公开(公告)号：US20210220404A1

公开(公告)日：2021-07-22

申请号：US17104983

申请日：2020-11-25

申请人： Michael R. Greene ,  Novartis AG

发明人： Aida Abujoub ,  John Blankenship ,  Attilio Bondanza ,  Jennifer Brogdon ,  Dexiu Bu ,  Serena De Vita ,  Glenn Dranoff ,  Boris Engels ,  Tony Fleming ,  Brian Walter Granda ,  Michael R. Greene ,  Carla Patricia Guimaraes ,  Anniesha Hack ,  Brian Holmberg ,  Connie Hong ,  Lu Huang ,  Olja Kodrasi ,  Joni Waiee Lam ,  Hyungwook Lim ,  Elizabeth Dorothy Pratico ,  Andrew Price ,  Akash Sohoni ,  Andrew Marc Stein ,  Louise Treanor ,  Chonghui Zhang ,  Xu Zhu

IPC分类号： A61K35/17 ,  C07K16/28 ,  A61P35/00 ,  A61K45/06 ,  A61K39/395 ,  C07K14/705 ,  A61K38/17 ,  C12N5/0783 ,  C07K14/725

摘要： The invention provides immune effector cells (for example, T cells, NK cells) that express a chimeric antigen receptor (CAR), and compositions and methods thereof.

公开(公告)号：US20210214459A1

公开(公告)日：2021-07-15

申请号：US17059056

申请日：2019-05-30

申请人： Novartis AG ,  SURFACE ONCOLOGY, INC.

发明人： Ansgar Brock ,  Viviana Cremasco ,  Catherine Anne Sabatos-Peyton ,  Glenn Dranoff ,  Kulandayan Kasi Subramanian ,  Marie-Louise Fjaellskog ,  John Delmas Venable, III ,  Bianka Prinz ,  Jerry M. Thomas ,  Andrew Lake ,  Scott Chappel ,  Pamela Holland ,  Michael Warren ,  Alison Paterson ,  Rachel W. O'Connor ,  Michael Gladstone ,  Jonathan Hill ,  Christine Miller

IPC分类号： C07K16/28 ,  G01N33/573

摘要： Antibody molecules that bind to CD73 are disclosed. The anti-CD73 antibody molecules can be used to treat, prevent and/or diagnose cancer.

公开(公告)号：US20200281973A1

公开(公告)日：2020-09-10

申请号：US16082035

申请日：2017-03-03

申请人： Novartis AG ,  The Trustees of the University of Pennsylvania

发明人： Glenn Dranoff

IPC分类号： A61K35/17 ,  C07K16/30 ,  C07K16/28 ,  C07K14/725 ,  C07K14/705 ,  C12N15/86 ,  A61P35/02

摘要： The invention provides compositions and methods for treating diseases associated with expression of a tumor antigen as described herein by administration of a cell comprising a chimeric antigen receptor that binds a B-Cell antigen and a chimeric antigen receptor which binds a tumor antigen.

公开(公告)号：US20160108123A1

公开(公告)日：2016-04-21

申请号：US14881888

申请日：2015-10-13

申请人： Novartis AG ,  DANA-FARBER CANCER INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Gordon James Freeman ,  Arlene Helen Sharpe ,  Gerhard Johann Frey ,  Hwai Wen Chang ,  Jennifer Marie Mataraza ,  Glenn Dranoff

IPC分类号： C07K16/28 ,  A61N5/10 ,  A61K45/06 ,  G01N33/574 ,  A61K39/395 ,  C07K16/30

CPC分类号： C07K16/2827 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61N5/10 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K16/3053 ,  C07K16/3069 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57492 ,  G01N2333/70532

摘要： Antibody molecules that specifically bind to PD-L1 are disclosed. Combination therapies comprising the anti-PD-L1 antibody molecules are also disclosed. The anti-PD-L1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.

摘要翻译： 公开了特异性结合PD-L1的抗体分子。 还公开了包含抗-PD-L1抗体分子的组合疗法。 抗PD-L1抗体分子可用于治疗，预防和/或诊断癌性或感染性疾病和病症。

公开(公告)号：US20230013364A1

公开(公告)日：2023-01-19

申请号：US17549586

申请日：2021-12-13

申请人： Novartis AG ,  DANA-FARBER CANCER INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Glenn Dranoff ,  Gordon James Freeman ,  Arlene Helen Sharpe ,  Walter A. Blattler ,  Jennifer Marie Mataraza ,  Catherine Anne Sabatos-Peyton ,  Hwai Wen Chang ,  Gerhard Johann Frey

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  A61K39/395

摘要： Combination therapies comprising antibody molecules that specifically bind to PD-1 are disclosed. The combination therapies can be used to treat or prevent cancerous or infectious conditions and disorders.

公开(公告)号：US20220133889A1

公开(公告)日：2022-05-05

申请号：US17478370

申请日：2021-09-17

申请人： Novartis AG ,  DANA-FARBER CANCER INSTITUTE, INC. ,  The Children's Medical Center Corporation

发明人： Glenn Dranoff ,  Catherine Anne Sabatos-Peyton ,  Barbara Brannetti ,  Alan S. Harris ,  Thomas Huber ,  Thomas Pietzonka ,  Jennifer Marie Mataraza ,  Walter A. Blattler ,  Daniel J. Hicklin ,  Maximiliano Vasquez ,  Rosemarie H. DeKruyff ,  Dale T. Umetsu ,  Gordon James Freeman ,  Tiancen Hu ,  John A. Taraszka ,  Fangmin Xu

IPC分类号： A61K39/395 ,  A61K39/00 ,  C07K16/28 ,  A61P35/00 ,  A61K45/06

摘要： Combination therapies comprising antibody molecules that specifically bind to TIM-3 are disclosed. The combination therapies can be used to treat or prevent cancerous or infectious conditions and disorders.

公开(公告)号：US20200172628A1

公开(公告)日：2020-06-04

申请号：US16625293

申请日：2018-06-21

申请人： Viviana Cremasco ,  Novartis AG

发明人： Viviana Cremasco ,  Catherine Anne Sabatos-Peyton ,  Glenn Dranoff

IPC分类号： C07K16/28

摘要： Anti-CD73 antibody molecules and combination therapies thereof are disclosed. The antibody molecules and combination therapies disclosed herein can be used to treat or prevent cancer.

公开(公告)号：US20180222982A1

公开(公告)日：2018-08-09

申请号：US15747873

申请日：2016-07-28

申请人： Glenn Dranoff ,  Gordon James Freeman ,  Arlene Helen Sharpe ,  Walter A. Blattler ,  Jennifer Marie Mataraza ,  Catherine Anne Sabatos-Peyton ,  Hwai Wen Chang ,  Gerhard Johann Frey ,  Novartis AG ,  DANA-FARBER CANCER INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Glenn Dranoff ,  Gordon James Freeman ,  Arlene Helen Sharpe ,  Walter A. Blattler ,  Jennifer Marie Mataraza ,  Catherine Anne Sabatos-Peyton ,  Hwai Wen Chang ,  Gerhard Johann Frey

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61K39/395

CPC分类号： C07K16/2818 ,  A61K39/00 ,  A61K39/39541 ,  A61K2039/505 ,  A61P35/00 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92

摘要： Combination therapies comprising antibody molecules that specifically bind to PD-1 disclosed. The combination therapies can be used to treat or prevent cancerous or infectious conditions and disorders.

公开(公告)号：US20180186882A1

公开(公告)日：2018-07-05

申请号：US15900153

申请日：2018-02-20

申请人： Novartis AG ,  DANA-FARBER CANCER INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Gordon James Freeman ,  Arlene Helen Sharpe ,  Gerhard Johann Frey ,  Hwai Wen Chang ,  Jennifer Marie Mataraza ,  Glenn Dranoff

IPC分类号： C07K16/28 ,  G01N33/574 ,  A61N5/10 ,  C07K16/30 ,  A61K45/06 ,  A61K39/00

CPC分类号： C07K16/2827 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61N5/10 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K16/3053 ,  C07K16/3069 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57492 ,  G01N2333/70532

摘要： Antibody molecules that specifically bind to PD-L1 are disclosed. Combination therapies comprising the anti-PD-L1 antibody molecules are also disclosed. The anti-PD-L1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.

公开(公告)号：US09988452B2

公开(公告)日：2018-06-05

申请号：US14881888

申请日：2015-10-13

申请人： Novartis AG ,  DANA-FARBER CANCER INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： Gordon James Freeman ,  Arlene Helen Sharpe ,  Gerhard Johann Frey ,  Hwai Wen Chang ,  Jennifer Marie Mataraza ,  Glenn Dranoff

IPC分类号： C07K16/28 ,  C07K16/30 ,  C12N15/11 ,  C12N5/10 ,  A61K45/06 ,  A61N5/10 ,  G01N33/574 ,  A61K39/00

CPC分类号： C07K16/2827 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61N5/10 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K16/3053 ,  C07K16/3069 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/57492 ,  G01N2333/70532

摘要： Antibody molecules that specifically bind to PD-L1 are disclosed. Combination therapies comprising the anti-PD-L1 antibody molecules are also disclosed. The anti-PD-L1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.