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公开(公告)号：US20240102044A1
公开(公告)日：2024-03-28
申请号：US18190954
申请日：2023-03-27
发明人： Marc van Dijk , Volker Seibert , Cornelia Anne Mundt , Arthur Andrew Hurwitz , Mark Adrian Exley , Benjamin Jacob Wolf , Daniel Leventhal , Sébastien Lalevée , Reed Masakayan
IPC分类号： C12N15/85 , A61K47/64 , A61K47/65 , C07K14/085 , C07K14/725 , C07K14/74 , C07K16/18
CPC分类号： C12N15/85 , A61K47/6425 , A61K47/65 , C07K14/085 , C07K14/7051 , C07K14/70539 , C07K16/18 , C07K2317/32 , C07K2317/34 , C07K2317/565 , C07K2319/02
摘要： Provided are TCRs (e.g., TCRs that bind to NY-ESO-1), cells and pharmaceutical compositions comprising these TCRs, nucleic acids encoding these TCRs, expression vectors and host cells for making these TCRs, and methods of treating a subject using these TCRs.
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公开(公告)号：US11613764B2
公开(公告)日：2023-03-28
申请号：US16512031
申请日：2019-07-15
发明人： Marc van Dijk , Volker Seibert , Cornelia Anne Mundt , Arthur Andrew Hurwitz , Mark Adrian Exley , Benjamin Jacob Wolf , Daniel Leventhal , Sébastien Lalevée , Reed Masakayan
IPC分类号： C12N15/85 , A61K47/64 , C07K14/725 , C07K16/18 , A61K47/65 , C07K14/085 , C07K14/74
摘要： Provided are TCRs (e.g., TCRs that bind to NY-ESO-1), cells and pharmaceutical compositions comprising these TCRs, nucleic acids encoding these TCRs, expression vectors and host cells for making these TCRs, and methods of treating a subject using these TCRs.
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公开(公告)号：US11898165B2
公开(公告)日：2024-02-13
申请号：US15759007
申请日：2016-09-09
IPC分类号： C07K14/725 , C07K14/705 , C12N15/86 , G01N33/50 , C12N5/0783 , C12N15/10
CPC分类号： C12N5/0646 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70578 , C12N15/1037 , C12N15/86 , G01N33/5005 , C07K2319/00 , C12N2740/10043
摘要： Provided herein are engineered host cells suitable for expression of functional T cell receptors (TCR) and methods of using these cells to identify TCRs that specifically bind to a desired peptide-major histocompatibility complex (MHC) complex.
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