fermented soy extract as a prebiotic composition to protect beneficial bacteria in the gastrointestinal tract of an animal. Particularly, the fermented soy extract of the invention exhibits the prebiotic activity even under an antibiotic treatment. Also disclosed is combined use of an antibiotic and the fermented soy extract of the invention, which has advantages over administration of the antibiotic alone, such as decreasing the effective dose of the antibiotic and/or reducing side effects resulting from the antibiotic treatment.

    摘要翻译： 本发明涉及发酵大豆提取物作为益生元组合物来保护动物胃肠道中的有益细菌的用途。 特别地，本发明的发酵大豆提取物即使在抗生素治疗下也显示益生元活性。 还公开了本发明的抗生素和发酵大豆提取物的组合使用，其具有优于单独使用抗生素的优点，例如降低抗生素的有效剂量和/或减少由抗生素治疗引起的副作用。

    Methods and compositions for enhancing skin permeation of drugs using permeation enhancers, when drugs and/or permeation enhancers are unstable in combination during long-term storage
    3.
    发明授权
    Methods and compositions for enhancing skin permeation of drugs using permeation enhancers, when drugs and/or permeation enhancers are unstable in combination during long-term storage 失效
    当药物和/或渗透增强剂在长期储存期间组合不稳定时，使用渗透促进剂增强药物皮肤渗透的方法和组合物

    公开(公告)号：US6019988A

    公开(公告)日：2000-02-01

    申请号：US751293

    申请日：1996-11-18

    申请人： Prakash Parab ,  Cheng Der Tony Yu ,  Bhiku Patel

    发明人： Prakash Parab ,  Cheng Der Tony Yu ,  Bhiku Patel

    IPC分类号： A61K9/06 ,  A61K9/70

    CPC分类号： A61K9/06 ,  A61K9/7023

    摘要： The invention provides methods and means for enhancing the epidermal, transdermal and dermal permeation of a topically applied pharmacologically active agent (e.g., a drug or medicament) which has a low rate of skin penetration in the absence of a permeation enhancer and which is unstable and degrades during long-term storage with particular permeation enhancers. Also provided by the invention are methods and means to increase the skin penetration of a pharmacologically active agent which has a normally low rate of skin permeation and causes the instability and degradation of a permeation enhancer with which it is combined over a long period of time. Provided by the invention are at least one first composition containing a drug, a pharmaceutically acceptable salt, chemical derivative or formulation thereof, in a dermatologically acceptable vehicle, and at least one second composition containing a permeation enhancer in an acceptable vehicle. The compositions are physically separated until application to a body or skin surface and are topically applied, either at the same time, or sequentially within a short time of each other, and mixed or blended to form a final active composition, preferably on the skin. In addition, a premixture of the compositions can be made and applied to the skin in accordance with the invention. The invention allows a therapeutically effective amount of drug to be delivered into the skin and systemic circulation and provides significant enhancement of a drug's otherwise low level of skin permeation by the action of permeation enhancer in the active composition at the point of use.

    摘要翻译： 本发明提供用于增强局部施用的药理活性剂（例如药物或药物）的表皮，透皮和皮肤渗透的方法和手段，其在不存在渗透促进剂的情况下具有低的皮肤渗透率，并且其不稳定和 在长期储存期间，使用特定的渗透促进剂会降解。 本发明还提供增加药物活性剂的皮肤渗透性的方法和手段，所述药理活性剂通常具有通常低的皮肤渗透速率并导致长时间混合的渗透促进剂的不稳定性和降解性。 通过本发明提供了至少一种含有药物，药学上可接受的盐，化学衍生物或其制剂，在皮肤病学可接受的载体中的第一组合物和至少一种含有可接受载体中的渗透促进剂的第二组合物。 物理分离组合物，直到施用于身体或皮肤表面，并且在相互之间或相互之间相互短时间内局部施用，并混合或混合以形成最终活性组合物，优选在皮肤上。 此外，根据本发明，可以制备并施用组合物的预混物到皮肤。 本发明允许治疗有效量的药物被递送到皮肤和全身循环中，并且在使用时通过渗透促进剂在活性组合物中的作用提供药物的另外低水平的皮肤渗透的显着增强。